Ubiheal 300 Nam Ha medicine for diabetes and multiple neural disease (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Thioctic acid

Ingredient

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Composition information	Content
Thioctic acid	300mg

Uses

indications

Ubiheal drugs are indicated in the following cases:

Treatment of sensory disorders caused by diabetic neuropathy. Amino acid dehydrogenase. Patients with cirrhosis, diabetes, atherosclerosis and neuritis often have a significant decline in this substance. During the metabolism, Thioctic acid will turn from oxidation (with Disulfid bridge) to a reducing form with two free SH groups. Both forms are strong against toxicity. They protect cells from free radicals formed during intermediate metabolism, decomposition of exodes or from heavy metals. Dihydripoic acid (dihydripoic) also works to clean up superoxid, hydroxyl and prevent lipid peroxid.

Anti -hyperglycemic effect:

Acids of thioctic effects with insulin increase glucose consumption efficiency. In vivo, thioctic acid shows the ability to reduce blood glucose, increase the process of glycogen synthesis in the liver, and on the body, it reduces the concentration of pyruvic acid in serum. However, the acid mechanism helps cells increase the ability to absorb glucose unknown. Expressed abdominal injection of acidic acid and dihydripoic acid does not see significant effects on blood glucose in rabbits, but make significant blood sugar glucose in diabetes mice. Dihydripoic acid also increases the synthesis of lipids in the liver from glycogen and acetate in diabetes.

Neurological protection effects:

Neuro - 2A cells will produce axon when exposed to thioctic acid, showing that this substance is effective in the treatment of diabetes in humans.

Acids of thioctic when used orally has the effect of delaying the complications of the mice.

In Vivo studies also show that Dihydrolipoate protects Neuron from ischemic lesions by preventing the accumulation of free oxygen roots in the brain tissue.

Acids of Thioctic also protects the integrity of the nerve cell membrane on the mouse when causing peripheral nerve damage.

Dynamic pharmacokinetics

Acids are absorbed quickly after drinking. The acid of thioctic is initially metabolized in the liver. Absolute bioavailability when using orally reaches 20% compared to intravenously. Because the drug is quickly distributed into tissues, the semi -discharged time in the plasma of Thioctic acid in humans is about 25 minutes.

The relative bioavailability of thioctic acid when using oral tablet is more than 60% of the oral solution. The peak concentration of plasma is about 4 μg/ml after 0.5 hours oral 600 mg of thioctic acid.

in vivo, 80 - 90% of the drug is excreted in the form of metabolites in the kidneys. In humans, there is only a small amount of intact drugs found in the urine. The biological change occurs mainly due to the short -cut oxidation (β - oxidation) and/or S - methylation of isotope.

Before taking Ubiheal 300 Nam Ha medicine for diabetes and multiple neural disease (3 blisters x 10 tablets)

How to use

oral medication, drinking whole tablets with enough water before eating about 30 minutes (when hungry)

Dosage

The dose is often used for adults: 1 tablet/time x 1-3 times/day.

In case of serious sensory disorders, the infusion therapy can be conducted first.

Due to diabetic diameter is a chronic disease, long -term treatment can be required, the basic foundation of diabetic neuropathy is the optimal blood sugar control.

There is no research in children and adolescents, not using Ubiheal 300 with these objects.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

After drinking a large amount of 10 - 40 g of acid with alcohol, severe poisoning and sometimes deadly cause. Signs of clinical poisoning can be first manifested in mental disorders or consciousness disorders, typically the development of general seizures and lactic acid infections. In addition, reducing blood glucose, shock, and globulin globulin, scattered blood thrombosis (dic), bone marrow weakness and multi -organs are described when taking high doses of high -dose acid.

Handling: In case of suspicion of severe poisoning due to Thioctic Acid (taking the dose> 6g in adults and> 50 mg/kg in children), immediately take patients to health agencies with basic emergency conditions of cases of poisoning (causing vomiting, gastric wash, activated charcoal use ...).

Treatment of general seizures, lactic acid infections and other life -threatening consequences that need to be done with modern supporting care principles and need symptom treatment. Hemorrhage, peritoneal jurisdiction or filtering methods to eliminate examsoctic acid does not give sure results.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ubiheal, you may experience unwanted effects (ADR).

Very rare, ADR

Digestive: Nausea, vomiting, stomach - intestines, diarrhea.

skin: allergic reactions such as rash, urticaria, itching.

Nervous system: Change or taste disorders.

Because sugar metabolism can be improved in diabetes patients, hypoglycemia may occur. Symptoms similar to hypoglycemia have been described as dizziness, sweating, headache, visual change.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ubiheal drugs contraindicated in the following cases:

Hypersensitivity to ALA or any ingredients of the drug.

Be cautious when using

Patients with diabetes and glucose intolerance should be cautious when using ALA because ALA can reduce blood sugar. Blood glucose test and adjust the dose of diabetes needed to avoid blood glucose.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Products should only be used for pregnant and lactating women after careful consideration between benefits and risks.

Pregnant women only treated with thioctic acid when they have followed the doctor's instructions, even if the toxic studies have no results that affect fertility and embryo development and no signs show toxicity to the fetus.

The period of breastfeeding

It is unknown whether the acidCtic acid is through the placenta or whether or not the secretion in human milk or not. Breastfeeding women are only treated with thioctic acid when they have followed in accordance with the doctor's instructions.

Drug interactions

lose the effect of cisplatin when used simultaneously with Ubiheal. Thioctic acid has the ability to create complexes with metal so it should not be used simultaneously with metal compounds (iron, magnesium, dairy products containing calcium). If using Ubiheal 30 minutes before breakfast, the products containing iron, Magnesi can be used at noon or afternoon.

Hypoglycemic effects may occur when used in combination with insulin or other diabetes treatment drugs. Therefore, it is necessary to monitor blood sugar closely, especially in the early stages of therapy with thioctic acid. In special cases, reducing insulin dose or oral diabetes treatment drugs is necessary to prevent signs of hypoglycemia.

Regular use of alcohol is a high risk agent for the development and growth of neurological diseases, which can reduce the success of treatment with Ubiheal. Therefore, patients with diabetic neuropathy should be recommended to avoid alcohol. This also needs to propose for the time of untreated.

Storage

In a dry place, avoid light, temperature not exceeding 30 ° C.

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