Vataxon skin ointment 15g m/s bio-labs for short-term treatment of skin diseases

Glucocorticoid has the following metabolic effects: The blood glucose level is maintained or increased due to the use of peripheral glucose and increasing glucose; Glycogen deposits, protein decomposition, lipid decomposition of lipids affect the absorption of calcium and excretion leading to reducing the amount of calcium reserves in the body. Glucocorticoid facilitates many endogenous active substances, affecting the function of the cardiovascular, kidney, skeletal and central nervous system.

Clobetasol Propionate used in skin is anti -inflammatory effect due to the synthesis of chemical mediators that cause inflammation and inhibitors that release chemical mediators that cause allergic reactions such as histamine, bradykinin, serotonin.

Due to less mineralocorticoid effect, Clobetasol Propionat is very suitable in cases where the pathology that holds water is disadvantage. High doses, Clobetasol Propionate has a immunosuppressive effect.

Dynamic pharmacokinetics

Clobetasol propionat is less absorbed through the skin, or is used to treat atopic dermatitis. However, when applying these preparations on the skin, they also have the ability to absorb a certain amount of drugs. In particular, when the skin is damaged or covered with skin after applying the drug, the ability to absorb the drug through the skin will increase. There are many factors that can affect the skin absorption of steroid drugs: oil body and solubility, drug concentration, anatomical position, patient age, the presence of skin diseases and external iron all affect the treatment effect of corticosteroids used on the skin.

The peak concentration of the plasma of Clobetasol Propionat is about 0.63ng/ml achieved after 8 hours when taking the second dose for normal people. In a separate study, the peak concentration of plasma is about 2.3ng/ml and 4.6ng/ml respectively in patients with psoriasis and Eczema reached 3 hours after taking a single dose.

Metabolic drugs mainly in the liver and then excreted by the kidneys.

As with other corticosteroids, contraindicated use of clobetasol for patients with diabetes, mental illness, stomach and duodenal ulcer, in bacterial infections and viral infections, in body fungal infections and in patients with hypersensitivity to Clobetasol or with other corticosteroids or any part of the preparation.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

The lowest -dose of corticosteroids must be used for controlled treatment; When reducing the dose, it must gradually decrease step by step under the medical supervision. The long -term continuous treatment should be avoided with Clobetasol if possible, especially for babies and young children, because it may occur in the adrenal gland inhibitor, even if the area is not covered with the medication. Prolonged corticosteroids can cause glass chisel (especially in children), glaucoma with the ability to damage the optic nerve.

When using the whole body corticosteroids must be very cautious in case of congestive heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucoma, thyroid defect, liver failure, osteoporosis, stomach ulcers, mental disorders and kidney failure. Children can easily increase the risk of some unwanted effects, in addition corticosteroids can cause growth; Elderly people also increase the risk of unwanted effects.

In case of using Clobetasol for children, it is recommended that the treatment prescription needs to be checked weekly by the physician. It should be noted that the diapers of children are acting as when the skin is covered with medicine.

When treated continuously for a long time, Clobetasol can cause skin atrophy, especially on the face.

Memorize this when treating skin diseases such as psoriasis, lupus erythema disc and severe dots. When applying the drug on the skin around the eyes, it is necessary to be careful not to let the drug fall into the eyes, because it can cause glaucoma.

During the long -term corticosteroid therapy, patients must be monitored regularly. May need to reduce sodium and add calcium and potassium.

Located corticosteroids to treat psoriasis can cause risks such as recurrence, oily pills, puu psoriasis, and the ability to poison local or body toxicity due to damaged skin barrier function. When using corticosteroids to treat psoriasis, careful monitoring of patients.

When infected with infection, the appropriate antibiotic treatment should be treated. When signs of infection spread, it is necessary to stop using corticosteroids in the skin and need to treat systemic antibiotics. When the skin is applied to the skin, the skin becomes moist and moist, which will facilitate the growth of infection, so it is necessary to wash the skin before applying the drug and put it clean on top.

Wide or repeated use may increase the risk of skin sensitivity due to contact.

The effect of the drug on the ability to drive and operate machinery

unknown effects of the drug.

Use drugs for women during pregnancy and lactation

Pregnant women:

There is no data on the effects of clobetasol on pregnant women. However, pregnant women should not be because of the drug in large amounts or for a long time.

breastfeeding women:

Clobetasol's safety when used for breastfeeding mothers has not been set up. Should be cautious and only take medicine during breastfeeding if really necessary.

Interactive drug

The ability to interact between topical drugs and other drugs rarely occurs under common conditions.

paracetamol: corticosteroids induce liver enzymes, which can increase to form a metabolic of toxic paracetamol to the liver. Therefore, an increased risk of liver toxicity if corticosteroid is used with high doses of paracetamol.

Triple -round antidepressants: These drugs do not reduce and may increase mental disorders caused by corticosteroids; Do not use these antidepressants to treat the aforementioned adverse effects.

Oral or insulin anti -diabetic drugs: glucocorticoid may increase blood glucose levels, so it may be necessary to adjust the dose of one or both drugs when used simultaneously; It may also be necessary to adjust the dose of hypoglycemic drugs after stopping glucocorticoid therapy.

glycosid digitalis: simultaneously used with glucocorticoid may increase the possibility of arrhythmia or toxicity of digitalis and hypotension.

Phenobarbital, Phenytoin, Rifampicin or Ephedrin may increase corticosteroid metabolism and reduce their treatment effects.

Patients who use both corticosteroids and estrogen must be monitored on the excessive effect of corticosteroids because estrogen may change the metabolism and protein bonding level of glucocorticoid, leading to reduced waste, increasing half -life, increasing treatment and toxicity of glucocorticoid.

The coordination effect of nonsteroidal or alcoholic anti -inflammatory drugs with glucocorticoids can lead to the tomb that occurs or increases the severity of the gastrointestinal ulcer. Corticosteroids may increase the concentration of salicylate in the blood. Must be cautious when used in combination with aspirin with corticosteroids in the case of reducing blood prothrombin.

Simultaneous use of Clobetasol propionat and other corticosteroids (oral, injection or nasal spray) easily increases the risk of glucocorticoid overdose leading to inhibition of hypothalamus - pituitary - adrenal glands.