Trisova tab Dongkoo treat stable angina (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	20mg

Uses

Indications

Trisova Tablet is indicated in the following cases: Indications for adults in supplementary therapy/support for existing treatment for symptoms in stable angina patients with adequate control or non -tolerant patients with other angina treatment therapies.

Pharmacokology

Mechanism of action: Trimetazidin inhibits the oxidation of fatty acids by inhibiting Long - Chain 3 - Ketoacyl - CoA thiolase enzymes in ischemic cells, energy obtained during oxygen glucose requires less oxygen consumption than oxidation. Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effects: In patients with ischemic heart anemia, trimetazidin acts as a metabolic substance, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidin has anti -anemia effect but does not affect hemodynamics.

pharmacokinetic pharmacokinetics

trimetazidin is quickly absorbed and reached the peak concentration in plasma before 2 hours from drinking. The maximum concentration of the drug in plasma, after using a single dose of trimetazidin 20mg, reaches about 55ng/ml. The equilibrium of the medication in the blood is reached from 24 - 36 hours after repeating a dose and is very stable during treatment. With a 4.8 -liter distribution integral, the transition level of the drug is good for the tissue. Low protein mounting ratio, the measured value in vitro is 16 %. Trimetazidin's waste sale time is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking Trisova tab Dongkoo treat stable angina (10 blisters x 10 tablets)

How to use

Take oral, take medicine with meals.

Dosage

dose 20mg/time x 3 times/day.

Patients with average renal impairment (Creatinin 30 - 60ml/minute clearance)

Dosage recommended 20mg/time x 2 times/day, morning and evening (see more contraindications and caution when taking the drug).

Elderly patients

Elderly patients may have a higher level of trimetazidin sensitivity than normal due to the impaired kidney function by age.

For patients with average renal impairment (the clearine clearance of 30 - 60ml/minute): recommended dose is 20mg/time x 2 times/day, morning and evening.

Be cautious when calculating the dose for elderly patients (See also the contraindications and caution when taking the drug).

for children

The safety and effectiveness of trimetazidin in patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Should treat symptoms.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using trisova tablet , you may experience unwanted effects (ADR).

Common

Dizziness, headache, abdominal pain, diarrhea, indigestion, nausea and vomiting, rashes, urticaria, weakness.

rarely

Brushing chest drums, suspense, extra systolic, fast heartbeat, arterial hypotension, vertical blood pressure , can lead to discomfort, dizziness or fall, especially in patients being treated with anti -hypertension drugs, flushed.

Unknown side effects

Parkinson's symptoms (slow and difficult and difficult movement, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, can often recover after stopping the drug. Sleep disorders (insomnia, drowsiness). Constipation, external acne acne acne (AGEP), angioedema, grain leukemia, decreased crane, thrombocytopenic hemorrhage, hepatitis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trisova Tablet contraindicated in the following cases:

Hypersensitivity to the active ingredient or any excipients of the drug.

Be cautious when using

Avoid for pregnant and lactating women due to the lack of clinical research data for trimetazidine active ingredients.

Trimetazidine can cause or worsen Parkinson's symptoms (Run, slow and difficult exercise, increase muscle tone), so patients, especially elderly patients, need regular checks and monitoring. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, vacuum syndrome, tremor, unstable gait, it is necessary to immediately stop using trimetazidin.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the stop, it is necessary to consult neurologists.

may have a self, unstable gait or hypotension, especially in patients who are taking medications for hypertension.

Be careful when prescribing trimetazidin for patients with high sensitivity levels such as:

Patients with average renal impairment.

Patients over 75 years old.

The ability to drive and operate machinery

trimetazidin can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

Avoid for pregnant women.

Breastfeeding period

Drug interaction

There is no interaction with any drug. Trimetazidin is not an induction drug nor is a drug inhibiting the liver metabolic enzyme in the liver and thus is more likely to trimetazidin does not interact with many metabolic drugs in the liver.

Anyway, you still need to be careful to monitor when coordinating with some other drugs.

Storage

Cool dry storage, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

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