Ubiheal 100 Nam Ha medicine treats sensory disorders caused by diabetes neuropathy (5 blisters x 6 tablets)

Dosage form Box of 5 blisters x 6 tablets
Specifications Alpha Lipoic Acid

Ingredient

Composition information	Content
Alpha Lipoic Acid	100mg

Uses

Indications

Ubiheal 100 is indicated in the case of treatment of sensory disorders caused by diabetes.

Pharmacokology

alpha lipoic acid (ALA) is the same substance as vitamins, but is endogenous formation, the function of a coenzyme in oxidation reaction forming carbon dioxid of alpha keto acid.

Due to diabetes causing hyperglycemia, there is a glucose cohesion into the proteins of blood vessels that form substances called "the last product of the progressive glycosylation process". This process leads to a decrease in brain blood flow, lack of brain oxygen, ischemia, leading to an increase in the production of free oxygen roots, causing peripheral nerve damage.

Survey on mice shows that ALA participates in biochemistry leading to diabetes caused by streptozotocin by reducing the formation of "the last products of progressive glycosylization", improving the brain circulation, increasing glutathion's antioxidant level, which is antioxidants for antioxidants for free radicals in diabetic diseases diabetes .

The observed results in the experimental conditions show that the function of peripheral nerves can be improved by ALA. This is related to the sensory disorders of diabetic multi -neuropathy that manifests itself as unusual or inductance, such as a burning sensation, pain, numbness, cow ants.

In a study with Placebo, there was a beneficial effect of ALA for the symptoms surveyed as a burning sensation, abnormal, numbness, cow ants.

pharmacokinetics

Absorption: ALA is quickly absorbed after drinking. Bioions are used for oral use reaching 20% compared to intravenously.

Distribution: Because the drug is quickly distributed into tissues, ALA's semi -discharged time is about 25 minutes.

ALA's relative bioavailability when using oral tablet is more than 60% compared to oral solution. The plasma concentration is measured about 4 µg/ml after 0.5 hours after taking 600 mg of ALA.

Using the method of marking radiation bronze in animal experiments (mice, dogs) shows 80-90% of the drug is excreted in the form of metabolites in the kidneys. For people who only find a small amount of unused substances in the urine. Biological changes occur mainly due to oxidation of short chain (beta oxidation) and/ or methylation processes of corresponding thiol substances.

Before taking Ubiheal 100 Nam Ha medicine treats sensory disorders caused by diabetes neuropathy (5 blisters x 6 tablets)

How to use

Ubiheal 100 capsules should take whole tablets with a sufficient amount of water when hungry.

Food can reduce the absorption of the drug if used simultaneously. Therefore, patients need to keep hungry stomachs when taking the drug and the right time to take the drug is 30 minutes before meals.

Dosage

Dosage daily drink 2-3 times, 2 tablets of Ubiheal 100 (equivalent to 400-600 mg of thioctic acid), drink about 30 minutes before eating.

In the case of serious sensory disorders, the injection therapy with alpha lipoic acid can be conducted first.

Due to diabetic neuropathy is a chronic disease, long -term treatment may be required. The basic foundation of diabetic neuropathy is the optimal blood sugar control.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

In case of overdose, nausea, vomiting and headache may occur.

After intentionally and inadvertently drink large amounts of 10 g to 40 g to 40 g of acid with alcohol, severe poisoning and sometimes deadly cause. Signs of clinical poisoning can first manifest in mental disorders or consciousness disorders, typically developing general seizures and lactic acid infections.

In addition, reducing blood glucose, shock, globulin muscle melting, scattered blood thrombosis (dic), bone marrow weakness and multi -organs are described as a result of high doses of high -dose acid.

Treatment

In case of suspicion of severe poisoning caused by Thioctic Acid (such as a dose> 60 tablets of 100 mg in adults and> 50 mg/kg of weight in children) immediately takes patients to the medical authority with basic emergency conditions for poisoning cases (such as vomiting, gastric wash, use activated carbon, etc.).

Treatment of general seizures, lactic acid infections and other life -threatening consequences of toxicity need to be performed with modern supporting care principles and symptomatic treatment. The benefits of hemorrhage and peritoneal fertilizer or filtering methods to eliminate examsoctic acid do not give sure.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Ubiheal 100 , you may experience unwanted effects (ADR).

Rarely 1/10000 ≤ ADR

Gastrointestinal disorders: Nausea, vomiting, stomach pain, bowel pain and diarrhea .

Hypersensitivity reactions: allergic reactions such as rash, urticaria and itching.

neurological diseases: Change and taste disorders.

General disorders: Because sugar metabolism can be improved in diabetes patients, hypoglycemia may occur. There have been reports on symptoms such as dizziness, dizziness, sweat, headache and visual disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ubiheal 100 contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Not studied in children and teenagers, do not use Ubiheal 100 with these objects.

Be cautious when using

Patients with diabetes and glucose intolerance should be cautious when taking the examinocy acid because Thioctic Acid can reduce blood sugar. Blood sugar should be checked and adjust the dose of diabetes necessary to avoid blood glucose.

Soybean oil, nipazin, nipazol, tartrazin gold in the drug can cause allergic reactions.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There is no data on the use of drugs in pregnant women, only drugs should be used if the benefits are superior to the risk.

Pregnant women should treat with thioctic acid only when they have followed in accordance with the instructions of the physician, even if the toxicity studies with the reproductive system do not indicate any results that affect fertility and embryo development and no signs that cause toxicity to the fetus.

The period of breastfeeding

Women who breastfeeding should be treated with pooctic acid only when they have followed in accordance with the instructions of the physician, even if the toxic studies with the reproductive system do not give any results affecting fertility.

There is no case of examinations that can go into breast milk.

Medicinal interaction

loss of activity of cisplatin when taking drugs with alpha lipoic acid. Alpha Lipoic Acid has the ability to create metal complexes, so it should not be used simultaneously with metal compounds (such as iron -containing preparations, magnesium -containing preparations, dairy products due to calcium containing calcium). If alpha lipoic acid during the day is taken 30 minutes before breakfast, you can use iron and magnesium preparations at noon or afternoon.

The hypoglycemic effect of insulin or oral diabetes treatments may be enhanced if taken at the same time. Therefore, it is necessary to monitor blood sugar closely, especially in the early stages of ALA treatment. In separate cases, insulin or oral diabetes treatments may be reduced to prevent hypoglycemic manifestations.

Regular use of alcohol is a high risk agent that causes neurological diseases, so it can reduce the effect of Ubiheal 100. Therefore, patients with neuropathy diabetes should recommend avoiding alcohol even when not treated.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ºC.

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