Ursoliv 250 mega We Care medicine to treat gallstones (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Ursodeoxycholic Acid

Ingredient

Composition informationContent
Ursodeoxycholic Acid250mg

Uses

indications

Ursoliv 250 drug is indicated in the following cases:

  • Làm tan sỏi mật ở bệnh nhân bị sỏi cản quang túi mật không bị vôi hóa có đường kính nhỏ hơn 20 mm không bắt buộc phẫu thuật cắt bỏ túi mật hoặc bệnh nhân có nguy cơ cao khi phẫu thuật như người cao tuổi, phản ứng khi gây mê toàn thân, hay bệnh nhân từ chối phẫu thuật.
  • Ngăn ngừa sự hình thành sỏi mật ở bệnh nhân bị béo phì và đang giảm cân nhanh.
  • Cải thiện chức năng gan trong xơ gan nguyên phát.
  • Bệnh gan ứ mật.

    • Dược lực học

    Cơ chế ngăn chặn sự hình thành sỏi mật của acid ursodeoxycholic chưa được xác định rõ, có thể cho rằng khi sử dụng dưới dạng uống thì acid ursodeoxycholic tập trung ở mật sẽ làm giảm độ bão hòa cholesterol trong ống mật thông qua sự ức chế hấp thu cholesterol ở ruột. The reduction of cholesterol saturation leads to gradually dissolving cholesterol in gallstones.

    Ursodeoxycholic acid increases the circulation of the bile duct. Trong bệnh gan ứ mật mãn tính, sự hiện diện acid ursodeoxycholic làm giảm tính bào mòn của muối mật, vì vậy làm giảm độ độc tế bào của chúng. Acid ursodeoxycholic cũng có thể bảo vệ tế bào gan khỏi tác hại của các acid mật độc hại như lithocholat, deoxycholat, và chenodeoxycholat trên bệnh nhân bị bệnh gan mãn tính.

    Dynamic pharmacokinetics

    Ursodeoxycholic acid is mainly absorbed from the small intestine (about 90% of the dose). Ursodeoxycholic acid is strongly connected to plasma proteins.

    First metabolism through the liver, external ursodexolic acid is metabolized through the liver as taurin and conjugated glycin. These complexes are excreted on the bile. Time to reach the peak concentration from 1 - 3 hours.

    Semi -selling time of ursodeoxycholic acid from 3.5 to 5.8 days. Ursodeoxycholic acid is eliminated mainly in feces, a very small amount excreted through the urine.

    Small amount of Ursodeoxycholic acid does not absorb entry into the large intestine and decomposed by bacteria into 7 - dehydroxylation, resulting in a part of lithocholic acid absorbed into the large intestine but sulfate in the liver and is quickly excreted in feces in the form of sulfolitholyl glycin or combination of sulfolithochylyl lurin.

    Before taking Ursoliv 250 mega We Care medicine to treat gallstones (5 blisters x 10 tablets)

    How to use

    oral medication.

    Dosage

    Melt gallstones

    Dosage for recommendations 8 - 10 mg/kg/day (divided into 2-3 times, drink at meals). Treatment period is from 6 to 12 months. After the gravel has dissolved, it is recommended to continue using at least 3 months to accelerate the dissolution of small elements.

    Preventing the formation of gallstones

    Dosage recommended in patients with obesity and are losing weight fast is 800 mg x 2 times/day, drinking at meals.

    Cholestock liver disease

    Use 13 - 15 mg/kg/day, divided into 2 times, used in meals.

    primary cirrhosis

    Use 10 - 15 mg kg/day, divided by weight as follows:

    weight Dosage
    Morning 1
    - 1
    1 2 Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Ursoliv 250, you may experience unwanted effects (ADR).

    Side effects can occur such as allergies, cholecystitis, leukemia, stomach ulcers, urinary tract infections.

    Unwanted digestive effects can occur as diarrhea.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Ursoliv 250 contraindications in the following cases:

  • Sensitive to any ingredients of the drug.

    • People allergic to bile acid.

  • Patients with complications of gallstones such as stomach - duodenal ulcer, bile duct obstruction, cholecystitis, cholecystitis, pancreatitis or gallstones caused by gallstones.
  • Patients with calcium stones.

    • Be cautious when using

    in patients with liver test

    Patients using Ursodeoxycholic acid should measure SGPT (ALT), SGOT (AST), GGT, ALP and Bilirubin at the time before and after the therapy to be able to propose the right treatment regimen. Monitor the serum index as soon as the treatment is started, after 1 month to the first 3 months (depending on the doctor's instructions), and after every 6 months throughout the treatment process. Ursodeoxycholic acid should be stopped when liver enzyme indicators.

    Use for children

    Safety and efficiency have not been proven.

    The ability to drive and operate machinery

    unknown effects of drugs on driving and operating machinery.

    Pregnancy

    Do not take medication for pregnant or suspected pregnancy.

    breastfeeding period

    Not used for nursing people. So far, no research documents have concluded on this issue.

    Drug interaction

    Concentrated use with antacids such as Aluminum, Cholestyramin, Colestipol, Blood Lipid Hypademins, especially Clofibrat, Estrogen, Neomycin, Oral contraceptive or progestin will reduce the absorption and effects of Ursodeoxycholic acid.

    Storage

    In a dry place, avoid light, temperature below 30 ° C.

    Other drugs

    Disclaimer

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