Trivastal Retard 50 Servier medicine for Parkinson's treatment (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Piribedil

Ingredient

Composition information	Content
Piribedil	50mg

Uses

indications

Trivastal Retard 50mg drug is indicated in the following cases:

Treatment of Parkinson's disease:

Use single therapy (treating diseases including tremor symptoms mainly).

or used in combination with dopamine therapy right from the beginning or combination of step two, especially on diseases with tremor symptoms.

Pharmacy

Pharmacological treatment group: Dopamine owner.

Piribedil is a dopamine owner (stimulating dopamine receptor and dopamine transmission paths in the brain).

In humans, the pharmaceutical impact mechanism proves by clinical pharmacological studies:

Stimulates the generation of electricity in the brain "dopamine" both when awake and sleep.

Clinical activity for different functions controlled by dopamine, this activity is shown by using mental behavioral evaluation scale.

Moreover, Piribedil increases blood flow in the thigh.

Dynamic pharmacology

Piribedil is quickly absorbed.

Maximum concentration achieved after taking Piribedil 1 hour.

The blood levels decreased by two phases: the first phase with the sale time of 1.7 hours, the second phase is slower, the sale time is 6.9 hours.

Piribedil metabolizes strongly with two main metabolites: a hydroxylation derivative and a dihydroxylation derivative. Piribedil is out of the urine: 68% of Piribedil absorbed the post through the kidneys in the form of metabolites, 25% of the bile.

The tablet contains 50mg of slow -released piribedil that allows the active ingredient to be absorbed and released in possible stickers.

Human pharmacokinetics studies have shown the 24 -hour therapeutic effect.

50% of the drug is exported in the urine at 24 hours and the entire amount of drugs will be exported after 48 hours.

Before taking Trivastal Retard 50 Servier medicine for Parkinson's treatment (2 blisters x 15 tablets)

How to use

Take oral use. Take the whole pill with half a cup of water, do not chew, take the medicine at the end of the meal.

Dosage

Treatment of Parkinson's disease:

In single therapy: dose from 150mg to 250mg, meaning from 3 to 5 capsules daily, divided into 3 to 5 times a day.

In auxiliary treatment for Dopa (Dopa Therapy): dose from 80mg to 140mg (about 20mg of piribedil for 100mg L.Dopa). If there is a small dose, tablets containing 20mg of Piribedil will be more suitable.

In case of increasing the dose to achieve treatment dose: Every 3 days, an additional 1 tablet.

There is no data on the use of Trivastal for children.

Dosage for each individual and prescribed by a doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Trivastal Retard 50mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Mental disorders: confusion, hallucinations, anxiety.

Nervous system disorders: dizziness, drowsiness.

Uncommon, 1/1000

Pentotic disorders: Hypotension, hypotension with vertical posture accompanied by fainting or fatigue or unstable blood pressure.

Rare

Nervous system disorders: Sleeping, movement disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Trivastal Retard 50mg drug contraindicated in the following cases:

History of allergies to Piribedil, or with any component of excipients.

Cardiovascular shock.

Acute myocardial infarction.

Combined with: Sedative anti -vomit, sedative, anti -psychotic (except Clozapine).

Be cautious when using

If you see suddenly the appearance of drowsiness or excessive sleep during the treatment period with Trivastal, you must contact your doctor.

let your doctor know if you or your family/ caregivers find you have an increase in the tendency and desire to behave unusually but cannot control, can harm you and others.

This symptom is called desire control disorders and may include behaviors such as gambling desire, over -eating or excessive phase, increasing thoughts and sexual desire. Your doctor may need to adjust the dose or stop the drug in older patients, the risk of falling, may be related to hypotension, suddenly sleeping, or a condition that needs to be concerned.

Due to the presence of sucrose, this drug is not used for patients with fructose intolerance, with poorly absorbent glucose and galactose syndrome, or the Sucrase-Isomaltase (rare metabolic disease) deficiency.

The ability to drive and operate machinery

using Trivastal may experience drowsiness or suddenly sleep. In this case, absolutely do not drive or participate in activities to be alert because there is a risk of serious accident or death for themselves and others (for example, operating machinery) until these signs disappear.

The pregnancy

This drug has been shown to pass through the placenta and distributed on the mouse fetus. Due to the lack of relevant data, this medication during pregnancy is not recommended.

The period of breastfeeding

Due to the lack of relevant data, this medication during breastfeeding is not recommended.

Drug interaction

This drug is not used in combination with some other drugs: anti -vomit drugs, sedative drugs, anti -psychotic (except for clozapine), tetrabenazine and drugs to prevent nausea and vomiting, soothing stress anxiety.

Storage

below 30 degrees c.

Other drugs

Disclaimer

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