Trineuron Pymepharco medicine treats vitamin B1, B6, B12 (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Vitamin B1, Vitamin B6, Vitamin B12

Ingredient

Composition information	Content
Vitamin B1	50mg
Vitamin B6	250mg
Vitamin B12	250mcg

Uses

Indications

Trineuron drugs are indicated for treatment of diseases due to vitamin B1, B6, B12: neuritis, multiple neuritis, disease Anemia .

Pharmacology

Fursultiamin: is the derivative of Thiamin, with the advantages more than conventional thiamin hydrochrate:

with high affinity for tissue.

Fast conversion into the activity form of Thiamin is cocarboxylase.

Pharmacological, Fursultiamin also has an analgesic effect, power with other painkillers, anti -intestinal impact and bladder disorders due to neurological causes.

pyridoxin HCI (vitamin B6): plays a very important role in the metabolism of protein and lipid. Increase the activity of damaged nerve cells. Pyridoxin directly affects the absorption of amino acids from the small intestine. The evidence is increasing that this vitamin is closely related to the metabolism of the nervous system.

Cyanocobalamin (Vitamin B12): Prevent and treat anemia, maintain normal functions of epithelial cells, nervous systems and the creation of red blood cells. Cyanocobalamin is necessary in the process of synthesizing pyridoxin nucleoprotein and muscle fibers, regenerating cells, normal development of the body is large, maintaining hematoma function, ... Due to the conversion of methyl (transmethylation) related to the transformation of Homocystein into methionin acts as a liver and fat protection agent.

pharmacokinetic

furriamin:

Good absorption through the gastrointestinal tract, high concentration in blood and prolonged effects, not decomposed by aneurinase, very low toxicity and unwanted effect.

pyridoxin HCI (vitamin B6):

Quick absorption through the gastrointestinal tract after drinking. In patients after gastric cutting surgery, weaker absorption. Palming mainly in the liver, a little in the muscle, brain. The total reserve in the body is about 16 - 27 mg. In red blood cells, pyridoxin is transformed into pyridoxal phosphate activity. In the liver, pyridoxine is phosphoryl turned into pyridoxal phosphate and then converted into pyridoxal and pyridoxamin. Pyridoxal phosphate is fully connected to plasma proteins, pyridoxin is not associated with plasma proteins. Pyridoxin is stored mainly in the liver and part of the muscle and brain. The half -life is from 15-20 days. In the liver, pyridoxine is oxidized to 4-pyridoxic acid and is eliminated in the urine. Pyridoxin also passes the placenta and breast milk. If used exceeds daily needs, excreted drugs are not metabolized in the urine.

cyanocobalamin (vitamin B12):

Absorb in the stomach, Cyanocobalamin attacks internal factors present in the digestive tract, then cyanocobalamin is absorbed into the body. Linking with proteins, especially transcobalamin, this combination leads to the rapid absorption of cyanocobalamin into the tissue. Distribution into the liver, bone marrow, placenta, breast milk. Metabolized into coenzyme in the liver is also stored in tissue. Cyanocobalamin reserves in the liver, excreted through bile, the absorption is excreted through the urine in the first 8 hours.

Before taking Trineuron Pymepharco medicine treats vitamin B1, B6, B12 (5 blisters x 10 tablets)

How to use

Take medicine with water.

Dosage

take 1-3 tablets/day or as directed by the doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?
What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using trineuron medicine , you may experience unwanted effects (ADR).

Use vitamin B6 dose of 200 mg/day and long (over 2 months) can cause severe peripheral neuropathy, progressing from unstable gait and numbness to numbness and clumsy hands. This condition can recover when stopping the drug, although there is still more or less sequelae.

rarely

Nausea and vomiting.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trineuron contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug.

Cases of malignant tumors.

Precautions when using

Children should be used under adult supervision.

The ability to drive and operate machinery

does not affect.

Pregnancy

Used only when prescribed by a doctor.

Breastfeeding period

Drug interaction

pyridoxin reduces the effect of levodopa in the treatment of Parkinson's disease; This does not happen to the preparation is a mixture of Levodopa - Carbidopa or Levodopa - Benserazid.

Dosage of pyridoxin 200 mg/day can cause a decrease in 40-50% of the concentration of phenytoin and phenobarbiton in the blood in some patients.

pyridoxin can lighten depression in women who take birth control pills. Oral contraceptives can increase Pyridoxin demand.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

Other drugs

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