Utrogestan 200mg Besins drugs supplement hormones in gynecological diseases (15 tablets)

Dosage form Box of 15 tablets
Specifications Progesterone

Ingredient

Composition information	Content
Progesterone	200mg

Uses

Indications

Utrogestan 200mg drugs are indicated in the following cases:

Gynecological treatment

Disorders related to progesterone deficit, such as premenstrual syndrome, irregular menstruation due to ovulation disorders or no ovulation, benign breast disease, premenopause. Egg).

threaten miscarriage or a consecutive miscarriage due to impairment. Progesterone.

pharmacokinetic

Progesterone concentration increases in the first hour and reaches the highest plasma peak concentration after 1 to 3 hours of use.

Oral: If calculating the time of storing hormones in tissue, it is necessary to divide the dose to 2 times apart about 12 hours apart to maintain the drug concentration effective 24 hours a day.

Vaginal lines: In the recommended dose, the plasma progesterone levels are stable and maintained, equivalent to the progesterone level in the phase of a normal menstrual ovulation cycle.

Utrogestan 200mg using vaginal tract growth of the endometrium so it is suitable for embryo nesting.

When increasing to a higher dose, vaginal drugs can give progesterone levels in the blood equivalent to the concentration described in the first 3 months of pregnancy.

Metabolism: Metabolic substances in plasma and urine are like substances secreted in the physical phase. The main metabolites in plasma are 20-α-tydroxy-Δ-4-4-Pregenolon and 5-α-dihydroprogesterone.

Elimination: 95 % of the drug is discharged in urine in the form of conjugated glycuronid metabolites. The main metabolites in urine are 3-α-5-β-Preceganediol (Pregnandiol).

Before taking Utrogestan 200mg Besins drugs supplement hormones in gynecological diseases (15 tablets)

How to use

Utrogestan 200mg drug used orally or vaginal.

Dosage

Oral

The average dose is from 200 - 300 mg of progesterone daily divided into 1 to 2 times, that is, use 200 mg in the evening before going to bed and 100 mg in the morning if needed.

In mental impairment (Menstrual syndrome, benign breast disease, irregular menstrual period, premenopause): 10 -day treatment per cycle from 17 to 26 days. Drugs.The average dose is 200 mg of progesterone per day (1 tablet of 200 mg or 2 tablets of 100 mg divided into 2 times, 1 tablet in the morning and 1 tablet in the evening), placed deep into the vagina. This dose may increase depending on the response of each patient.

In case of a partial deficiency (ovulation disorders, irregular menstruation): 200 mg of progesterone per day, 10 days for each cycle, usually starting from the 17th to the 26th day. Day 15 to the 25th day of the cycle. From the 26th day and in the case of pregnancy, increase the dose to 100 mg of progesterone/day per week to finally reach a maximum dose of 600 mg of progesterone/day divided into 3 times. Maintain this dose until the 60th day. period.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? With orally, unwanted effects recorded above are most overdose symptoms. In the case of reducing the dose, the symptoms will automatically go away. In some patients, the usual dosage may be too high, with evidence that endogenous progesterone concentrations are secreted continuously or batches without being controlled, manifested by sensitivity to the drug or accompanied by low blood oestradiol levels. The following tips for patients:

Dosage reduction or progesterone in the evening before going to bed, 10 days in a cycle in case of drowsiness or fleeting dizziness. Test to ensure enough oestradiol levels in the blood. However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using UTROGESTAN 200mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Reproductive system: Change menstrual cycle, loss of menstruation, bleeding between menstrual cycle.

Systemic: headache.

Systemic body: Drowsiness, fleeting dizziness.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Utrogestan 200mg drug contraindicated in the following cases:

Severe liver failure.

Be cautious when using

under the recommended conditions, this treatment is not contraceptive.

The menstrual cycle may be short or bleeding if the treatment starts too early, especially before the 15th of the cycle.

In the case of uterine bleeding, Utrogestan 200mg is not used until the cause is determined, as by the endometrial examination.

Due to the inability to completely eliminate the risk of blood tyrant and metabolic thrombosis, it should be discontinued in the following cases:

Eye disorders such as vision loss, double vision, retinal vascular damage.

Should closely check in patients with a history of thrombosis.

In case of sudden menstruation, it must be certain that there is no pregnancy.

More than half of the cases of early spontaneous miscarriage due to genetic complications. Moreover, infections or mechanical disorders may have a miscarriage and premature birth. In these cases, progesterone only works to slow down dead eggs. Therefore, using progesterone should only be for cases where the royal secretion is not enough.

The ability to drive and operate machinery

Attention in the driver or using machines, this drug can cause drowsiness and/or dizziness when used oral. To avoid this side effect should take the drug in the evening.

Pregnancy

There is no contraindication when using Utrogestan 200mg during pregnancy even in the first weeks of pregnancy.

Breastfeeding period

No specific research Progesterone has passed through breast milk, so avoid taking medicine for nursing women.

Medicinal interaction

used in combination with other drugs can affect the metabolism of progesterone, which can change the effectiveness of the drug such as:

Strong enzyme induction drugs such as barbiturate, anti -epileptic drugs (phenyltoin), rifampicin, phenylbutazon, spironolacton and griseofulvin: these drugs increase the metabolism in the liver. Steroid.

Because these interactions may vary depending on the individual, clinical results cannot be predicted.

Progestin can reduce glucose absorption, so patients with diabetes will increase insulin demand and other diabetes treatments.

Storage

Do not leave at hand and children's vision.

Do not use expired drugs stated on blisters and boxes.

Store at temperatures below 30 ° C.

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