Trymo Raptakos drug treatment for duodenal ulcer, gastritis (14 blisters x 8 tablets)

Dosage form Box of 14 blisters x 8 tablets
Specifications Bismuth subcitrate

Ingredient

Composition information	Content
Bismuth subcitrate	120mg

Uses

Indications

Drugs trymo are indicated in the following cases:

Treatment duodenum ulcer . In the therapy (with metronidazole and tetracyclin or amoxicillin) to eliminate Helicobacter pylori. Medicine takes effect in reducing symptoms in patients with stomach and duodenal ulcer. The drug also increases the speed of gastric and duodenal ulcers. The effect is different from other anti -peptic ulcer drugs including H2 receptor anti -receptors .

The following pharmacological effects have been observed in experimental animals:

Due to the effect of stomach acid, oxid bismuth in CBS precipitates into a firm layer on the digestive mucosa. Enterococcus, Staphylococcus, Pseudomonas, therefore, transforms the

bacteria in the digestive tract. each other. The formation of this complex layer at the ulcer has the effect of disperse the dispersion of hydrochloride acid.

At the pH of less than 5, Trymo forms the precipitate of oxyx choc choc choc chloride and citrate bismuth. Due to the chelat connection, protein degenerative products along with precipitated substance from Trymo form an insoluble layer at the ulcer. Heaven. It is found that bismuth settles on the surface and inside the bacteria.

The effect of Trymo is entirely at the site of the ulcer. However, there is also a very small amount of bismuth absorbed through the digestive tract. The initial absorption depends on the dose and reaches the level of dynamic balance (equal level) after 4 weeks of taking the drug at the usual dose of 480 mg/day. Next concentration in blood or urine does not increase after 5 and 6 weeks. The average concentration is only 7 ng/ml, much lower than the alarm concentration of 50 - 100 ng/ml.

Distribution

Animal studies show that most of the absorbing bismuths go to the kidneys and the concentration in other organs spending is traces. For experimental dogs using CBS for 3 weeks with a dose of 20 times higher than the recommended dose in humans, Bismuth levels in tissues are surveyed by optical density measurement shows that the kidney contains 34.3 ppm bismuth and other organs to spend. Specifically: the stomach 4.3 ppm, liver 2.1 ppm, spleen 0.7 ppm, lymph nodes of intestinal suspension 1.6 ppm, blood below 0.5 ppm. There is no data on the distribution of Trymo in human tissue. Do not apply bioavailability because Trymo works on the spot.

Elimination

Most of the bismuth in the trymo is excreted in feces in the form of sulphat bismuth. The very small amount of bismuth can absorb excretion through the kidney. The speed of excretion through the kidneys is slow, about 2.6% per day; On average, urine excretion is about 411 - 639 mcg/24 hours for 4 - 6 weeks of treatment. Therefore, after each time, Trymo needs to spend 2 months for the body to eliminate the drug before considering the application of a new course with Trymo.

Before taking Trymo Raptakos drug treatment for duodenal ulcer, gastritis (14 blisters x 8 tablets)

How to use

oral medication, drink at the blank, half an hour before meals, swallow whole tablets without chewing pills.

Dosage

2 capsules each time, 2 times a day.

Trymo is first used for 4 weeks and if necessary, up to 8 weeks.

Do not use Trymo as a maintenance therapy after a maximum of 8 weeks of treatment.

If a continued treatment is planned to leave at least 8 weeks before the new treatment.

If used in triangle therapy, drink trymo 1 tablet each time, 4 times a day for 2 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, there has been a notice of renal failure , brain disease and neurotoxicity after acute or chronic overdose.
It is currently unknown how the optimal treatment for the overdose of the Bismuth. Gastroesaniasis should be washed, erased and adjusted electrolyte water, even when the patient was late. Chelate connectors can be significantly taken at the early stage after oral and 2.3-Dimercapto-1-Propan Sulfonic dose of 100 mg, 3 times a day can increase bismuth removal in the kidneys and reduce bismuth levels in the blood. The unproven hemorrhage is shown to be able to clear the bismuth at tissue or not.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using trymo , you may experience unwanted effects (ADR).

Nausea, vomiting and diarrhea are reported to be reported when using Trymo. headache and dizziness are recorded by some researchers. Black feces due to bismuth sulphide excretion.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trymo drug contraindicated in the following cases:

Severe renal failure.

Women who are pregnant and lactating.

Children.

Caution when using

although there is no report on bismuth brain disease after using bismuth subcitrate in the treatment dose, still must always remember this risk and avoid overdose. For the same reason, not for long -term use (maintenance therapy).

Do not use overdue drugs on the label.

The ability to drive and operate machinery

trymo does not affect the ability to drive and operate machinery.

Pregnancy

Do not recommend trymo for pregnant women.

Breastfeeding period

Medicinal interaction

iron absorption, calcium or tetracycline vowed to be reduced if used at the same time as Trymo.

Antacids or milk with Trymo can connect chelate to the drug and affect the effect of bismuth subcitrate. Therefore, avoid food or antacids for 30 minutes before or after Trymo.

Storage

Store at a temperature not exceeding 30 ° C, avoiding light.

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