Uvomo Saga treats digestive disorders (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Mosaprid citrate

Ingredient

Composition information	Content
Mosaprid citrate	5mg

Uses

indications

Uvomo drugs are indicated in the following cases:

Gastrointestinal disorders associated with gastric movement such as heartburn, nausea, vomiting. A selective 5-HT4 receptor owner. This complex makes it easy or restoring gastric gastric motion. The effect of mosaprid is to increase acetylcholin release and stimulate the gastrointestinal movement.

Pharmacokinetics

absorption

After drinking, Mosaprid is completely absorbed in the digestive organs. Studies in the report that after taking single doses of Mosaprid in healthy people, the average plasma concentration of Mosaprid reaches the peak after 0.5 - 1 hour.

Food effects: Mosaprid can be taken before or after eating.

Distribution

mosaprid binds to protein in plasma 99%.

Metabolism

Mosaprid is mainly metabolized in the liver because the P-450 enzyme is mainly CYP3A4. The main metabolites are des-fluorobenzyl complexes.

Excretion

Mosaprid is excreted in urine and feces. Has been reported after taking the single dose of Mosaprid Citrate 5 mg in healthy people when hungry. 0.1 % is excreted in a constant form while 7 % is excreted in the form of main metabolites. The apparent selling time is 1.4 - 2 hours.

Before taking Uvomo Saga treats digestive disorders (10 blisters x 10 tablets)

How to use and dose

oral 5 mg/time x 3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Should be treated by gastric lavage and/or using activated carbon, careful monitoring and supportive treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Uvomo, you may experience unwanted effects (ADR).

Unknown frequency, ADR

Digestive: diarrhea, abdominal pain, constipation, dry mouth, nausea/vomiting, change taste, bloating, numbness.

nerve: dizziness, headache, insomnia.

Systemic: edema, rash, urticaria.

Blood and hematopoietic system: hypernephastically increased, leukopenia. liver - bile: increase liver enzyme activity. Cardiovascular: Brushing the chest.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Uvomo drugs contraindicated in the following cases:

Patients who are hypersensitive to mosaprid or any ingredients of the drug.

Patients with severe liver failure.

Gastrointestinal bleeding, digestive mechanical blockage.

Perforated gastrointestinal tract or cases of danger when stimulating the gastrointestinal movement.

Be cautious when using

Continue to use the drug is not recommended if not improved gastric symptoms after 2 weeks of taking the drug.

Elderly, kidney failure, liver failure.

The ability to drive and operate machinery

should be used cautiously.

pregnancy

There are no Mosaprid studies well controlled during pregnancy. The safety of mosaprid in pregnant women has not been established. Mosaprid should be used only when the benefits are more likely to be possible.

The period of breastfeeding

There are no mosaprid studies well controlled while breastfeeding. Data from animal studies shows that mosaprid is excreted through breast milk. Using drugs in breastfeeding women should avoid. Mosaprid should be used only when the benefits of treatment are more likely to occur in breastfeeding women. Women who are breastfeeding should stop drugs during Mosaprid treatment.

Drug interaction

Mosaprid concentration increased by erythromycin.

mosaprid may increase the risk of extending the QT about QT when using simultaneously with the drug that extends the QT range such as anti -arrhythmic drugs (amiodaron, flecainid, process ...), psychotic drugs (chlorpromazin, haloperidol, olanzapin ...), three -round anti -depression drugs (amitreptylin, clomidpramin ...), terfenadine, terfenadin, terfenadine) Astemizol, Quinin (Mefloquin, Chloroquin), Macrolid antibiotics (Clarithromycin ...) and Quinolon group (Ciprofloxacin, Levofloxacin, Norfloxacin ...).

Be careful when using mosaprid with the following drugs: anti -cholinergic drugs such as Atropin, Scopolamine, Butylscopolamin Bromid, Homatropin, Methanthelin ... because of the ability to reduce Mosaprid's effectiveness. Therefore, in case of simultaneous use with anti -cholinergic drugs, note the use of measures such as using spacing drugs.

Storage

Store at temperatures below 30 ° C, a cool dry place. Avoid light.

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