Valia 2mg medicine Abbott treats vascular disorders (1 blister x 30 tablets)

Dosage form Box of 1 blister x 30 tablets
Specifications Estradiol

Ingredient

Composition information	Content
Estradiol	2mg

Uses

Indications

Valiera 2mg drug is indicated in the following cases:

Treatment of symptoms of medium to severe vascular disorders related to menopause. There is no equivalent evidence that estrogen affects neurological symptoms or depression often occurs in menopause, so it does not only only treat these cases. Androgen (only used for temporary treatment). Estradiol and other estrogen plays an important role in the development and maintenance of the reproductive apparatus and the genital characteristics of women.

In many menopause women, the estradiol secretion stops vascular imbalance and regulates body temperature, causing symptoms of "hot loading", accompanied by excessive sweating sleep disorders and gradual atrophy of the genital - urinary movement. Estradiol replacement therapy reduces many of the above symptoms due to estradiol deficiency in menopausal women.

In most menopausal women, bone resorption increases due to estradiol deficiency that causes osteoporosis. As a result, the bone becomes sparse, weak, increasing fractures, especially broken vertebra, hip fractures and wrist bones. Osteoporosis is an important indication of estradiol treatment and has obvious results. The mechanism of action is mainly estrogen that reduces bone resorption. Estrogen used as supplements in the prevention of osteoporosis, not restoring the bone.

pharmacokinetic

absorption

Estradiol is well absorbed through the skin, mucosa and gastrointestinal tract.

Distribution

The drug is widely distributed in the body and has high concentrations in the target organs of the sex hormone. In the blood, there are about 60% estradiol associated with albumin, 38% combined with globulin bonding sex hormones and 2% in free form.

Metabolism

Estradiol metabolizes a lot of liver, mainly turns into estron, estriol and combined forms such as glucuronic or sulfate and glucuronic in the liver, excreting the complex substances in the bile into the intestine and followed by the reabsorption into the bloodstream.

Elimination

Estradiol is mainly excreted in the urine and a small amount in the feces, less than 1% of the raw excretion in the urine and 50 - 80% of the excretion in the form of a combination.

Before taking Valia 2mg medicine Abbott treats vascular disorders (1 blister x 30 tablets)

How to use

Oral drugs.

Dosage

In the treatment of medium to severe vascular symptoms, vulva and vaginal atrophy of menopause should start with the lowest dose of treatment and choose the regimen that can control those symptoms and then stop the drug as soon as possible.

Discontinuation or reduction should be conducted in each period of 3 to 6 months. The normal starting dose is 2 tablets - 1 tablet of 2mg suitcase, depending on the level of control of the patient's existing symptoms. The minimum maintenance dose is effective to determine by titration (increasing the dose from thought to the dose to achieve the effectiveness of treatment, using it is the maintenance dose). The use of drugs must be conducted in each cycle (for example: drink 3 weeks, stop 1 week).

Treatment for women is reduced estrogen secretion due to genital disability, cutting chamber or primary ovarian deficiency

The normal starting dose is 1/2 - 1 tablet of 2mg suitcase depending on the level of control of the patient's existing symptoms. The minimum maintenance dose is effective to determine by titration.

Progressive prostate carcinoma treatment Androgen dependent

recommended dose is 1/2 tablets - 1 tablet of suitaa 2mg, 3 times/day. The effectiveness of the treatment regimen can be assessed by determining the amount of phosphatase as well as improving the patient's symptoms.

Osteoporosis prevention

Should start treating osteoporosis with suitiera 2mg immediately after menopause as soon as possible. The daily dose is 0.5mg estradiol, taking a cycle (that is, taking 23 days, stopping 5 days) (using a suitcase 1mg, 2 capsules/day). The dose can be adjusted if necessary to control the existing symptoms of the patient. Stopping estrogen replacement therapy can repeat natural bone loss.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Overdose of estrogen can cause vomiting and vomiting and menstruation in women.

Overdose treatment includes symptomatic treatment and supportive treatment.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Valia 2mg, you may experience unwanted effects (ADR).

Urinary genitals: Changes in menstrual period and abnormal bleeding between menstruation or abnormalities in terms of menstruation, menstrual periods, speckled, increased cervical fibroids, vaginal candidiasis, changing the amount of secretions of the uterus.

Breast: Stretch and swelling.

Digestive: Nausea, vomiting, abdominal cramps, flatulence, jaundice, cholestasis, increased risk of gallbladder.

Skin: Skin tan or skin with age spots can survive even when stopping the drug, erythema, hemorrhage, hair loss, hairy hair in women.

Face: Increasing the curvature of the cornea, no contact lens tolerance.

Central nervous system: headache, migraine, dizziness, neurological inhibition, convulsions.

Other cases: Increase or weight loss, reduced carbohydrate tolerance, worsen porphyrin metabolic disorders, edema, change libido.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Valiera 2mg drug is contraindicated in the following cases:

Pregnant or suspected pregnancy. Estrogen can be harmful to the fetus when used for pregnant mothers.

Abnormal vaginal bleeding unknown cause.

Determine or suspect breast cancer, cervical cancer or other gynecological cancers.

Known or suspected the tumor depends on estrogen.

Patients with family history of gynecological cancer.

Progressive thrombosis or tyrant thrombosis.

Liver, kidney or heart disease.

Caution when using

The following cases should be special to use when using the drug:

Stimulates the creation of evil tumors: endometrial cancer, breast cancer, congenital lesions with the risk of evil.

gallbladder disease.

Cardiovascular disease.

Hypertension.

Hypercalcemia.

Warning

Be cautious when:

Simultaneous treatment with a progestin, cardiovascular risk, physical assessments, coagulation features, increased lipoprotein with family factors, water retention, uterine hemorrhage and breast pain, impaired liver function. Production.

The ability to drive and operate machinery

No report.

Pregnancy

Do not use drugs for pregnant women.

Breastfeeding period

A general rule, the appointment of any one for breastfeeding women only applies when really necessary because many drugs are excreted into breast milk. In addition, the use of estrogen for breastfeeding women has shown to reduce the quality and amount of milk.

Medicinal interaction

Concentrated use of estrogen -containing products with glucocorticoid drugs may affect their metabolism, when the selling time is prolonged, the treatment and toxicity of the drug will also increase. If used with drugs that can poison the liver, it can increase the toxicity of the drug to the liver, warn the patient when used with some other drugs (such as: Barbiturat, Phenylbutazol, HyDanToin, Rifampin) due to simultaneous use can reduce the effect of suitiera.

Reduce prothrombin time, Thromboplastin time and platelet agreement time increase the number of platelets, increase factors II, VII antigen, antigen VIII, increase the activity of blood coagulation factors No. VIII, IX, X, XII, VII - X, complex II - VII - X and Betathrombogulin III, Reducing the activity of threat resistance factor II, increasing fibrinogen levels and fibrinogen activity, increasing plasminogen antigen and its activity has been recorded.

Increased globulin concentration with the thyroid gland (TBG) leads to an increase in the total concentration of thyroid hormones circulating in the blood. Patients who are taking the thyroid replacement therapy must take a higher dosage.

Other serum protein binders can also increase (for example, corticosteroids attached to globulin, sex hormones associated with globulin) increase corticosteroid concentration and steroid hormones. Free hormone levels may decrease. Other plasma proteins may increase (Angiotensinogen/Renin, Alpha - 1 - Antitrypsin, Ceruloplasmin).

Increase HDL levels and sell HDL - plasma cholesterol, reduce cholesterol LDL levels, increase blood triglycerides.

Glucose tolerance disorders.

Reduce response to Metyrapon test.

can use ciclosporin with estrogen but must be cautious because of the potential to increase the concentration of ciclosporin, creatinine and transaminase in the blood. This phenomenon is caused by elimination of ciclosporin in the liver.

Storage

Keep the drug in a dry place, less than 30 ° C.

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