Valsartan Stella 40mg treatment for hypertension, heart failure (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Valsartan

Ingredient

Thành phần cho 1 viên

Composition information	Content
Valsartan	40mg

Uses

indications

Valsartan drugs indicated treatment in the following cases:

Hypertension.

Heart failure. Selective drugs on the AT1 receptor sub -responsible for the known effects of Angiotensin II. Angiotensin II concentration increases in plasma after the AT1 receptor is inhibited with Valsartan that can stimulate the AT2 receptor not inhibited, which has a balanced effect with the effect of the AT1 receptor. Valsartan does not show any activity of the owner of the AT1 receptor and has a much higher affinity (about 20,000 times) for the AT1 receptor compared to the AT2 receptor. Valsartan is not cohesive as well as blocking other hormone receptors or ion channels known to be important in the cardiovascular regulation.

Valsartan does not inhibit angiotensin transferring enzymes (also known as Kininase II), which converts angiotensin I into angiotensin II and degenerative bradykinin. Because there is no effect on angiotensin transfer enzymes and not further strengthening bradykinin or p substrate, Angiotensin II antagonists are not sure to be related to them.

Dynamic pharmacokinetics

Valsartan are quickly absorbed after drinking with bioavailability about 23%. The peak concentration of Valsartan in plasma is reached 2-4 hours after a dose. About 94 - 97% of the drug associated with plasma proteins. Valsartan is insignificant metabolized and is excreted mainly through the honey in a constant form. Selling time is about 5 - 9 hours.

After drinking, about 83% of the drug is eliminated through feces and 13% in urine.

Before taking Valsartan Stella 40mg treatment for hypertension, heart failure (3 blisters x 10 tablets)

How to use

Valsartan Stella 40mg is used orally, regardless of the meal, should be taken with water.

Dosage

Hypertension:

The starting dose of 80 mg x 1 time/day. The dose can be increased to 160 mg x 1 time/day if necessary, however can increase to 320 mg x 1 time/day.

The starting dose is lower than 40 mg x 1 time/ day for people over 75 years old, and people reduce the inner volume; Recommended reduction of dose on liver failure or kidney failure.

heart failure:

The starting dose of 40 mg x 2 times/day. When tolerated, the dose should be increased to 160 mg x 2 times/day.

after myocardial infarction:

Valsartan can start early 12 hours after myocardial infarction in patients with stable clinical patients, the dose starts 20 mg 2 times/day, can double the dose in the period of the next few weeks to 160 mg x 2 times/day if tolerance.

Patients with mild to medium liver damage, maximum dose not exceeding 80 mg/day.

No dose adjustments in patients with creatinine clearance> 10 ml/min and on elderly patients.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Data overdose in humans is limited. The most common expression of overdose is hypotension and tachycardia; It is also possible to occur slowly due to sympathetic nerve stimulation (vagus nerves). Reducing the level of awareness, circulation and shock were reported.

Handling

If symptoms of hypotension occur, supportive treatment should be conducted. Valsartan is not excluded through hemorrhage.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Valsartan Stella 40mg drugs often experience unwanted effects (ADR) such as:

Common, ADR> 1/100

Nervous system: Dizziness, dizziness when changing posture.

ears and mesmerizing: Dizziness. circuit.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Valsartan Stella 40mg drugs in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

hyperkalemia: It is not recommended to simultaneously use with potassium supplements, potassium diuretic, alternative salts containing potassium or other drugs that may increase potassium levels (such as heparin ...).

Double blockade of the renin-ankiotensin-aldosteron system (RAAS): There is evidence that the use of the enzyme inhibitors transferred Angiotensin, the Angiotensin II or Aliskiren receptor blockers increases the risk of lowering blood pressure, increased potassium and impaired renal function (including acute renal impairment). Do not simultaneously use angiotensin transfer enzymes and angiotensin II receptor blockers in patients with diabetes kidney disease.

Patients with salt and/or fluid loss: on patients with salt and/or severe loss of epidemic, as those who are taking high diuretic dose, symptoms of lowering blood pressure may occur in some rare cases after the beginning of Valsartan treatment. Recommendation of the starting dose of 40 mg for patients who cannot reduce diuretics to adjust salt loss and/or epidemic loss.

Kidney artery stenosis: Because other drugs affect the Renin-Anotensin-Ordosteron system that can increase serum blood urea and creatinine in patients with kidney stenosis on both sides or one side, it is necessary to monitor as a safe measure.

Hepatic failure: According to pharmacokinetic data, the plasma valsartan concentration increases significantly on patients with mild to medium liver failure, recommending lower doses in hypertension patients.

Renal failure: As a result of inhibition of the renin-angiotensin-aldosteron system, blood urea, serum creatinine and renal function changes including kidney failure (very rare) have been reported specifically in patients with previous renal function or patients with severe heart failure.

Should monitor serum potassium concentration in patients with renal failure or on the elderly if they are taking potassium supplements.

Patients after myocardial infarction: As a result of inhibiting the Renin-Anotensin-Aldosteron system, the change in renal function can be anticipated in sensitive individuals. Evaluation of patients after myocardial infarction must always include kidney function assessment.

Valsartan contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose.

The effect of the drug on the ability to drive and operate machinery

When driving or operating machinery, it should be noted that occasionally dizziness or fatigue may occur during treatment with any hypertension.

Use drugs for women during pregnancy and lactation

Pregnant women: If detected pregnancy, should stop using Valsartan as soon as possible.

Lactating women: decide to stop breastfeeding or stop taking the drug after considering the importance of the drug for the mother.

Drug interaction

has not seen clinical significance when Valsartan combined with amlodipine, Atenolol, cimetidine, digoxin, furosemid, glyburric, hydrochlorothiazid or indomethacin.

The combination of Valsartan and Atenolol increases the anti -hypertension effect rather than using individually, but the heart rate reduction effect is not equal to only using single atenolol.

Combining Valsartan with Warfarin does not change Valsartan's pharmacokinetics or Warfarin's anticoagulant time.

Interacting with CYP 450: The enzyme is not responsible for transforming Valsartan but not the CYP 450 isozym.

As well as other blockers or other impact on Angiotensin II, used in combination with potassium -saving diuretic (such as Spironolacton, Triamteren, Amilorid), Potassium supplements or salt -containing salt -containing potassium drugs that can lead to increased serum potassium levels and on heart failure patients can increase serum creatinine levels.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.