TUX-ASOL 60mg Medisun treat bronchial and lung diseases with dry cough (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Levodropropizin

Ingredient

Thành phần cho 1 viên

Composition information	Content
Levodropropizin	60mg

Uses

indications

The drug is indicated for adults and children over 12 years of treatment of bronchial diseases that are accompanied by dry cough.

Pharmacology

Pharmacological group: Cough reduction drug.

Code ATC: R05DB27.

Mechanism of action

levodropizin has the effect of reducing cough due to inhibition of impact on fibers c.

Levodropizin is a peripheral cough reduction drug on bronchial gases, accompanied by anti -allergy and anti -bronchial effects.

Pharmaceutical effect

In vitro, the drug has been shown to inhibit the release of levodropropizin on the bronchi system by inhibiting bronchospasm caused by histamine, serotonin or bradykinin.

Dynamic pharmacokinetics

on humans, levodropropizin is absorbed and distributed quickly after drinking.

Selling time is from 1-2 hours. Levodropropizin is excreted mainly in urine. The drug is eliminated in a constant form and in the form of metabolites such as sued levodropizin and p-hydroxylevodropizin free or combined form. Levodropropizin and its metabolites are eliminated in urine about 35% of the dose within 48 hours.

Dynamic studies have been conducted on rats, dogs and humans. The absorption, distribution, metabolism and elimination in all three species are the same with oral bioavailability of over 75%.

The ratio of cohesion with plasma proteins in humans is negligible (11-14%) and can be compared to the visual values on dogs and mice.

The tests in which the drug is continuously used showing that the treatment for 8 days (3 times/day) does not affect the absorption and elimination properties of the drug. Therefore, it is possible to eliminate the accumulation and self -metabolism of the drug.

Radioactive recovery rate after drinking is 93%.

There is no significant change in the pharmacokinetic properties of drugs in children, elderly patients with moderate or severe renal failure.

Before taking TUX-ASOL 60mg Medisun treat bronchial and lung diseases with dry cough (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults and children over 12 years: 1 tablet (equivalent to 60 mg Levodropizin)/time, 1-3 times/day apart at least 6 hours apart.

Use the drug until the symptoms are cough, but not more than 2 weeks. If the cough symptom does not go away after this time, the patient needs to stop using the drug.

What to do when overdose?

There have been a few cases of overdose in children 2-4 years old. These cases have no consequences.

In most cases, patients with symptoms of abdominal pain and vomiting. There have been 1 case of sleeping and oxygen saturation decreased after the dose of 600 mg. In case of overdose with clinical symptoms that are clear, it is necessary to start symptomatic treatment as soon as possible and use appropriate common treatment measures (such as gastric lavage, use of activated carbon, infusion, ...).

What to do when forgetting a dose?

Side Effects

Based on the estimate of the number of patients exposed to levodropropizin from the amount of drugs sold and on the basis of spontaneous reports, less than 1 of 500,000 patients with unwanted effects of the drug.

The undesirable effect in the table below is listed according to the classification of Meddra's organs with the following conventional frequency: Very common (> 1/10), common (21/100 to Sort of Agency System frequency Nursing is very rare coma due to hypoglycemia (1 case
has been reported in elderly female patients
taking oral hypoglycemic drugs
) The nervous system is very rare

headache, tremor, paresthesia, drowsiness; Fainting
Slip-Co shock (1 case reported)
Small epilepsy (1 case has been reported by
) Fast
arrhythmia (1 case has been reported
) Steamed Disorders of the digestive system very rare Abdominal pain, abdominal pain, nausea, vomiting, diarrhea
Bong inflammation (1 reported case)
Pressure (1 reported case) Hepatitis (1 case has been reported in elderly female patients taking oral hypoglycemic drugs) Bones and connective tissue are very rare muscle weakness encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

sensitive to the active ingredient or any ingredient of the drug.

Patients with bronchial secretion.

impaired mucus system function and feather activity (Kartagier syndrome, switching disorders).

Severe liver function impairment.

Pregnant and lactating women (see the use of drugs for pregnant and lactating women).

Be cautious when using

There is no significant change in the pharmacokinetic properties of the drug in children.

There is no significant change in the pharmacokinetic properties of the drug on the elderly, so it is not necessary to change the dose or the distance to use the drug on this patient.

However, due to the sensitivity to different drugs is different in the elderly, levodropropizin needs to be used carefully in these patients.

Be careful when taking the drug for the following objects:

Patients with severe renal impairment (creatinine clearance below 35 ml/min).

Because there is no data on the effects of food on the absorption of the drug, the drug should be used away from the meal (when hungry).

This drug contains lactose. Patients with rare genetic problems are galactose intolerance, lactase deficiency or glucose-galactose abutment should not be taken.

The effect of drugs on driving and operating machinery

levodropizin slightly affects the ability to drive or operate machinery. Maybe sleepy after taking the drug (see the unwanted effect of the drug).

Use drugs for women during pregnancy and lactation

Pregnant women, fertility

Studies on the risk of teratogenicity, fertility and reproductive process as well as studies during the birth and postpartum period do not show any toxicity of the drug.

However, due to animal toxic studies at a dose of 24 mg/kg, there is a slow weight gain and growth, and levodropropizin can pass the fetal fence in mice, so do not use medication for pregnant women or pregnant women.

breastfeeding women

In mice studies, the drug is still in breast milk after 8 hours of taken. Therefore, contraindicated levodropropizin for nursing women.

Drug interaction

does not observe any interaction between levodropropizin and benzodiazepin in clinical trials. However, be careful when taking the drug simultaneously with sedative drugs, especially in patients sensitive due to the risk of sedative of the drug (see the warning and caution when taking the drug).

Clinical studies show that there is no interaction between levodropropizin and bronchodilator treatments such as beta-2 receptor antagonists, methylxanthin and derivatives, corticosteroids, antibiotics, phlegm and anti-histamine drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.