Ursodiol c 250mg pharmascism to treat cholestasis cirrhosis, melt gallstones (30 tablets)

Dosage form Box of 30 tablets
Specifications Ursodeoxycholic Acid

Ingredient

Composition information	Content
Ursodeoxycholic Acid	250mg

Uses

Indications

The drug is prescribed to treat cirrhosis primary bile stasis (PBC) and dissolve the radiotherapy radiation in patients with gallbladder operating.

Pharmacokological

Ursodiol is a secondary bile acid (secondary) that is produced from intestinal bacteria, while primary bile acids are produced from the liver and accumulated in the gallbladder. When excreted into the colon, primary bile acids can be converted into secondary bile acids by intestinal bacteria strains. Primary and secondary bile acids help the body digest lipids.

Ursodiol has the activity that regulates the balance between the components of the bile (reduces the synthesis of cholesterol in the bile), stimulates and helps regenerate liver cells, creating favorable conditions to dissolve cholesterol stones.

Although Ursodiol is not a derivative of animals, it has been found in large quantities in bear bile.

Ursodiol has the effect of promoting the absorption and esterification of vitamins B1 and B2.

pharmacokinetic

absorption:

Ursodiol is quickly absorbed.

Distribution:

After taking 96 - 98% is connected to plasma proteins and is transferred directly to the liver, only a small amount of circulation in the circulation.

Metabolism:

Ursodiol quickly absorbed into the liver and binded to glycin or taurin and then discharged into the bile. A small percentage Ursodiol is subject to metabolism in the liver - intestinal cycle.

Era:

Ursodiol eliminates through breast milk, kidneys, and mainly through stool.

Before taking Ursodiol c 250mg pharmascism to treat cholestasis cirrhosis, melt gallstones (30 tablets)

How to use

Take oral use.

Dosage

oral 13 - 16 mg/kg body weight/day, divided into 2 times, along with food or milk in the morning and evening. The daily dose may be unevenly divided and the larger dose given before bedtime to neutralize the increase in bile cholesterol levels overnight.

Take the initial dose of 250 mg, twice a day in 2 weeks of treatment, then increase by 250 mg/day to the recommended dose or reach the maximum dose.

If diarrhea appears while increasing the dose or at the end of the treatment period, adjusting the dose until the diarrhea is gone, then the old dose is usually tolerated.

Patients with fat (weight) may need a dose of 20 mg/kg body weight/day.

Unprecedented doses for children.

Note: Depending on the size and composition of gallstones with cholesterol, may require treatment that lasts 3 months to 2 years. Every 3 to 9 months, X-ray of gallbladder or ultrasound to monitor the response to the drug. The treatment may take 2 years, depending on the size of the stones. Should continue treatment for about 3 months after X-rays are no longer gravel.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, liver function should be monitored. If necessary, ion exchange resin can be used to combine with bile acids in the intestine.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ursodiol c 250 mg , you may experience unwanted effects (ADR).

Rare, 1/10000

Digestive: diarrhea .

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ursodiol c 250 mg Contraindications in the following cases:

Melt non -penetrating gallstones and should not be used in patients with non -working gallbladder.

Precautions when used

A product of this group has been found to cause cancer in animals. The involvement of these findings to use PMS-Rasodiol C in the clinical clinical has not been established.

The ability to drive and operate machinery

does not affect the ability to control the train and operate machinery.

Pregnancy

Do not take medicine for pregnant or suspected pregnancy.

Breastfeeding period

Do not use for breastfeeding people.

Drug interaction

Some drugs, such as cholestyramine , Charcoal, Colespol and some antacids (such as hydroxide aluminum) in combination with bile acids in vitro. Therefore, they may have the same effect in Vivo and may interfere with Ursodiol's absorption.

Medications that increase cholesterol elimination in bile, such as estrogen hormones, oral contraceptives rich in estrogen and some drugs that reduce blood cholesterol, such as clofibrat, should not be used with Ursodiol C 250 mg.

ursodiol can increase the absorption of cyclosporin in transplant patients.

Storage

Store in a dry place at 30 ° C.

To be out of reach of children.

Read the user manual carefully before use.

If you need more information, please consult a doctor.

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