Trosicam drug 7.5mg Alpex Pharma treat osteoarthritis pain (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Meloxicam

Ingredient

Composition information	Content
Meloxicam	7.5mg

Uses

indications

trosicam drugs are indicated in the following cases:

Treatment of osteoarthritis symptoms (arthritis, osteoarthritis).

Treatment of rheumatoid arthritis symptoms. Prostaglandin combination, reducing the formation of intermediate substances that cause inflammation. Meloxicam inhibits Prostaglandin synthesis in more effective inflammatory position in the stomach and kidney mucosa related to selective inhibition of COX - 2 more than COX - 1.

Pharmacokinetics

absorption

Good absorption through the gastrointestinal tract, bioavailability reaches 89% by oral. After taking 1 dose, the maximum concentration reaches after 5-6 hours, after a few stable doses achieved after 3-5 days. Using continuously for more than 6 months does not show any dynamic change, so it does not use for more than 6 months. The level of absorption of Meloxicam oral is constant when used with food.

Distribution

Meloxicam is attached to plasma proteins, mainly 99%albumin. Meloxicam diffuses in the epidemic, the concentration in joint fluid is nearly half of the plasma. The average distribution volume is 11 liters, 30-40% ranging between individuals.

Metabolism

Almost entirely through the liver, the main metabolite 5 ' - Carboxyloxicam (60% dose), formed by the oxidation of intermediate metabolites 5' - Hydroxymethylmeloxicam, less than the lower level (9% dose), CYP2C9 plays a major role in this transformation process, a small part through CYP 3A4. The enzyme activity peroxidase plays a role with the remaining substance accounting for 16%, 4% of the dose.

Elimination

Mainly metabolites, half through the kidney, half through the stool. Under 5% of daily dose is excreted without metabolism through feces. The average selling time is about 20 hours. The clearance of the total plasma is 8 ml/min.

Before taking Trosicam drug 7.5mg Alpex Pharma treat osteoarthritis pain (3 blisters x 10 tablets)

How to use

7.5 mg trosicam drugs are used for tablets on the tongue.

The tablet will dissolve slowly with saliva (do not chew or swallow the pill), swallow with 240ml of water.

If you have dry mouth, use water to moisten your mouth first.

How to open the blister: To remove the pill from the blister, tear in the shape v.

Dosage

Osteoarthritis: Doser 7.5 mg/day, if necessary, can be increased to 15 mg/day.

Rheumatoid arthritis: Using a dose of 15 mg/day, depending on the response can be reduced to 7.5 mg/day.

Age vertebra stiffness: Using a dose of 15 mg/day.

Patients over 65 years old, long -term treatment in rheumatoid arthritis and alive arthritis is 7.5 mg/day.

Children and adolescents

Patients are at risk of increasing harmful reactions: starting at a dose of 7.5 mg/day.

Patients with severe renal failure must be separated: no more than 7.5 mg/day.

No dose adjustment in clinical stabilized cirrhosis patients.

Maximum doses recommended: 15 mg/day. Do not overdose for the maximum recommended 15 mg/day.

Can break tablets 15 mg to use the dose of 7.5 mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using trosicam, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: indigestion, nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea.

Hematology system: Anemia.

Skin: itching, rash.

Central nervous system: dizziness, headache. cardiovascular: edema.

Uncommon, 1/1000

Digestive system: heartburn, esophagitis, stomach ulcers, duodenum, potential gastrointestinal bleeding.

Hematology system: leukopenia, thrombocytopenia. skin: stomatitis, urticaria.

Central nervous system: dizziness, tinnitus, chicken sleep.

Urinary - genital system: increased serum creatinine, serum urea.

Rare: 1/10000

Gastrointestinal system: gastrointestinal perforation, colitis, hepatitis, gastritis, hemorrhage, gastrointestinal ulcers can die.

Skin: Sensitive light, water glossy dermatitis, diverse persimmon, Steven - Johnson syndrome, poisoned epidermal necrosis.

Central nervous system: Confusion, loss of orientation, mood change.

Urinary - genital system: acute renal failure.

visual disorders: conjunctivitis, blurred vision.

Hypersensitivity: Evana, Anaphylaxis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Trosicam drugs contraindicated in the following cases:

Hypersensitivity to meloxicam, acetylsalicylic and other NSAIDs.

Patients with signs of asthma, nasal polyps, nervous edema or urticaria after using aspirin or other NSAIDs.

There is a history of ulcer/gastric pain.

Inflammation (Crohn's disease or ulcerative colitis).

Severe liver failure, severe kidney failure.

Recent gastrointestinal bleeding, recent blood vessel hemorrhage or other bleeding disorders.

Unbelievable heart failure.

Children and teenagers under 16 years old.

Pregnant or lactating women.

Pain in case of coronary artery bridge surgery.

Be cautious when used

Caution in patients with a history of digestive disease or being treated with anticoagulant drugs, which should be monitored with patients with symptoms of gastrointestinal tract. Should stop the drug when there is gastric ulcer, gastrointestinal bleeding.

Rarely have serious skin reactions such as flaking dermatitis, Steven - Johnson syndrome, poisoned epidermal necrosis related to the use of NSAIDs, which can be fatal, stop when there are signs of mucosal damage or any other signs of sensitivity.

NSAID may increase the risk of serious venous thrombosis, myocardial infarction and stroke, which can lead to death, the risk of increasing over time. High risk in patients with cardiovascular disease or cardiovascular risk factors.

NSAID inhibits the synthesis of prostaglandin of the kidneys - The substance that maintains kidney perfusion, in patients with blood flow and reduced kidney volume such as patients with heart failure, cirrhosis, nephrotic syndrome, NSAID will promote the loss of kidney, can recover when stopping the drug.

In rare cases, NSAIDs are the cause of interstitial nephritis, glomerulonephritis, nephropathy or nephrotic syndrome.

Do not take the dose greater than 7.5 mg of meloxicam for patients with end -stage renal impairment is taking hemorrhage, do not reduce the dose in patients with mild or medium renal failure (Creatinine clearance> 25 ml/ min).

Sleekly increases serum transaminase, if prolonged, it is necessary to stop Meloxicam.

Need to monitor patients sick, weak, suffer from poor side effects, older, people at risk of liver and heart failure.

NSAIDs holding potassium, salt, water will interfere with the effect of sodium diuretic of diuretics, which promotes or worsen heart failure, high blood pressure, need to monitor in this patient.

The ability to drive and operate machinery

Unreasoned.

Pregnancy

using Meloxicam can reduce fertility due to decrease in prostaglandin, not for women who want to get pregnant. Women who are difficult to conceive or are treating infertility should consider stopping meloxicam.

Contraindications during pregnancy due to the risk of cardiovascular malformations

In the last 3 months of fetus, the fetus may have heart, lung toxicity, renal dysfunction leading to renal failure with mothers and babies at the end of pregnancy, can prolong bleeding time and anti -platelet collection effect in low doses, inhibit uterine contractions leading to delay or prolonged labor.

breastfeeding period

Not used for nursing women.

Interactive drug

other prostaglandin synthetic inhibitors, other NSAIDs, aspirin, glucocorticoids and salicylate: Unit effect, increase the risk of ulcer, digestive bleeding.

Oral anticoagulant, anti -platelets, systemic heparin, thrombolytic drugs, SSRI SSRIs selective inhibitors: Increased risk of bleeding due to inhibition of platelet function, closely monitoring.

Lithium/methotrexate: NSAIDs reduce the excretion of lithium/methotrexate through the kidneys leading to increased plasma concentrations, if needed to monitor blood lithium/methotrexaterong levels.

birth control pills: Reduce birth control effects.

Diuretics: leading to acute renal failure in patients with dehydration, adequate drinking, need to monitor when combined.

Hypertension: Reducing the effect of treating hypertension due to inhibition of vascular dilatation of prostaglandin.

Transfer inhibitors: The force causes a decrease in glomerular filtration, which can cause acute renal failure in patients with renal failure.

cholestyramin attached to meloxicam in the gastrointestinal tract eliminates Meloxicam faster.

Cyclosporin: Increased kidney toxicity.

Storage

Store at temperatures below 30ºC.

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