TW3 cough syrup helps reduce cough, sputum, anti -allergy (60ml)

Dosage form Syrup
Specifications Box x 60ml
Ingredient Dextromethorphan, chlorpheniramin maleat, Guifenesin, ammonium chloride
Indication Dry cough, cough with talks, runny nose, watery eyes, rashes, stuffy nose
Contraindication Pregnancy, drug allergy, narrow -angle glaucoma

Ingredient

Composition information	Content
Dextromethorphan	60mg
Chlorpheniramin Maleat	15.96mg
Guiifenesin	600mg
Ammonium chloride

Uses

indications

TW3 cough syrup is indicated for reducing cough symptoms in the following cases:

cough due to colds, flu, dry cough, allergic cough, runny nose, stuffy nose, tearing and rashes. Dextromethorphan is used to reduce temporary cough due to mild stimulation in bronchial and throat as usual cold or inhalation of stimulants.

Dextromethorphan is most effective in the treatment of chronic cough, without sputum. The drug is often used in combination with many other substances in the treatment of the upper respiratory symptoms.

Clorpheniramin Maleat is an antihistamine with very little sedative effects. The antihistamine effect of chlorpheniramine through the closing body competes the H1 receptors of the acting cells.

Guaifenesin is a phlegm, it stimulates or facilitates the removal of the respiratory secretion through increased mass and makes the mucus less sticky than sputum.

Ammonium chloride causes mild irritation on the bronchial mucosa to increase the secretion of the respiratory greasy, reducing dryness and pain of the respiratory tract.

Dynamic pharmacokinetics

Dextromethorphan is quickly absorbed through the digestive tract and works within 15-30 minutes after drinking, lasting about 6-8 hours (12 hours with slow liberation). The drug is metabolized in the liver and excreted through the urine in the form of constant and Demethyl metabolites, among them dextrorphan also has a slight cough reduction effect.

chlorpheniramin maleat absorbs well when taken and appears in plasma within 30-60 minutes. Plasma peak concentration is about 2.5 - 6 hours after drinking. Low bioavailability, reaching 25-50%. About 70% of the drug during the circulation associated with the protein. The distribution volume is about 3.5 liters/kg (adults) and 7 - 10 liters/kg (children).

chlorpheniramin maleat is fast and highly metabolized. The drug is excreted mainly in urine in the form of constant or metabolic, the excretion depends on the pH and the urine flow. Only a small amount is seen in the feces. The sale time is 12 - 15 hours and in patients with chronic renal failure.

Guaifenesin absorbs easily by oral, the sale time is 1 hour. Guiifenesin metabolized through the liver and excreted mainly through the kidneys.

Ammonium chloride quickly absorbed through the gastrointestinal tract when used by oral. Ammonium chloride metabolizes in the liver into urea and hydrochloride acid; Elimination through the kidney.

Before taking TW3 cough syrup helps reduce cough, sputum, anti -allergy (60ml)

How to use

Take oral use.

Dosage

Take 3 times/day or as instructed by a physician.

Children from 2 - 6 years old: 5 ml (1 teaspoon).

Children from 7 - 12 years old: 10 ml (2 teaspoons). Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Nausea, vomiting, drowsiness, blurred vision, eyeball, urination, numbness, hallucinations, loss of air conditioning, respiratory failure, convulsions.

Treatment

Support, use Naloxon 2 mg intravenously, for repeated use if the total dose of 10 mg.

chlorpheniramin maleat

Symptoms

Sediment, inverse stimulation often central nervous system, mental rebellion, seizure, apnea, convulsions, anti -secretion effects Acetylcholin, hypertonic reaction and cardiovascular collapse, arrhythmia.

Treatment

Gastric or vomiting with ipecacuanha syrup, then use activated carbon and bleach to limit absorption. In the case of antipyretic and arrhythmia, it should be actively treated. Diazepam or intravenous phenytoin may be useful and treat convulsions. Can blood transfusion in heavy cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using TW3 cigarette medicine, you may experience unwanted effects (ADR).

dextromethorphan

Common, ADR> 1/100

Body: Fatigue, dizziness.

circulating: tachycardia. digestive: nausea. skin: flushed.

Uncommon, 1/1000

Skin: urticaria.

Rare, ADR

Skin: Ban.

Clorpheniramin Maleat

Common, ADR> 1/100

Central nerve: Sleeping, sedation.

digestive: dry mouth.

Rare, ADR

Body: Dizziness.

digestive: Nausea, mild digestive disorders. Neurological: The sedative effect changes from the vigorous to deep sleep may occur but will decrease after a few days. Mild central neurological disorders.

Instructions on how to handle ADR

When experiencing the side effects of the drug, the doctor should notify the unwanted effect when using the drug.

Warnings

Contraindicated

Siro cough cough TW3 contraindicated in cases of sensitivity to any ingredients of the drug.

Be cautious when using

dextromethorphan: Patients with coughs have too many sputum and chronic coughs in smokers, asthma or air overflow; People at risk or respiratory decline; Using dextromethorphan is related to histamine release and should be cautious with children with allergies.

Clorpheniramin Maleat: The sedative effect of chlorpheniramin increases when drinking alcohol and using simultaneously with other sedatives, people with glaucoma; Elderly (> 60 years old) because these people often increase sensitivity to anti -secretion effect acetylcholin.

The ability to drive and operate machinery

affect the ability to drive and operate machinery due to drugs containing chlorpheniramin maleat, causing chicken sleep, dizziness, dizziness, blurred vision. Therefore, not driving and operating machinery during the time of using the drug.

Pregnancy

Because GuaiFenesin passed the placenta, it is not used for pregnant women. Chlorpheniramin is only used for pregnant women when necessary. Currently, the effect of dextromethorphan for pregnant women is unknown, so they only use when necessary and have a doctor's instructions.

The period of breastfeeding

is only used when necessary and must follow the instructions of the physician. Clorpheniramin can be secreted through breast milk and inhibit milk. Because antihistamine drugs can cause serious reactions to breastfed babies, should consider or not breastfeed or do not take the drug, depending on the level of the drug's necessary to the mother.

Drug interaction

for chlorpheniramin maleat

Monoamine oxidase inhibitors (Mao) prolonged and increased the anti -secretion effect of acetylcholin of antihistamine drugs.

ethanol or sedative drugs can increase the central neurological inhibition effect of chlorpheniramin.

chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

For dextromethorphan

Avoid use with Mao inhibitors.

Simultaneously used with central neurological inhibitors can enhance the central neurological inhibitor of these drugs or of dextromethorphan.

Quinidine inhibits cytochrom P4502D6 can metabolize the metabolism of dextromethorphan in the liver, increasing the concentration of this substance in serum and increasing the unwanted effect of dextromethorphan.

Storage

Store in a cool dry place, the temperature does not exceed 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.