Unafen oral solution 100mg/5ml Gracure analgesic, anti -inflammatory, fever (100ml)

ibuprofen is a nonsteroidal anti -inflammatory drug, derivative of propionic acid, has a prostagladin synthesis effect. In humans, ibuprofen has anti -inflammatory, analgesic and antipyretic effects. In addition, ibuprofen also has anti -platelet gathering effect.

Dynamic pharmacokinetics

ibuprofen are quickly absorbed after drinking and distributed throughout the body. Peak concentration in plasma is achieved after 1-2 hours if used with food or about 45 minutes if not in the same food.

The drug is quickly excreted through the urine.

The sale time of the drug is about 2 hours.

The drug is metabolized into two non -active chemicals and eliminates very quickly through the urine. About 1% in constant form, 14% in the form of combined.

ibuprofen binds to plasma proteins.

Elderly: Elderly people are at risk of increasing serious consequences of adverse reactions. If it is necessary to use nonsteroidal anti -inflammatory drugs, the lowest dose should be used in the shortest possible time. Patients need to be monitored regularly on gastrointestinal bleeding while treating nonsteroidal anti -inflammatory drugs. If the kidney or liver function is weakened, the dose should be adjusted for each patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose:

Most patients who overdose nonsteroidal anti -inflammatory drugs will cause nausea, vomiting, epigastric pain or danger when causing diarrhea, tinnitus, headache and gastrointestinal bleeding can also occur.

Management:

Often symptomatic and supportive treatment includes many respiratory support measures and monitoring survival and heart indicators until stable. If the new patient is overdose within 1 hour, considering drinking activated carbon. If convulsions occur regularly or prolonged, Diazepam or Lorazepam should be treated. Use bronchodilators for asthma.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Be cautious when using

Heart thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient does not have previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, Ibuprofen is required at the lowest daily doses in the shortest possible time as possible.

The elderly may experience unwanted effects when using nonsteroidal anti -inflammatory drugs, especially such as hemorrhage and puncture of the digestive tract can be fatal.

Systemic lupus and mixed connective tissue disease - may increase the risk of aseptic meningitis.

Should avoid simultaneous use of ibuprofen with nonsteroidal anti-inflammatory drugs including Cycloxygenase-2 selective inhibitors.

There have been reports on gastrointestinal bleeding, ulcers or gastric perforation that can be fatal with all nonsteroidal anti -inflammatory drugs at any time during treatment, with or without warning symptoms or a history of serious gastrointestinal diseases.

Be cautious when used in patients being treated simultaneously with drugs that may increase the risk of poisoning or gastric bleeding, such as corticosteroids or anticoagulants such as wafarin, selective regression inhibitors serotonin, platelet aggregation inhibitors such as aspirin.

Be cautious when used in patients with bronchial or allergies because patients who use nonsteroidal anti -inflammatory drugs - may have sensitive asthma combined with severe bronchospasm.

Heart, kidney and liver failure:

The use of nonsteroidal anti -inflammatory drugs may cause prostaglandin biosynthesis depending on the dose. The regular use of other similar painkillers increases this risk. Patients with the highest risk are those with impaired renal function, heart failure, liver dysfunction, diuretic users and the elderly. For these patients, it is necessary to use the lowest doses effectively, in the shortest possible time and monitor the kidney function, especially in prolonged patients.

Be careful when taking medication for patients with a history of heart failure or hypertension because edema has been reported to be related to the use of ibuprofen.

Effects to the skin:

Serious reactions on the skin, some deaths, including flaking dermatitis, Steven-Johnson syndrome and poisoned epidermal necrosis.

Do not use drugs for children from 3 to 6 months old too 24 hours.

Do not take medicine for children> 6 months old too 3 days.

Contact the doctor immediately if the symptoms are prolonged or worse.

Do not exceed the allowed dose.

Not recommended for children under 3 months of age.

The drug containing aspartame can turn into phenylalanine in the body that affects people with urinary phenylketon.

The medication contains Sunset Yellow can cause allergies, so be cautious when taking this drug.

The drug contains sorbitol, so the patient has rare genetic problems that do not tolerate fructose should not use this drug.

The drug contains sodium methyl hydroxybenzoate, sodium propyl hydroxybenzoate can cause allergies, so be careful when taking this medication.

The effect of the drug on the ability to drive and operate machinery

Unwanted effects such as dizziness, drowsiness, fatigue and visual disorders may occur after using nonsteroidal anti -inflammatory drugs. If you encounter these unwanted effects, patients should not drive or operate machinery.

Use drugs for women during pregnancy and lactation

pregnancy:

Although there is no report on the possibility of teratogenicity on experimental animals, Ibuprofen should be avoided in the first 6 months of pregnancy.

breastfeeding period:

ibuprofen is very small in breast milk and does not seem to affect babies.

Drug interaction

should avoid using ibuprofen while using the following drugs:

Aspirin: Due to an increase in unwanted effects, unless using low -dose aspirin (no more than 75 mg per day) under a doctor's guidance.

Other nonsteroidal anti-inflammatory drugs include selective inhibitors Cycloxygenase-2: Should avoid using 2 or more nonsteroidal anti-inflammatory drugs because it can increase unwanted effects.

should be careful to use ibuprofen simultaneously with the following drugs:

Anticoagulant: nonsteroidal anti -inflammatory drugs can increase the effects of anticoagulants, such as warfarin.

Anti -blood pressure and diuretics: nonsteroidal anti -inflammatory drugs can reduce the effects of these drugs. Diuretics may increase the risk of kidneys to the kidneys of nonsteroidal anti -inflammatory drugs when used simultaneously.

Concentrated with corticosteroids increases the risk of ulcer and gastric hemorrhage

Anti -plateletic drugs and selective recovery inhibitors serotonin increases the risk of stomach bleeding if used simultaneously.

Concentrated with cardiac glycosides with nonsteroidal anti -inflammatory drugs can worsen heart failure, reduce glomerular filtration and increase serum glycosides.

ciclosporin: may increase the risk of toxicity to the kidneys of nonsteroidal anti -inflammatory drugs when used simultaneously.

Mifepristone: Do not use nonsteroidal anti -inflammatory drugs after 8-12 days of using Mifepristone because it can reduce the effect of Mifepristone.

tacrolimus: may increase the risk of kidney toxicity when used simultaneously with nonsteroidal anti -inflammatory drugs.

Zidovudine: Increased risk of blood poisoning when used simultaneously with nonsteroidal anti -inflammatory drugs. There is evidence of increased risk of joint hematoma and hemorrhoids in positive HIV patients, the risk of bleeding when using simultaneously zidovudine and ibuprofen.

Quinolone antibiotics: Animal data indicates that nonsteroidal anti -inflammatory drugs may increase the risk of convulsions related to Quinolone antibiotics. Patients taking nonsteroidal anti -inflammatory drugs simultaneously with Quinolone may increase the risk of seizures