Triplixamamamamamamamamamamamamamamamamomioser/5mg Servier Treatment of hypertension (30 tablets)

Dosage form Box of 30 tablets
Specifications Amlodipine, indapamide, perindopril

Ingredient

Composition informationContent
Amlodipine10mg
Indapamide2.5mg
Perindopril5mg

Uses

indications

Triplixam is indicated in the following cases: Alternative treatment in the treatment of hypertension for patients who have been controlled blood pressure when combining Perindopril/Indapamid and Amlodipine with the same content.

Pharmacological

is a combination of three -component hypotension with complementary mechanisms to help control blood pressure in hypertension patients. Perindopril arginin is an angiotensin -shifting enzyme inhibitor, indapamid is a chlorosulphamoyl and amlodipine diuretic that is a calcium ion inhibitor of the dihydropyrine group.

Triplixam's pharmacological characteristics are a combination of pharmacological characteristics of each separate ingredient. In addition, the combination of perindopril/indapamid creates an effective plus effect of hypotension from these two components.

Dynamic pharmacokinetics

oral at the same time Perindopril indapamid and amlodipine do not change the pharmacokinetic properties compared to drinking each component separately.

perindopril

absorption

Perindopril is quickly absorbed and the peak concentration is reached within 1 hour. To ensure bioavailability, drink Perindopril Arginin once a day in the morning before meals.

Distribution

Perindoprilat's distribution volume is free of about 0.2 l/kg. Perindoprilat's bond ratio with plasma protein is 20%.

Metabolism

Perindopril is a medication. 27% of Perindopril oral dose absorbed into the general circulation in the form of metabolites with Perindoprilat activity.

Elimination

Perindoprilat is eliminated through the urine and the semi -discharged time of the free form is about 17 hours, reaching a stable state within 4 days.

indapamid

absorption

Indapamid is absorbed quickly and completely through the digestive tract. The peak concentration in plasma is achieved in people about an hour after taking the drug.

Distribution

The ratio of cohesion with plasma protein is 79%.

Metabolism and elimination

Sell waste time ranges from 14 and 24 hours (an average of 18 hours). Elimination mainly through urine (70 % of oral dose) and feces (22 %).

amlodipin

absorption

After drinking at the level of treatment, Amlodipine is well absorbed with the peak concentration of 6 - 12 hours.

Distribution

The distribution volume is about 21 l/kg, 97.5% amlodipine in the blood linked to plasma proteins.

Metabolism

amlodipine is strongly metabolized in the liver.

Elimination

Selling excretion time from plasma is about 35 - 50 hours and therefore can be used once a day.

Before taking Triplixamamamamamamamamamamamamamamamamomioser/5mg Servier Treatment of hypertension (30 tablets)

How to use

Triplixams are used for orally, it is best to drink in the morning and before meals.

Fixed dose combination is not suitable for the beginning therapy.

Dosage

One tablet daily. When the dose adjustment is needed, should be adjusted for each ingredient.

Special human objects

Patients with renal failure

In patients with severe renal impairment, medium renal failure, contraindicated with triplixamamamamamamamamamamamamamamamamamamplaretons.

Patients with liver failure

In patients with severe liver failure, contraindicated with Triplixam. In patients with mild to moderate liver failure, Triplixam should be used with carefulness due to the recommended dose of Arnlodipin in these patients that have not been established.

Older patients

can treat triplixams for older adults depending on the kidney function.

Children

The safety and effectiveness of Triplixams in children and minors have not been published, there is no data.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Triplixam, you may experience unwanted effects (ADR).

Common, ADR> 1/100

  • Neurological: dizziness, headache, dizziness, paresthesia, taste rebellion.
  • eyes: visual impairment.

    • Tinnitus.

  • Blood vessels: blushing, hypotension.
  • Respiratory: cough, shortness of breath.
    • digestive: abdominal pain, diarrhea, constipation, nausea, vomiting.
  • Other disorders: itching, rash, muscle pain, weakness, ...

    • Uncommon, 1/1000

  • Infection: rhinitis.
  • Blood and lymphatic system: Eosin hypernagus.
    • immunity: hypersensitivity. Metabolism: Hypoglycemia, hyperkalemia, hypoglyc sodium.
  • Mental: Change mood, sleep disorders.
    • nerve: drowsiness, decrease feeling.
  • Heart: Brush the chest drum, heart fast.
    • Other disorders: dry mouth, urticaria, angioedema, increased sweating, muscle pain, joint pain, chest pain, discomfort, ...

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Triplixam drugs contraindicated in the following cases:

  • Patients with dialysis.
  • Patients with loss of heart failure without being treated.

    • Severe renal failure (Creatinine clearance

    Hypersensitivity to the active ingredient, or any sulfonamid derivatives, sensitive to Dihydropyridine derivatives, with any angiotensin -shaped enzyme inhibitors or any ingredients of the drug.

    History of angioedema (edema) related to the previous Angiotensin enzyme inhibitors.

    Evaluation or idiopathic or idiopathic.

  • phase 2 and 3 of pregnancy.

    • breastfeeding.

  • Hepatic enhancement.
  • severe liver failure.
  • Hypotension.
  • Hypotension.
  • SHARE (including cardiac shock).
  • Left ventricular artery congestion (aortic stenosis).

    • Hemodynamic failure is not calm after acute myocardial infarction.

  • Simultaneous treatment of triplixams with Aliskiren -containing drugs in diabetics or kidney failure (glomerular filtration

    Be cautious when using

    all warnings related to each component, listed below, should be applied in the coordination of the fixed dose of Triplixam.

    Neutral leukemia/grain leukemia/thrombocytopenia/anemia

    Neutral leukemia/grain leukemia, thrombocytopenia and anemia have been reported in patients using angiotensin -shifting enzyme inhibitors.

    Hypersensitivity/eagles

    Facility on the face, limb, lips, tongue, subjects and/or larynx have been reported in patients treated with enzyme inhibitors in the form of angiotensin, including perindopril.

    Anaphylactic reactions in the sensitive process

    Angiotensin -shifting enzyme inhibitors should be used with caution in allergens who have been treated for sensitivity, and avoid used in patients who are using therapeutic immunity.

    Anaphylactic reactions in the process of filtering low density lipoprotein (LDL)

    It is possible to avoid these anaphylactic reactions by temporarily stopping the enzyme inhibitor in the form of angiotensin before each filter.

    Patient with blood viaer

    In these patients, it is advisable to consider the use of other blood -absorbing membranes or use other anti -hypertension drugs.

    The ability to drive and operate machinery

    There has been no research on the influence of Triplixam on the ability to drive and operate machinery. Perindopril and Indopamid do not affect the ability to drive and operate machinery, but separate reactions related to hypotension may occur in some patients. Amlodipine may have a slight or moderate effect on the ability to drive and operate machinery.

    If patients have symptoms of dizziness, headache, fatigue or nausea, the ability to react may be impaired. As a result, the ability to drive and operate machinery may be impaired. Precautions especially when starting.

    Pregnancy

    Triplixam is not recommended in the first pregnancy use. Contraindications during pregnancy second and third.

    breastfeeding period

    Triplixam is contraindicated during breastfeeding. Need to decide to stop breastfeeding or stop treatment with triplixam.

    Drug interaction

    Uncountable coordination

    perindopril/indapamid with lithium: increased with lithium and toxic lithium recovery.

    Perindopril and Aliskiren: Increase cardiovascular and death.

    perindopril with angiotensin receptor inhibitors: increased harmful effects.

    Perindopril with estramustin: Increased harmful effects.

    perindopril with potassium -keeping drugs: excessive hyperkalemia.

    amlodipine with dantrolene: risk of ventricular vibration, hyperkalemia.

    amlodipine with grapefruit: bioavailability, risk of hypotension.

    Special prudent coordination

    perindopril/indapamid with Baclofen: Increased hypotension effect.

    perindopril/indapamid with NSAID: The risk of reducing the effect of hypotension, increasing harmful effects.

    Perindopril with diabetes: increases the risk of hypoglycemia.

    Perindopril with diuretics does not hold potassium: The risk of excessive hypotension.

    Perindopril with diuretics holding potassium: The risk of obvious hyperkalemia.

    indapamid with peak -causing drugs: The risk of arrhythmia increases.

    indapamid glycoside supports: increased toxicity.

    amlodipine with CYP3A4 induction drugs: A amlodipine level may be reduced in plasma.

    • Storage

    Military troops under 30 ° C

    Keep pills out of vision and reach of children.

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