Vanoba Farmaprim vaginal vagina treats vaginitis, itching (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Metronidazol, miconazole nitrate

Ingredient

Thành phần cho 1 viên

Composition information	Content
Metronidazol	100mg
Miconazole nitrate	100mg

Uses

Indications

vanobi drugs are indicated in the following cases:

Local therapy for cases of vaginitis damaged, itchy due to many different causes:

vanobi is indicated in vaginal and urethral infection. Vaginal vulva. This effect is due to the combination of:

Metronidazol is a derivative 5 - nitro - imidazole, has a broad antibacterial activity on protozoa such as amoeba, Giardia Lambia and in anaerobic bacteria. Metronidazole has bactericidal effects on bacteroides, fusobacteriuml and other mandatory anaerobic bacteria but does not work on noni bacteria.

The mechanism of action of Metronidazol is not very clear. In parasites, group 5 - nitro of the drug is reduced into toxic mediators to cells. These substances bind to the twisted structure of the DNA molecule that breaks these fibers and eventually causes dead cells.

Metronidazole is only resistant to a few cases. However, when using Metronidazol alone to treat Campylobacter, Helicobacter pylori, the drug resistance is growing too fast. When infected with both anaerobic and anaerobic bacteria, Metronidazole must be combined with other antibacterial drugs. Tricomonas vaginalis infection can be treated with Metronidazol oral oral use. Both women and men must be treated, because men can carry pathogens without symptoms. In many cases, it is necessary to treat vaginal drugs and tablets. When bacterial/vaginal inflammation is caused by bacterial/vaginal inflammation, Metronidazole will cause the vaginal bacteria to return to normal, in the majority of patients taking drugs, Metronidazole does not impact the normal vaginal bacteria.

Miconazol is a synthetic imidazol drug that has anti -fungal effects on types such as Aspergillus, Blastomyces, Candida, Cladosporium, Coccidioides, Epidermophyton, Histoplasma, Madurella, Pityrosporon, Microsporton, Paracoccioides, Phialoophora, PhialoPhoria and Pseudalleschera Trichophyton. Miconazole also works with Gram -positive bacteria. Miconazole inhibits the synthesis of ergosterol in the fungal cell membrane that inhibits the growth of fungal bacteria cells.

pharmacokinetics

metronidazol:

absorption: The absorption of metronidazol in the vaginal line is about 20% of the dose. Metronidazol from vaginal bullets that have a bioavailable body about 20-25% (or about 56% of venous bioavailability). The peak concentration of serum is slower than oral or rectal (within 8 - 24 hours). Metronidazole is quickly distributed into most tissues, and is detected in the lungs, kidneys, liver, skin, saliva, semen, and vaginal discharge. Metronidazole is in cerebrospinal fluid, the drug can be passed through the placenta and is excreted in the milk. The distribution of metronidazol is about 0.5 liters to 1.1 liters in adults. Half of the half -life of Metronidazol in plasma is about 6-8 hours and hydroxyl metabolites are about 9.5 - 19.2 hours. Half lifetime elimination is not affected when impaired renal function, may be prolonged when impaired liver function (may be up to 10.3 - 29.5 hours). The metabolites in the urine of Metronidazol are the main results from the oxidation of the chain [1 - (ß Hydroxyethyll) - 2 - Hydroxymethyl - 5 - Nitroimidazol and 2 - Methyl - 5 - Nitroimidazole - 1 - Ylacetic Acid] and Glucuronid complex, with metronidazol levels that do not change about 20% of the total total total total total total total total total overall. Hydroxyl metabolites also have microbiological activity.

absorption: on the vaginal lines, a small amount of miconazole is absorbed the whole body. After 6 daily applications, the treatment of candidiasis in vaginal vulva (14 -day treatment regimen) The average peak concentration reaches 4.2 nanogam/ml, the serum concentration does not increase during the remaining treatment period. After treating a single dose of cream or vaginal bullet for healthy women, about 1% of the dose is seen in urine and feces.

Before taking Vanoba Farmaprim vaginal vagina treats vaginitis, itching (2 blisters x 5 tablets)

How to use

Note when using and instructions for vaginal placement

Before ordering, put the pill in the refrigerator compartment to freeze the drug (about 10 - 30 minutes), wash the vagina. Drugs.

The maintenance of this dose continues for a few more days, after the symptoms have gone.

The treatment time and the dose are specified by the doctor in each patient case.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Using high doses may have symptoms: nausea, vomiting, abdominal pain, metal flavor, loss of air conditioning, headache, eyes, paresthesia, convulsions, leukopenia, black urine dyed, anorexia, diarrhea.

Treatment: Symptomatic treatment, if overdose due to eating, gastric lavage.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

Gastrointestinal disorders:

Unknown: abdominal pain, spasms, metal flavor, dry mouth, constipation, diarrhea, anorexia, nausea, vomiting.

Popular: headache

Unpopular: anxiety, unstable emotional.

Vestibular and hearing disorders:

Popular: Dizziness.

Hematology and lymphatic disorders:

Unknown: leukopenia.

immune system disorders:

Unknown: allergic reactions (skin rash, including urticaria).

Rare: irritation (burning, itching), especially at the beginning of the therapy.

Instructions on how to handle ADR:

With local side effects such as burning, mild and transient itching, it is not necessary to stop therapeutic, because this symptom is due to the activity of the drug on the inflamed vaginal mucosa.

Stop therapeutic if these symptoms are severe and progress:

Stop therapeutic treatment when dizzy, confusion, loss of air conditioning.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

VANOBER drugs contraindicated in the following cases:

Patients with Metronidazol and/or Miconazol and other imidazol derivatives. Porphyrin metabolism disorders.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Bullets should only use vaginal lines, do not swallow or use by other lines.

While using the drug, patients should avoid sex. The use of bullets can reduce the reliability of mechanical contraception (condoms and vaginal diaphragm) due to the interaction of the bullet with the film or rubber. However, this characteristic of the drug does not exclude the microbiological analysis of the previous product.

metronidazol:

Metronidazol has the effect of inhibiting Alcohol Dehydrogenase and other alcohol oxidation enzymes. The drug has a mild disulfiram -style reaction such as hot face, headache, nausea, vomiting, abdominal spasms and sweating. Need to monitor and do not use alcohol and alcoholic preparations when taking the drug. Vitro and significantly increase the ratio of tumor in the liver in mice when using high doses for a long time. Therefore, it is necessary to be cautious and only use Metronidazol high doses, long-term treatment when necessary to treat serious diseases, consider the benefits and risks that may occur. Therefore, the results of the liver enzyme test (ALT, AST, Hexokinase Glucose, Lactat Dehydrogenase, Triglycerid) may be affected so it should be noted and reviewed.

miconazol:

vaginal cream and vaginal pellets containing miconazole can damage latex products (diaphragm to avoid conception and rubber bags). ketoconazole).

Avoid contact with eyes.

The effect of drugs on driving and operating machinery

does not affect.

Use drugs for women during pregnancy and lactation

Pregnant women:

The safety of the drug when used for pregnant women has not been established, so it should not be used in this period.

breastfeeding period:

Metronidazol excreted breast milk quite quickly, the concentration of drugs in the sinking of the breastfeeding can be about 15% of the mother's plasma concentration. Caution should consider using this period. Consider stopping breastfeeding when using the drug. Can resume breastfeeding after 24-48 hours after treatment.

Medicinal interaction

Miconazole: A small amount of miconazole nitrate is absorbed the whole body when using vaginal lines, so the level of interaction with other drugs is low. The drug interaction is mainly due to the composition of Metronidazol. Therefore, do not simultaneously use these two drugs to avoid nervous effects such as psychosis, confusion. > Metronidazole increases the effect of vecuronium is a non -reducing muscle relaxant. Plasma. Metronidazol + miconazole can change the concentration of theophyllin and process in plasma, when used simultaneously.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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