Ucyrin 75mg lesvi medication reduces atherosclerosis events (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Clopidogrel

Ingredient

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Composition information	Content
Clopidogrel	75mg

Uses

Indications

Ucyrin 75 mg is indicated in the following cases:

Reduces events related to atherosclerosis (myocardial infarction, stroke, raw death of blood vessels) and patients with evidence of atherosclerosis such as a recent stroke, recent myocardial infarction or a diagnosed peripheral artery disease. Ticlopidine. Clopidogrel, as well as ticlopidine, is a strong platelet aggregation inhibitor caused by ADP. In Vivo, Clopidogrel helps protect against artery embolism. Moreover, Clopidogrel is used on dogs and monkeys to eliminate platelet aggregation, combining to slow down the flow on the coronary artery narrowed and have endothelial damage or on the femoral artery. In addition, Clopidogrel works faster and has higher safety data than Ticlopidine.

Clopidogrel is a pre -pharmaceutical, which needs biological metabolism through the liver into active substance, which is likely to be a derivative of Thiol, which has not been determined in plasma.

Platelet collection due to ADP and Thrombin is inhibited depending on the first dose orally orally at a healthy volunteer. The drug reduces the number of ADP function receptors that intermediate inhibits the stimulated adenyl cyclase.

pharmacokinetics

absorption - distribution

After drinking, Clopidogrel is quickly absorbed (not related to food or the use of antacids) and is under the initial metabolism in the liver. The peak concentration of plasma (3 mg/l) of the initial metabolic substance is reached about 1 hour after use of many doses of 75 mg/day.

Metabolism - Elimination

Circulation concentration in the plasma of the main metabolites increases proportional to clopidogrel doses of 50 - 150 mg. Clopidogrel and carboxylic acid derivatives are heavily connected to protein and are excreted the same through feces and urine. The sale time of carboxyl derivatives is about 8 hours.

Before taking Ucyrin 75mg lesvi medication reduces atherosclerosis events (2 blisters x 14 tablets)

How to use

oral medication, can be taken or not with the same meal

Dosage

Adults: The recommended dose is 75 mg/day/day

Patients with renal failure, elderly people: No dose adjustment.

Children: The safety and effectiveness of the drug have not been set on this object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

However, no side effects are recorded when using the single clopidogrel orally at a healthy volunteer. Bleeding time also lasts with a coefficient of 1.7 similar to the dose of 75 mg/day.

Can be transmitted when the urgently adjusted effects cause bleeding of clopidogrel.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ucyrin 75 mg, you may experience unwanted effects (ADR).

Clopidogrel has a lower frequency of causing gastrointestinal bleeding than aspirin, shown in the lower hospital number and lower stomach ulcers. The unwanted effects are different from the lower rate noted as rash, bleeding, itching, diarrhea, abdominal pain and indigestion.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ucyrin 75 mg is contraindicated in the following cases:

Patients with hypersensitivity to drugs or any ingredients of the drug

Patients with progressive bleeding disease: stomach ulcer, retinal hemorrhage, intracranial hemorrhage, severe liver failure or jaundice.

Caution when using

clopidogrel causes prolonged bleeding time. Although the frequency of gastrointestinal bleeding is lower than aspirin, drugs should not be tended to bleed (stomach ulcers). When used with clopidogrel with another drug that is likely to cause bleeding, it is necessary to have a strict medical monitoring after the risk is carefully evaluated.

Clopidogrel should be used cautiously in people with liver disease, patients at risk of increased bleeding after trauma, recent surgery or other pathological conditions.

For patients who have to undergo selective surgery, it is possible to consider stopping clopidogrel 7 days before surgery to degrees the impact. When urgent adjustment is needed, platelets can be reversed with the pharmacological effect of clopidogrel.

The ability to drive and operate machinery

unknown.

Pregnancy

Classification B pregnancy by FDA.

According to studies performed many times on rats and rabbits at a dose of 500 and 300 mg/kg/day (65 and 78 times daily doses for people calculated by Mg/m2), there is no evidence that clopidogrel reduces fetal or toxic ability to fetus.

However, so far there is no adequate and well -controlled research on pregnant women. Because animal studies can not always predict the response on humans, Clopidogrel is only for pregnant women when really necessary.

The period of breastfeeding

Experiments on mice shows clopidogrel and/or its metabolites are secreted in milk. It is not clear whether the drug is excreted through breast milk or not. Because there are many drugs secreted in breast milk and because there may be serious side effects on breastfeeding, so it is advisable to consider the importance of the drug for the mother and decide to stop breastfeeding or stop taking the drug.

Drug interaction

Do not detect clinical significant side effects in patients using many different drugs and at the same time such as diuretics, β blockers, enzyme inhibitors, calcium blockers, coronary dilatation, hypoglycemia, anti -epilepsy and replacement hormone therapy.

In vitro, high concentration Clopidogrel inhibit cytochrome P450 (CYP2C9) and therefore can affect the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin and nsAID drugs.

Storage

Store at temperatures below 30 ° C. Avoid light.

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