VasPycar MR 35mg Pymepharco treatments for stable angina (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	35mg

Uses

Indications

vastarel mR is indicated in the following cases: For adults in supplementary/supportive therapy in existing therapy to treat symptoms in patients with stable angina unproving control or non -tolerant patients with other therapies.

Pharmacokology

By preserving energy metabolism in cells deficient in oxygen or ischemic, trimetazidine Room is reduced in intracellular ATP, thus ensuring the ion pump function and K/Na channel penetrate the membrane while maintaining endothelial balance of cell tissue.

Trimetazidine inhibits the oxidation of fatty acids by inhibiting Long - Chain 3 Ketoacyl - CoA thiolase enzymes in ischemic cells, energy obtained during glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia. In patients with ischemia, trimetazidine acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidine has anti -anemia effect but does not affect hemodynamics.

pharmacokinetic

absorption

After drinking, the maximum concentration is achieved after 5 hours. After 24 hours, the drug concentration in plasma remains at the upper level or equivalent to 75% of the maximum concentration in 11 hours. Stable state reached the latest after about 60 hours. Pharmacokinetic characteristics of Vastarel MR are not affected by food.

Distribution

The distribution integration is 4.8L/kg. The drug is associated with low plasma proteins, measuring in vitro for 16%.

Elimination

Trimetazidine is excreted mainly in urine in constant form. Vastarel MR's exhaust time is 7 hours in young volunteers and 12 hours in people over 65 years old. Purification of trimetazidine parts is largely through the kidneys that directly related to the clearing of creatinine, at less than the liver purification, the purification of the liver decreases with age.

Before taking VasPycar MR 35mg Pymepharco treatments for stable angina (2 blisters x 30 tablets)

How to use

Oral drugs.

Dosage

Dosage is 1 tablet 35mg trimetazidine, 2 times daily, use with meals.

The benefits of drug use should be assessed after 3 months of treatment, if the patient does not respond to treatment, it is advisable to stop trimetazidine.

Patients with average renal failure

For patients with average renal failure (Creatinine clearance 30 - 60ml/min), the recommended dose is 1 tablet of 35mg/day, in the morning, use with breakfast.

Elderly patients

Elderly patients may have a higher level of trimetazidine sensitivity than normal due to age impairment. For patients with average renal impairment (clearine clearance of 30 - 60ml/minute), the recommended dose is 1 tablet of 35mg/day, in the morning, use with breakfast. Be careful when calculating the dose for elderly patients.

Children

The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

If the effect of Vasarel MR is too strong or too weak, must notify the doctor or pharmacist.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting a dose? Do not increase the dose doubled to forget the dose.

Side Effects

When using vastarel mR , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Dizziness, headache .

digestive: abdominal pain, diarrhea , indigestion, nausea, vomiting. Systemic: weakness.

Rare, 1/10000

Heart: Brushing chest drum, suspense, extra mind, fast heartbeat.

Vascular: Hypertension artery, hypotension, can lead to discomfort, dizziness or falling, especially in patients being treated with anti -hypertension drugs, flushing.

Not determined frequency

Neurological: Parkinson's symptoms (Run, slow and difficult movement, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders, can often recover after stopping the drug, sleep disorders.

digestive: constipation .

Skin: External pustules (AGEP), Evaluation. blood: granulocytosis, thrombocytopenia, thrombocytopenic banner. liver: hepatitis.

Instructions on how to handle ADR

Notify your doctor any unwanted effects related to medication.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vastarel MR contraindicated in the following cases:

Too hypersensitivity to the active ingredient or any excipient is listed in the formula of product preparation.

Parkinson patient, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.

Severe renal failure (Creatinine clearance

Be cautious when using

In general, do not recommend this medication during breastfeeding.

Do not use this medication for patients while suffering angina, or not prescribed to treat unstable angina. This drug is also not used to treat myocardial infarction.

When angina pain, notify the doctor immediately. The tests may be needed and may have to change the treatment regimen for the patient.

Trimetazidine can cause or worsen Parkinson's symptoms (Run, slow movement and difficulty, increase muscle tone). Therefore, patients especially elderly patients need to be checked and monitored regularly. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson symptoms, irritation, tremor, unsteady gait, should immediately stop using trimetazidine. These cases occur and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after stopping the drug, it is necessary to exchange with neurologists.

may have an expression of self, unstable gait, or hypotension, especially in patients who are taking hypertension drugs.

Needs needed for a prescription trimetazidine for patients with high sensitivity levels such as patients with average renal impairment, patients over 75 years old.

The ability to drive and operate machinery

trimetazidine can cause dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

better not to use this medication during pregnancy. If you find yourself pregnant while taking the medication, consult your doctor because only the doctor can beat the need to continue using this medication.

Breastfeeding period

There is currently no data on the excretion of the drug through breast milk, should not be breastfeeding during treatment. Must consult a doctor or pharmacist when taking any medicine.

Drug interaction

To avoid drug interactions that may occur between drugs, it is necessary to notify your doctor or pharmacist if you are currently being treated any other drug.

Storage

To be out of reach and reach of children.

Do not use overdue drugs on the box.

This drug is not thrown into wastewater and domestic waste. Ask the pharmacist how to throw away drugs if not used. These measures will help protect the environment.

Storage conditions: Under 30 ° C.

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