Ubiheal 200 Nam Ha medicine treats sensory disorders due to diabetes neuropathy (5 blisters x 6 tablets)

Dosage form Box of 5 blisters x 6 tablets
Specifications Alpha Lipoic Acid

Ingredient

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Composition information	Content
Alpha Lipoic Acid	200mg

Uses

Indications

Ubiheal 200 drugs are indicated in cases of treatment of sensory disorders caused by diabetes.

Pharmacokological

Alpha Lipoic Acid (ALA) is an active ingredient active as a COFACROR of complexes: Pyruvate - Dehydrogesae; Alpha - ketoglutarate - dehydrogenase; Amino acid dehydrogenSae. Patients with cirrhosis, diabetes, atherosclerosis, neuritis often have a significant decline in this substance. During the metabolism, Thioctic acid will turn the form from oxidation (with a disulfid bridge in the molecule) to a reducing form with two free SH groups. Both forms are extremely powerful. They protect cells from free radicals formed during intermediate metabolism or the decomposition of external substances or from heavy metals. Dihydripic acid (dihydripic acid) also has the effect of cleaning the radicals of Superoxid, Hydroxyl and preventing lipid peroxid.

Anti -hyperglycemic effect:

Alpha Lipoic Acid acts in the insulin instrument that increases glucose consumption efficiency. On animals, alpha lipoic acid shows the ability to reduce blood glucose, increase the process of glycogen synthesis in the liver, and on the body, reduce the concentration of pyruvic acid in serum. However, the alpha lipoic acid mechanism helps cells increase the absorption of glucose. Alpha lipoic acid and dihydripoic acidic abdominal injections do not see significant effects on rabbit blood glucose, but significantly lower blood sugar with diabetes mice caused by alloxan. Dihydripoic acid also increases the synthesis of lipids in the liver from glycogen and acetate in diabetes.

Neurological protection effects:

Neuro-2A cells will produce axon when exposed to alpha lipoic acid shows that this substance is effective in the treatment of diabetes in humans.

Alpha Lipoic Acid when used orally has the effect of delaying the complications of the mice caused by Hexacarbon.

Animal studies also show that Dihydrolipoate protects Neuron from lesions of ischemia by preventing the accumulation of free oxygen roots in the brain tissue.

Alpha Lipoic Acid also has the effect of protecting the integrity of the nerve cell membrane in the mouse when causing peripheral nerve damage by acrylamid.

Pharmacokinetic

absorption

ALA is quickly absorbed after drinking. Absolute bioavailability when using orally reaches 20% compared to intravenously.

Distribution

Because the drug is quickly distributed into tissues, ALA's plasma is sold in humans for about 25 minutes.

ALA's relative bioavailability when using oral tablet is more than 60% compared to oral solution. The plasma concentration is measured about 4 µg/ ml after 0.5 hours after taking 600 mg of ALA.

Using the method of marking radiation bronze in animal experiments (mice, dogs) shows 80 - 90% of the drug is excreted in the form of metabolites in the kidneys. For people who only find a small amount of unused substances in the urine. Biological changes occur mainly due to oxidation of short chain (beta oxidation) and/ or methylation processes of corresponding thiol substances.

Before taking Ubiheal 200 Nam Ha medicine treats sensory disorders due to diabetes neuropathy (5 blisters x 6 tablets)

How to use

Ubiheal 200 capsules should take whole tablets with a sufficient amount of water when hungry. Food can reduce the absorption of the drug if used simultaneously. Therefore, patients need to keep the abdomen when taking the drug and the right time to take the drug is 30 minutes before meals.

Dosage

Daily dose of adults: Take 1-3 times, 1 Ubiheal 200 tablet, take about 30 minutes before eating.

No research in children and adolescents, do not use Ubiheal 200 with these objects.

In the case of serious sensory disorders, the injection therapy with alpha lipoic acid can be conducted first.

Due to diabetic neuropathy is a chronic disease, long -term treatment may be required. The basic foundation of diabetic neuropathy is the optimal blood sugar control.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

After intentionally and inadvertently drink large amounts of 10 g to 40 g to 40 g of acid with alcohol, severe poisoning and sometimes deadly cause. Signs of clinical poisoning can be first manifested in mental disorders or consciousness disorders, typically developing general seizures and lactic acid infections. In addition, reducing blood glucose, shock, globulin muscle melting blood, scattered thrombosis (dic), bone marrow weakening and multi -organ failure are described as a result of high doses of high doses.

Treatment opinions in case of overdose:

In case of suspicion of severe poisoning caused by Thioctic Acid (such as a dosage> 60 tablets 100 mg in adults and> 50 mg/ kg of weight in children) immediately takes patients to medical authorities with basic emergency conditions of poisoning cases (such as vomiting, gastric wash, activated carbon use ...). Treatment of general seizures, lactic acid infections and other life -threatening consequences of toxicity need to be awake with modern supporting care principles and need symptomatic treatment. The benefits of hemorrhage and peritoneal fertilizer or filtering methods to eliminate examsoctic acid do not give sure.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Ubiheal 200, you may experience unwanted effects (ADR).

Rarely 1/10000 ≤ ADR

Gastrointestinal disorders: Nausea, vomiting, stomach pain, bowel pain and diarrhea.

Hypersensitivity reactions: allergic reactions such as rash, urticaria and itching.

neurological diseases: Change and taste disorders.

General disorders: Because sugar metabolism can be improved in diabetes patients, hypoglycemia may occur. There have been reports on symptoms such as dizziness, dizziness, sweating, headache and visual disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ubiheal 200 drugs are contraindicated in cases of sensitivity to any ingredients of the drug.

Precautions when using

Patients with diabetes and glucose intolerance should be cautious when using ALA because ALA can reduce blood sugar. Blood sugar should be checked and adjust the dose of diabetes necessary to avoid blood glucose.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There is no data on the use of drugs in pregnant women, only drugs should only be used if the benefits are superior to the risk.

Pregnant women should treat with thioctic acid only when they have followed in accordance with the instructions of the physician, even if the toxicity studies with the reproductive system do not indicate any results that affect fertility and embryo development and no signs that cause toxicity to the fetus.

Breastfeeding period

Women who breastfeed should be treated with thioctic acid only when they have followed in accordance with the instructions of the physician, even if the toxic studies with the reproductive system do not give any effect on fertility.

There is no case of examinations that can go into breast milk.

Medicine interaction

Cisplatin's loss of activity when taking drugs with alpha lipoic acid. Alpha Lipoic Acid has the ability to create metal complexes, so it should not be used simultaneously with metal compounds (such as iron -containing preparations, magnesium -containing preparations, dairy products due to calcium containing calcium). If alpha lipoic acid during the day is taken 30 minutes before breakfast, you can use iron and magnesium preparations at noon or afternoon.

The hypoglycemic effect of insulin or oral diabetes treatments may be enhanced if taken at the same time. Therefore, it is necessary to monitor blood sugar closely, especially in the early stages of ALA treatment. In separate cases, insulin or oral diabetes treatments may be reduced to prevent hypoglycemic manifestations.

Regular use of alcohol is a high risk agent that causes neurological diseases, so it can reduce the effect of Ubiheal 200. Therefore, patients with diabetes should be recommended to avoid alcohol even when not treated.

Storage

In a dry place, avoid light, the temperature does not exceed 30ºC.

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