Vastarel 20mg Servier Treatment Treatment (60 tablets)

Dosage form Box of 60 capsules
Specifications Trimetazidine

Ingredient

Composition informationContent
Trimetazidine20mg

Uses

Indications

Vastarel 20 mg is indicated in the case:

Vastarel 20 mg is indicated for adults in additional therapies to support existing treatments to treat symptoms in patients with stable angina without adequate control or non -tolerated patients with other angina therapy.

Pharmacokinus

trimetazidine inhibits the beta oxidation of fatty acids by inhibiting dragon enzymes 3 ketoacyl-coa thiolase, stimulating glucose oxidation. In ischemic cells, energy obtained during oxidation of glucose has less oxygen consumption less than the oxidation beta process will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effect

In patients with ischemic anemia, trimetazidine acts as a metabolic substance, which helps conserve high intra -intra -intra -intra -intra -intra -intracellular energy levels in myocardial cell. Trimetazidine has anti -anemia effect but does not affect hemodynamics. Due to the conservation of energy metabolism in cells reduced tissue oxygen or anemia, trimetazidine prevents the reduction of intracellular ATP levels, thus ensuring the activity of ionic pumps and sodium-peri-peri-membrane flows, while maintaining endothelial balance.

In animals, trimetazidine:

Helps maintain energy metabolism in the heart and sensory nerves in ischemic attacks.

Intracellular (acidic) reduction and changing ionic flow through the membrane caused by ischemia.

Reducing the movement and infection of the multi -core neutrophils into ischemic heart tissue and into the heart tissue. Also reduces the size of experimental infarction.

has this effect without any direct hemodynamic effect.

In humans, studies with control patients with angina patients shows trimetazidine:

  • Increase coronary flow, thus slow down the onset of ischemic anemia due to exertion from the 15th treatment.
  • gives significantly reducing the use of trinitroglycerin.

    After drinking, trimetazidine is absorbed quickly and the peak concentration in plasma is reached within 2 hours. After a single dose of 20 mg trimetazidine, plasma peak concentration is about 55 ng/ml. While repeating, stable state is achieved after 24 hours to 36 hours and remains stable during the treatment period.

    Distribution:

    The distribution volume is 4.8 l/kg, suggesting that the diffusion is good in the tissue. Low protein mounting ratio, in vitro mounting ratio is 16%.

    Era:

    Trimetazidine is excreted mainly in urine, in a constant form. Selling time is about 6 hours.

    • Before taking Vastarel 20mg Servier Treatment Treatment (60 tablets)

    How to use

    oral medications for meals.

    Dosage

    A tablet of 20 mg/time x 3 times/day, with meals.

    Patients with average renal impairment (Creatinine clearance 30 - 60 ml/minute):

    Dosage recommended is 1 tablet of 20 mg/time x 2 times/day, morning and evening, with meals.

    Elderly patients:

    Elderly patients may have a higher level of trimetazidine sensitivity than normal due to the decline in kidney function by age. For patients with average renal impairment (Creatinine clearance 30 - 60 ml/min), the recommended dose is 1 tablet 20 mg/time x 2 times/day, morning and dark, use with meals. Caution should be careful when calculating the dose for elderly patients (see more contraindications and warnings and caution).

    Children:

    The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated. There is currently no data on this patient object. In all cases, it is necessary to strictly follow the prescription of the doctor.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Notice immediately to the doctor.

    What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    When using vastarel 20 mg , you may experience unwanted effects (ADR).

    Nervous system disorders

    Common

  • Dizziness, headache .

    • Unknown:

  • Symptoms Parkinson (Run, slow movement and difficulty, increase muscle tone), unstable gait, non -stop neurological syndrome, other relevant movement disorders, can often recover after medication. Sleep disorders (insomnia, drowsiness).

    • Disorders on the heart

    Rare:

    Brushing chest drum, suspense, extra mind, fast heartbeat.

    Disorders on the circuit

    Rare:

    Aortic hypotension, vertical hypotension, can lead to discomfort, dizziness or fall, especially in patients being treated with anti -hypertension drugs, flushing.

    Stomach -intestinal disorders

    Common

  • Abdominal pain, diarrhea , indigestion, nausea and vomiting.

    • Unknown:

  • Constipation.Common

    rash, itching, urticaria .

    Unknown:

    Excavity of the acne (AGEP), angioedema.

    Systemic disorders and drug use

    Common

  • weakness.

    • Instructions on how to handle ADR:

    When encountering side effects of the drug, it is necessary to notify the doctor for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindications

    Do not use Vastarel 20 mg film tablets in the following cases:

  • Hypersensitivity for active ingredients or any excipients listed in the formula for product preparation.

    Be cautious when using

    In general, do not recommend this medication during breastfeeding.

    Do not use this medication for patients while suffering angina, or do not use drugs to treat unstable angina. Do not use drugs to treat myocardial infarction.

    Notice immediately to the doctor when angina. May need to do more tests and change the treatment regimen.

    Trimetazidine can cause or worsen Parkinson's symptoms (Run, slow and difficult exercise, increase muscle tone), so patients, especially elderly patients, need regular checks and monitoring. In suspicious cases, patients need to be taken to neurologists for appropriate examination. When encountering movement disorders such as Parkinson's symptoms, feet syndrome, tremor, unstable gait, it is necessary to immediately stop using trimetazidine.

    These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after taking the drug, it is necessary to exchange with neurologists.

    may have a self, unstable gait or hypotension, especially in patients who are taking medications for hypertension.

    Be careful when prescribing trimetazidine for patients with high sensitivity levels such as:

  • Patients with average renal failure.

    • Patients over 75 years old.

    This drug contains FCF S (E 110) and Cochineal A (E 124) and can cause allergic reactions.

    The ability to drive and operate machinery

    trimetazidine can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

    Pregnancy

    better than not taking this medication during pregnancy. If you find pregnancy during the time you are taking the medication, you should immediately ask the doctor because only the doctor can assess the need for continuing treatment.

    Breastfeeding period

    There is currently no data on the excretion of the drug through breast milk, should not be breastfeeding during treatment. The general rule is to notify the doctor or pharmacist before taking any drug in the event of pregnancy or nursing.

    Medicinal interaction

    In order to avoid possible drug interactions, it is necessary to notify the doctor and pharmacist the treatment you are in use.

    Storage

    In a dry place, avoid light, temperatures below 30⁰C.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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