Vashasan medicine 20mg Hasan treats angina (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

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Composition information	Content
Trimetazidine	20mg

Uses

indications

Vashasan 20 drugs are indicated in the following case:

appoint adults in supplementary therapy/support for existing treatments to treat symptoms in patients with stable angina without adequate control or non -tolerated patients with other angina therapy.

Trimetazidin inhibits the beta oxidation of fatty acids by inhibiting 3-ketoacyl-coa thiolase-chain enzymes in ischemic cells, energy obtained during glucose oxidation needs less oxygen consumption than oxidation beta. Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effect

In patients with local heart anemia, trimetazidine acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidin has anti -anemia effect but does not affect hemodynamics.

pharmacokinetic

absorption

Trimetazidin when taken is absorbed very quickly and reaches the peak concentration in plasma before 2 hours from drinking. The maximum concentration of the drug in plasma after taking a single dose of trimetazidin 20 mg reaches about 55 ng/ml.

The equilibrium of the drug in the blood is about 24 to 36 hours after repeating a dose and very stable during treatment.

Distribution

The integral distribution of 4.8 liters/kg shows the good diffusion level of the drug to the tissues. Low protein attachment ratio, measured value in vitro is 16%.

Metabolism and elimination

Trimetazidin's waste time is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking Vashasan medicine 20mg Hasan treats angina (2 blisters x 30 tablets)

How to use

Vashasan 20 medicine is taken orally. Drink with meals.

Dosage

A tablet of 20 mg/time x 3 times/day.

Special subjects

Patients with average renal failure (Creatinine clearance 30 - 60 ml/minute)

Dosage recommended is 1 tablet 20 mg/time x 2 times/day, morning and evening, with meals.

Elderly patients

Elderly patients may have a higher level of trimetazidine sensitivity than normal due to the decline in kidney function by age. For patients with average renal impairment (Creatinine clearance 30 - 60 ml/min), the recommended dose is 1 tablet 20 mg/time x 2 times/day, morning and dark, use with meals. Be careful when calculating the dose for elderly patients.

Children

Safety and effectiveness of trimetazidin for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

What to do when using overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Vashasan 20, you may experience unwanted effects (ADR).

Common

Dizziness, headache.

Brushing the chest, nervous, extra -syllable, heartbeat. Rest, other relevant movement disorders, often recovered after stopping the drug.

Notify your doctor any unwanted effects related to medication.

Warnings

This drug is only used by a doctor.

Do not use overdue drugs indicated on the packaging.

Do not use the prescribed overdose.

Notify the doctor with unwanted effects when using the drug.

If you need more information, please consult a doctor.

Contraindicated

Vashasan 20 drugs are contraindicated in the following cases:

Hypersensitivity to trimetazidin or any ingredients of the drug.

Caution when used

This drug is not used to treat angina or not used to start with unstable angina, myocardial infarction.

Hypersensitivity to trimetazidine can cause or seriously seriously symptoms Parkinson (Run, slow movement and difficulty, increase muscle tone), so patients, especially elderly patients, need regular check and monitor. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as: Parkinson symptoms, irritability, tremor, unstable gaits need to stop using trimetazidin immediately. These cases occur and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the stop, it is necessary to consult neurologists.

may have a self, unstable gait or hypotension, especially in patients who are taking medications for hypertension.

Be careful when prescribing trimetazidin for patients with high sensitivity levels: Patients with renal impairment average, patients over 75 years old. When used for pregnant or lactating women, it is advisable to consider effectiveness and consequences.

The ability to drive and operate machinery

trimetazidin can cause symptoms: dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

Animal research results have not yet confirmed whether or not the trimetazidin's teratogenic effect. There is not enough clinical evidence to eliminate the risk of fetal defects.

The best does not use trimetazidin during pregnancy.

Breastfeeding period

There is no evidence of the presence of trimetazidin in breast milk, so it is best not to breastfeed during trimetazidine treatment.

Medicinal interaction

There has been no interaction with any drug. Trimetazidin is not an induction drug as well as not a drug that inhibits the liver metabolic enzyme in the liver. Thus, it is more likely to trimetazidin does not interact with many metabolic drugs in the liver. Be careful to monitor when coordinating with other drugs.

Storage

Where dry, less than 30 ° C. Avoid light. Leave the medicine out of reach of children.

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