Tydol 500 OPV medicine relieves pain and antipyretic from mild to medium (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	500mg

Uses

Indications

Tydol 500 drugs are indicated in cases of treatment:

Reduce fever.

Treatment of mild -to -medium -sized pain includes: headache , colds and flu, sore throat, menstrual pain, pain after vaccination or tooth extraction, migraine , osteoarthritis pain.

Pharmacy

Acetaminophen is an effective analgesic - antipyretic drug that can replace Aspirin, but acetaminophen does not have the effect of inflammatory treatment. With equal doses, acetaminophen has analgesic, reducing fever similar to Aspirin.

Acetaminophen reduces body temperature in fever but rarely reduces body temperature in normal people.

Acetaminophen, with treatment, less impact on the cardiovascular and respiratory system, does not change acid-base balance, does not cause irritation, scratches or stomach bleeding as when using aspirin and salicylate.

When overdose of acetaminophen, n-acetyl-p-benzoquinoneimin metabolism is toxic to the liver.

Normal dose, acetaminophen well tolerated does not have many serious side effects like aspirin. However, acute overdose (over 10 g) will damage the liver.

pharmacokinetics

absorption: Acetaminophen is quickly absorbed from the digestive tract with peak concentration in plasma reaching about 10-60 minutes after drinking.

Distribution: Acetaminophen is distributed mostly in the body's tissues. Acetaminophen through the placenta and present in breast milk. Integrated with negligible plasma proteins at conventional treatment concentrations but binding will increase as the concentration increases. Selling time is about 1-3 hours.

Metabolism and elimination: Acetaminophen mainly metabolizes in the liver and eliminates urine in the form of glucuronid conjugate (60-80%) and sulphate conjugate (20-30%). Less than 5% is excreted in constant form. A small part (less than 4%) is metabolized under the effect of Cytochrom P450 into metabolic. In case of poisoning due to high doses, the amount of metabolites increases and is detoxified by combined with glutathion.

Before taking Tydol 500 OPV medicine relieves pain and antipyretic from mild to medium (10 blisters x 10 tablets)

How to use

Tydol 500 mg oral drugs.

Dosage

Do not use acetaminophen to treat pain relief for more than 10 days in adults and more than 5 days in children, unless the physician is instructed. Do not use acetaminophen for adults and children to treat high fever on their own (over 39.5ºC), fever lasting for more than 3 days, or recurrent fever, unless it is instructed by a physician.

Take medicine every 4-6 hours if needed.

Adults and children from 12 years old: take 1-2 capsules/ time. Do not use more than 8 tablets/ day.

Minimum distance between 2 drinks: 4 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Nausea, vomiting, anorexia, pale, abdominal pain.

Overdose of acetaminophen can cause liver failure. Excessive doses of over 10 g in adults (lower dose in alcoholics) and over 150 mg/kg of children's weight, single dose may cause liver cell decomposition that leads to complete necrosis and non -recovery, metabolic acidosis, brain disease leading to coma or death.

Emergency treatment

Early diagnosis is important in the treatment of overdose acetaminophen. When severe poisoning, it is important to treat positive support. Gastric lavage is needed in any case, preferably within 4 hours after drinking. The main detoxification is sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver.

n-acetylcysteine works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking acetaminophen.

Treatment with n-acetylcystein is more effective when giving the drug for less than 10 hours after taking acetaminophen.

When drinking, dilute N-acetycystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing.

Give N -acetylcystein oral at the first dose of 140 mg/ kg, then another dose, each dose of 70 mg/ kg each 4 hours apart. Termination of treatment if acetaminophen test in plasma shows the risk of low liver toxicity.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Tydol 500 drugs , you may experience unwanted effects (ADR).

Uncommon, 1/1000

rash, nausea, vomiting, hematopoietic disorders (neutropenia, all bloody hemoglobin, leukopenia), Anemia , kidney disease, kidney toxicity when taking long -term drugs.

Rare, ADR

Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tydol 500 mg drug contraindicated in case of hypersensitivity to acetaminophen, anemia patient, heart disease, lung, kidney, deficiency G6PD, liver failure .

Caution when using

Doctors need to warn patients on serious skin reaction signs such as Steven - Johnson syndrome (SJS), Poisonous Skin Dyscolic Syndrome (Ten), or Lyell Syndrome, Systemic Syndrome of Governmental Bodhisattva (AGEP).

Consult your doctor if the symptoms do not get better or in the case of a patient with severe liver or kidney failure.

People with phenylceton - urinary, anemia in advance and drink a lot of alcohol.

Not used with other drugs containing acetaminophen.

The ability to drive and operate machinery

No report

Pregnancy

Acetaminophen belongs to the group b.

Not yet determined the safety of acetaminophen when used for pregnant women. Only use acetaminophen in pregnant people when really necessary.

Breastfeeding period

Medicinal interaction

long -term oral taken with high doses of acetaminophen increases the effects of cooumarin and indandion derivatives.

Simultaneous use of acetaminophen and phenothiazine is likely to cause serious fever.

Take a lot of alcohol and long -term, increases the risk of liver toxic Qcetaminophen.

Anti -seizures (including Phenytoin, Barbiturat, carbamazepin ), Isoniazid can increase the toxicity of acetaminophen on the liver.

Storage

At temperatures below 30ºC, in a dry place, avoiding light.

Other drugs

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