Vashasan mr 35 Hasan medicine treats angina (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	35mg

Uses

indications

Vashasan mR medicine is indicated in the following cases:

Indications for adults in supplementary therapy/support for existing treatment to treat symptoms in patients with stable angina is not fully controlled or the patient is not tolerated with other angina treatment therapy.

Pharmacokology

Mechanism of action

Trimetazidin inhibits the oxidation of fatty acids by inhibiting the 3-ketoacyl-coa thiolase long-chain enzymes in ischemic cells, energy obtained during glucose oxidation needs to consume less than the oxidation beta.

Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effect

In patients with ischemic heart anemia, trimetazidine acts as a metabolic substance, which helps conserve high intracellular energy levels in myocardial cell.

Trimetazidin has anti -anemia effect but does not affect hemodynamics.

pharmacokinetic

trimetazidin when taken is absorbed very quickly and reaches the top concentration of plasma before 2 hours from drinking. The maximum concentration of the drug in plasma after taking a single dose of trimetazidin 20 mg reaches about 55 ng/ml.

The equilibrium of the medication in the blood is reached from 24 - 36 hours after repeating a dose and is very stable during treatment.

The integral distribution of 4.8 liters/kg shows the good diffusion level of the drug to the tissues. Low protein attachment ratio, measured value in vitro is 16%.

Trimetazidin's waste time is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking Vashasan mr 35 Hasan medicine treats angina (2 blisters x 30 tablets)

How to use

Take 1 Vashasan MR tablet in the morning and 1 evening pill with a cup of water at meals.

Dosage

Dosage: 1 tablet/time x 2 times/day.

Special subjects

Patients with average renal failure (Creatinine clearance 30 - 60 ml/minute)

recommended dose is 1 capsule, drink in the morning, have a meal.

Elderly patients

Elderly patients may have a higher level of trimetazidine sensitivity than normal due to the decline in kidney function by age.

For patients with average renal impairment (30 - 60 ml/minute creatinine clearance)

Dosage recommended is 1 capsule, drink in the morning, use with meals.

Be careful when calculating the dose for elderly patients.

Children

Safety and effectiveness of trimetazidin for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Vashasan MR, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Dizziness, headache.

No report.

Heart: Brushing the chest, nervous, extra -syllable, fast heartbeat.

Neurological: Parkinson symptoms (Run, slow movement and difficulty, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, can often recover after stopping the drug. Sleep disorders (insomnia, drowsiness). ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vashasan mR drugs are contraindicated in the following cases:

Hypersensitivity to trimetazidin or any ingredients of the drug.

Caution when used

This drug is not used to treat angina or not used to start with unstable angina, myocardial infarction.

Trimetazidin can cause or worsen Parkinson's symptoms (tremor, slow and difficult exercise, increase muscle tone), so patients, especially elderly patients, need regular check and monitor. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, irritability, tremor, unsteady gaits need to stop using Trimetazidin immediately.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the stop, it is necessary to consult neurologists.

may have a self, unstable gait or hypotension, especially in patients who are taking medications for hypertension.

Be careful when prescribing trimetazidin for patients with high sensitivity levels: Patients with average renal impairment, patients over 75 years old.

When used for pregnant or lactating women, it is advisable to consider effectiveness and consequences.

The ability to drive and operate machinery

trimetazidin can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

Animal research results have not been confirmed for sure whether or not the trimetazidin teratogenic effect.

There is not enough clinical evidence to eliminate the risk of fetal defects.

The best does not use trimetazidin during pregnancy.

Breastfeeding period

There is no evidence of the presence of trimetazidin in breast milk, so it is best not to breastfeed during trimetazidine treatment.

Medicinal interaction

There has been no interaction with any drug. Trimetazidin is not an induction drug as well as not a drug that inhibits the liver metabolic enzyme in the liver. Thus, it is more likely that trimetazidin does not interact with many metabolic drugs in the liver. Need to be careful when coordinating with another drug.

Storage

Where dry, less than 30 ° C. Avoid light.

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