Trisula 20g skin cream An Thien Pharma treats skin infections

Dosage form Box x 20g
Specifications Gentamicin, clotrimazole, betamethasone dipropionate

Ingredient

Composition information	Content
Gentamicin	20mg
Clotrimazole	200mg
Betamethasone dipropionate	12.8mg

Uses

Indications

Trisula skin cream is indicated for treatment of allergic skin inflammatory lesions, bacterial infections or primary or non -superinfections:

Original or secondary skin infections due to gentamicin sensitive bacteria.

foundation mushrooms, surrounding nail inflammation caused by Candida albicans.

Psoriasis, contact dermatitis, neuritis, eczema with or without superinfection, seborrheic dermatitis, sun -caused dermatitis, itchy anus. Learning

Pharmacological group: Betamethasone and antibiotics; Belonging to the strong corticosteroid group (group III), combined with antibiotics. Used in the treatment of skin diseases.

ATC code: d07cc01.

trisula combines the activity of 3 substances: anti -inflammatory, antifungal and anti -infection.

betamethasone is a corticosteroid with anti -inflammatory, anti -itching and vasoconstrictic activity.

Gentamicin provides bactericidal effect on sensitive microorganisms: Streptococcus-Hemolytic group A, Staphylococcus aureus. Gram -negative bacteria: Pseudomonas Aeruginosa, Aerobacter Aerogenes, Escherichia Coli, Proteus Vulgaris and Klebsiella Pneumoniae.

Clotrimazole is an Imidazole derivative that has a fungicide effect due to the impact on the fungal cell membrane that causes cytoplasm. Sensitive to the strains of Candida Albicans, Trichophyton Floccosum, Microsporum Canis and Trichomonas Vaginalis.

Dynamic pharmacokinetics

betamethasone: After applying, especially when covered or when the skin is deep damage, corticosteroids can be absorbed enough to cause systemic effects. The level of skin absorption of local corticosteroid depends on many factors (used form, intact of the epidermal fence, the bandage).

The drug can be absorbed when the skin is normal and intact. Inflammable or infected skin may increase the absorption of drugs through the skin. Once the skin is absorbed, topical corticosteroids have the same pharmacostatic path like when using systemic corticosteroids.

When used on the spot, Clotrimazole can penetrate into the epidermis but the whole body absorption rarely occurs.

Clotrimazole metabolizes in the liver into non -active substance and is excreted through feces and urine.

Gentamicin: There is a report on the whole body absorption after use on the spot on the skin peeling, burning or in the wound. Selling time in plasma is 2-3 hours. Gentamicin is not metabolized and eliminated in the form of unchanged urine.

Before taking Trisula 20g skin cream An Thien Pharma treats skin infections

How to use

topical skin.

Dosage

Apply a thin layer of cream, covering the whole skin regularly 2 times/day (morning, dark). The duration of treatment depends on the level of spreading/localized and responding. Review diagnosis if not improved after 3-4 weeks.

Stop used if symptoms are sensitive to drugs or itching.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

overdose:

The use of topical corticosteroids for a long time can inhibit the function of the pituitary and adrenal glands, resulting in secondary adrenal insufficiency, which may have manifestations such as hypertension, Cushing disease.

When using Clotrimazole contains C, marked on the skin intact or damaged while the bandage for 6 hours, in the serum of these objects, the amount of clotrimazole measured is negligible (the detection limit is lower than 0.001 mcg/ml). So will not overdose when using clotrimazole on the spot.

Once the overdose of the gentamicin will not cause symptoms, but the use of too much or prolonged gentamicin on the spot can lead to superinfection by non -sensitive bacteria.

How to handle:

Symptomatic treatment. Symptoms during acute corticosteroid overdose can recover. Treatment of electrolyte imbalance (if necessary). In the case of chronic poisoning, corticosteroids should be eliminated slowly.

If superinfected by non -sensitive microorganisms, stop using Trisula and appropriate treatment.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Trisula, you may experience unwanted effects (ADR) such as:

Feeling pain, blistering, peeling, edema, urticaria, skin stimulation, skin color change, reduction reduction, itching, leaking, erythema. Statistics.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Trisula skin cream is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

If sensitive or irritated when applying trisula, you should stop using and treat appropriate symptoms.

Side effects when using whole corticosteroids include adrenal inhibition, which can also occur when using local corticosteroids, especially in infants and young children.

Cross allergy between aminoglycosides have been proven.

The whole body absorption when using corticosteroids and gentamicin on the spot will be increased when applying the drug on wide skin or using gauze, especially when used for a long time and torn the skin.

Avoid using gentamicin on open wounds and damaged skin because it can cause unwanted effects system, especially careful when used for children and babies.

The use of long -lasting antibiotics can cause excessive growth of non -sensitive microorganisms.

If this happens, stop using Trisula and treat appropriate symptoms.

Do not apply trisula into the eyes or skin around the eyes.

The use of topical corticosteroids in children is likely to cause the inhibition of the hypothalamus - pituitary - adrenal gland (HPA) and the higher external corticosteroid effect in adults due to the higher ability to absorb through the skin.

HPA axis inhibitors, Cushing syndrome, linear retarded, slow weight gain and intracranial hypertension have been reported in children using topical corticosteroids. Manifestations of adrenal inhibition in children include low plasma cortisol levels and no ACTH stimulation.

The manifestation of intracranial hypertension includes fontanel, headache and edema on both sides.

Autodium warning:

The ingredient containing stearyl alcohol, Cetyl alcohol can cause local reactions on the skin (such as contact dermatitis).

The ingredients containing methylparaben, propylparaben, propylene glycol are at risk of allergic reactions on the skin.

The effect of the drug on driving and operating machinery

The drug does not affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and nursing mothers

Pregnant women: There is no data on use of drugs on pregnant women, should only be used if the benefits are superior to the risk.

breastfeeding women: It is unclear whether the use of Clotrimazole, Gentamicin and Betamethasone leads to body absorption in sufficient concentrations to be detected in breast milk or not. It is necessary to consider stopping the medication or stop breastfeeding based on the importance of the drug for the mother.

Interactive drug

When used on the spot, the drug has no interaction.

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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