Tydol 650 OPV medicine relieves pain and reduces fever from mild to medium (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Sore throat, sinusitis, fever, headache, migraine, body aches
Contraindication Cirrhosis

Ingredient

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Composition information	Content
Acetaminophen	650mg

Uses

indications

Tydol 650 drugs are indicated in the following cases:

A reduction of fever.

Acetaminophen is an effective analgesic, reducing fever that can replace Aspirin, but acetaminophen does not work to treat inflammation.

At the same dose, acetaminophen has the same fever -reducing pain effect as aspirin.

Acetaminophen reduces body temperature in fever but rarely reduces body temperature in normal people.

acetaminophen, with treatment, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using aspirin and salicylate.

When overdose of acetaminophen, n-acetyl-P-benzoquinonimin metabolites cause heavy toxicity to the liver. Normal doses, acetaminophen well tolerated without many serious side effects like aspirin. However, acute overdose (over 10 g) will damage the liver.

Dynamic pharmacokinetics

Acetaminophen is quickly absorbed from the digestive tract with peak concentration in plasma reaching about 10 - 60 minutes after drinking. Acetaminophen is distributed in most body tissues.

acetaminophen through the placenta and present in breast milk. Integrated with negligible plasma proteins at conventional treatment concentrations but binding will increase as the concentration increases.

Acetaminophen's waste sale time varies from about 1 to 3 hours. Acetaminophen is metabolized mainly in the liver and excreted in urine mainly in the form of glucuronid complex (60 - 80%) and sulphate conjugate (20 - 30%). Less than 5% is excreted in constant form. A small part (less than 4%) is metabolized under the effect of Cytochrom P450 into a substance.

In case of poisoning due to high doses, the amount of metabolites increases and is detoxified by combined with glutathion. Acetaminophen is n-hydroxylation by cytochrom P450 to create N-acetyl-Benzoquinonimin (NAPQ), a highly reactive intermediate. This metabolic substance normally reacts with sulfhydryl groups in glutathion and is dull.

However, if taking high doses of acetaminophen, this metabolite is formed in sufficient amount to exhaust the glutathion of the liver, in that situation, NAPQ is not in combination with glutathion toxic to liver cells, leading to inflammation and can lead to liver necrosis.

Before taking Tydol 650 OPV medicine relieves pain and reduces fever from mild to medium (10 blisters x 10 tablets)

How to use

Tydol 650 Tablets of oral film tablets.

Dosage

The usual dose of medication every 4 - 6 hours if needed.

Adults: take 1 tablet. Do not use more than 6 tablets/24 hours.

Children from 7 to 12 years old: Take 1/2 tablets. Do not use more than 3 tablets in 24 hours.

The minimum distance between 2 drinks: 4 hours.

Note:

Do not use medication to treat pain for more than 10 days in adults and more than 5 days in children, or high fever (39.5 ° C) for more than 3 days unless the doctor's prescribed.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

Remember to bring the remaining medication label or the remaining medication for the doctor to know the drug you used.

What to do when you forget a dose? If the time is near the next dose, skip the forgotten dose and use the next dose to the normal plan. Do not double the dose.

Side Effects

When using Tydol 650, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

DA: rash.

digestion: Nausea, vomiting. Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), Anemia .

Kidney: Kidney disease, kidney toxicity when taking long -term drugs.

rare, ADR

Body: Hypersensitivity reaction.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tydol drugs contraindicated in the following cases:

Patients with hypersensitivity to acetaminophen or any ingredients of the drug.

Severe liver failure.

Caution when using

Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten), or Lyell syndrome, acute foreign pustular syndrome (AGEP).

Consult your doctor if the symptoms do not get better or in case the patient has severe liver or kidney failure.

People with phenylceton - urinary, anemia in advance and drink a lot of alcohol. Do not use with other drugs containing acetaminophen.

Sometimes there are skin reactions including itchy and urticaria; Other sensitive reactions include laryngeal edema, angioedema and anaphylactic reactions that can rarely occur.

Platelet reduction, leukopenia and all bloody hemoglobin have occurred with the use of p-aminophenol derivatives, especially when used for large doses. Neutral leukopenia and platelet hemorrhage you have occurred when using acetaminophen.

Rarely loss of granulocytes in patients using acetaminophen.

Drinking plenty of alcohol can cause increased toxicity to the liver of acetaminophen, should avoid or limit drinking alcohol.

The ability to drive and operate machinery

has not recorded a adverse reaction report or no research on the effects of the drug on the ability to operate machinery, train driving, higher working people and other cases.

Pregnancy

Acetaminophen belongs to group B. Animal studies do not detect any harm to pregnancy and the development of pregnancy embryos. Only use acetaminophen in pregnant people when really necessary.

The period of breastfeeding

Human studies have not seen harmful manifestations for mothers and breastfeeding children.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Long -doses of high -dose acetaminophen increases the anticoagulant effects of cooumarin and conducting indandion.

Simultaneous use of acetaminophen and phenothiazin capable of causing serious fever damage.

Drinking too much alcohol and long -term increases the risk of acetaminophen toxic to the liver.

Anti -seizures (including Phenytoin, Barbiturat, carbamazepin ), Isoniazid can increase the toxicity of acetaminophen on the liver.

Storage

At temperatures below 30 ° C, in a dry place, avoiding light.

To be out of reach of children.

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