Ursodiol c 500mg pharmascascionation to treat cholestasis cirrhosis, melt gallstones (100 tablets)

Dosage form Box of 100 capsules
Specifications Ursodeoxycholic Acid

Ingredient

Composition information	Content
Ursodeoxycholic Acid	500mg

Uses

indications

Treatment cirrhosis Molecular stasis (PBC) and dissolve the radiation of the gallstones in patients with gallbladder operating.

Pharmacokology

ursodiol is a secondary bile acid (secondary) produced from intestinal bacteria, while primary bile acids are produced from the liver and accumulated in the gallbladder. When excreted into the colon, primary bile acids can be converted into secondary bile acids by intestinal bacteria strains.

Primary and secondary bile acids help the body digest lipids. Ursodiol has an activity that regulates the balance between the components of bile (reduces cholesterol synthesis in bile), stimulates and helps regenerate liver cells, creating favorable conditions to dissolve cholesterol stones.

Although Ursodiol is not a derivative of animals produced from animals, it has been found in large quantities in bear bile. Ursodiol has the effect of promoting the absorption and esterification of vitamins B1 and B2.

pharmacokinetics

absorption:

Ursodiol is quickly absorbed.

Distribution:

After taking 96-98% is connected to plasma proteins and is transferred directly to the liver, only a small amount of circulation within the circulation.

Metabolism:

Ursodiol quickly absorbed into the liver and binded to glycin or taurin and then discharged into the bile. A small ratio of Ursodiol is subject to metabolism in the liver cycle.

Era:

Ursodiol eliminates through breast milk, kidneys, and mainly through stool.

Before taking Ursodiol c 500mg pharmascascionation to treat cholestasis cirrhosis, melt gallstones (100 tablets)

How to use

Take oral use.

Dosage

Tap:

13-16 mg/kg body weight/day, divided into 2 times, along with food or milk in the morning and evening.

Daily dose can be divided irregularly and larger dose given before bedtime to neutralize the increase in bile cholesterol levels overnight.

Take the initial dose of 250 mg, twice a day in 2 weeks of treatment, then increase by 250 mg/day to the recommended dose or reach the maximum dose.

If diarrhea appears while increasing the dose or the end of the treatment period, adjusting the dose until the diarrhea is gone, then the old dose is usually tolerated. Patients with fat (weight) may need a dose of 20 mg/kg body weight/day.

Note: Depending on the size and composition of gallstones with cholesterol, may require treatment that lasts 3 months to 2 years. Every 3 to 9 months, X-ray gallbladder or ultrasound to monitor the response to the drug. The treatment may take 2 years, depending on the size of the stones. Should continue treatment for about 3 months after X-rays are no longer gravel.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? However, liver function should be monitored. If necessary, ion exchange resin can be used to combine with bile acids in the intestine.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using PMS-RSodiol c , you may experience unwanted effects (ADR).

Rare, ADR

Digestive: diarrhea

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

PMS-RSodiol c is not suitable for dissolving non-radiological gallstones and should not be used in patients with non-working gallbladder.

Be cautious when using

A product of this group has been found to cause cancer in animals. The involvement of these findings to use PMS-Rasodiol C in the clinical clinical has not been established.

The ability to drive and operate machinery

PMS-RSodiol C does not affect the ability to control the train and operate machinery.

Pregnancy

Do not take medication for pregnant or suspected pregnancy.

Breastfeeding period

Not used for breastfeeding people.

Interactive drug

Some drugs, such as cholestyramine , Charcoal, Colespol and some antacids (such as hydroxide aluminum) in combination with bile acids in in vitro. Therefore, they may have the same effect in Vivo and may interfere with Ursodiol's absorption.

Medications that increase cholesterol elimination in bile, such as estrogen hormones, oral contraceptives rich in estrogen and some drugs that reduce blood cholesterol, such as clofibrat, should not be used with PMS-Rosodiol c.

ursodiol can increase the absorption of cyclosporin in transplant patients.

Storage

Store in a dry place at a temperature of less than 30 ° C.

Other drugs

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