Ventolin Nebules 2.5mg GSK solution treatment, prevent bronchospasm (6 blisters x 5 tubes)

Dosage form Box of 6 blisters x 5 tubes x 2.5ml
Specifications Salbutamol

Ingredient

Thành phần cho 2.5ml

Composition information	Content
Salbutamol	2.5mg

Uses

Indications

Ventolin Nebules 2.5mg is indicated in the following cases:

Salbutamol is a selected copper substance on the Adrenergic Beta2 receptor that is designated for treatment or prevention of bronchospasm. The drug has a short bronchodilator (4 hours) in the obstruction of the airway capable of recovery caused by asthma, chronic bronchitis and emphysema . For patients with asthma, Salbutamol can reduce symptoms when asthma attacks and prevention before known situations will start asthma attacks. For persistent asthma patients who do not respond to Ventolin, inhaled corticosteroids need to be treated to achieve and maintain control of non -response to Ventolin treatment may be a sign that patients need medical or emergency treatment.

Regular control of chronic bronchospasm - not responding to conventional treatment.

Acute severe asthma treatment (malignant asthma attack).

Pharmacy

Salbutamol is a selective agent on Adrenergic Beta2 receptor. With the dose of treatment, the drug has the effect on the Adrenergic Beta2 receptor of the bronchial muscle, causing the bronchodilator short (4 to 6 hours) along with a quick starting start (within 5 minutes) in the case of recovery airway obstruction.

pharmacokinetic

absorption

After using the inhaling line about 10 to 20% of the dose to reach the lower steaming hole. The rest is kept in aerosol equipment or deposited in the mouth of the pharynx, where the drug is swallowed. The deposits on the gas path are absorbed into the lung tissue and circulatory but not metabolized in the lungs.

Distribution

Salbutamol is connected to plasma proteins about 10%.

Metabolism

Until the whole body, Salbutamol is metabolized in the liver and is excreted mainly in the urine in a constant form and phenolic sulfate.

The swallowing part from the inhaled dose is absorbed from the gastrointestinal tract and is mostly converted into phenolic SUFAT.

Elimination

Noth the unmistakable drug of salbutamol and the bond (phenolic sulfate) are excreted mainly in the urine. A small part of the drug is excreted in stool. After taking a dose of inhaled Salbutamol, most of the amount of salbutamol is excreted within 72 hours.

Before taking Ventolin Nebules 2.5mg GSK solution treatment, prevent bronchospasm (6 blisters x 5 tubes)

How to use

inhaled form.

Dosage

Ventolin Nebules 2.5mg is prepared for use in non -diluted form. However, if you want to extend the drug distribution time (more than 10 minutes), you may need to be diluted with aseptic physiological saline.

Ventolin Nebules 2.5mg is used with a gas machine as instructed by a doctor.

Do not be injected or swallowed aerosol solution.

Using more and more beta owners can be a sign of severe asthma. In these cases, it is possible to conduct a re -evaluation of the patient's treatment regimen and consider combining treatment with Glucocorticosteroid.

Can use masks, T -tubes or through the internal intubation to distribute the drug. It is possible to use interrupted positive pressure ventilation but rarely necessary. Need for oxygen breathing when there is a risk of deficiency of oxygen due to ventilation.

When using too high dose can cause adverse effects, so it should only increase the dose or increase the frequency of use when prescribed by a doctor.

Due to many types of aerosol machine on the principle of continuous gas flow, the gas drug may be released into the surrounding environment. Therefore, it is advisable to use Ventolin Nebules 2.5mg in a room with good ventilation, especially in the hospital when many patients use the gas machine at the same space, at the same time.

salbutamol in the form of aerosol solution can be used on adults, adolescents and children 4 years of age and older.

Adults

The appropriate starting dose of Salbutamol aerosol solution is 2.5mg.

may increase the dose to 5mg. Can be used up to 4 times/day. When treating heavy gas pathway in adults, the dose may be higher, up to 40mg/day, under strict medical supervision at the hospital.

Children

Children 12 years and older: Dosage like adults.

Children from 4 - 11 years old: 2.5mg to 5mg to 4 times daily.

For children under 4 years old, other types of presentation of salbutamol may be more suitable.

Clinical effectiveness of gas ventolin in children under 18 months of age is not known clearly. Should consider using oxygen supplement therapy because there may be a lack of transient oxygen oxygen.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

There may be reduced hypotension after overdose of ventolin. Should check serum potassium concentration.

There have been reports on lactic acid infections related to high doses as well as overdose of beta -shaped copper, so in cases of overdose may need to monitor serum lactate increase and consequences of metabolic acidosis (especially if there is rapid breathing or worse even though there are no signs of other bronchial spasms such as wheezing).

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ventolin Nebules 2.5mg you may experience unwanted effects (ADR).

The unfavorable events listed below are classified by organ and frequency. The frequency is determined as follows: Very popular (> 1/10), popular (> 1/100 to 1/1,000 to 1/10,000 to

immune system disorders:

Very rare: Hypersensitivity reactions include angioedema, urticaria, bronchospasm, hypotension and vascular collapse.

Disorders of metabolism and nutrition:

Rare: Hypotension. Serious hypotension may be the result of the treatment of Beta 2.

Very rare: Lactic acidosis. Lactic acidosis has been reported very rare in patients treated with Salbutamol in intravenous or aerosol to treat acute asthma outbreaks.

Nervous system disorders:

Popular: Run, headache.

Very rare: increasing activity.

Heart disorders:

Popular: tachycardia.

Unpopular: Breaking the chest drum.

Very rare: arrhythmia includes atrial fibrillation, ventricular tachycardia and extras.

circuit disorders:

Rare: peripheral blood vessels.

Respiratory, chest and mediastinum disorders:

Very rare: paradoxical bronchospasm.

Gastrointestinal disorders:

Unpopular: throat and mouth irritation.

Musculoskeletal and connective tissue disorders:

Uncompleted: cramps.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ventolin Nebules 2.5mg contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when used

only use Ventolin Nebules 2.5mg by inhaling the mouth, not injected or swallowed.

In severe or unstable asthma patients should not only be treated or treated mainly with bronchodilators. Severe asthma patients should be evaluated regularly due to death. Severe asthma patients have continuous symptoms and frequent drama, with limited physical ability and PEF value of less than 60% of the initial prediction with a variable value of over 30%, often not returning completely after using bronchodilators. These patients need to be treated with high -dose corticosteroids (such as Beclomethason dipropionate> 1mg/day) or oral corticosteroids. Corticosteroid dose may be increased when symptoms deteriorate but must be conducted under the close supervision of a doctor.

Often, asthma should be controlled according to the steps and should monitor the response of patients clinically and by lung function tests.

Increasing the use of beta2 shipping owners inhaled inhalation to control symptoms indicates that asthma controls deteriorate. At that time, the patient treatment plan should be re -evaluated. Sudden and increased deterioration of asthma is a sign of life -threatening patients and should consider to start using or increasing corticosteroid dose. May need to check the daily flow of peaks in patients who are considered to be at risk.

warns that patients treated with Ventolin Nebules 2.5mg at home that if responded to a reduced drug or a decrease time time, do not increase the dose or increase the frequency of use but should consult a doctor.

Should use Ventolin Nebules 2.5mg cautious in patients who know how to use large dose of other anti -sympathetic drugs.

Should use Ventolin cautiously in patients with toxic thyroid.

may experience heart effects when using sympathetic drugs, including salbutamol. There are some evidence from data after circulation and literature about the occurrence of myocardial ischemia related to salbutamol but rare. Patients with severe heart disease (for example, ischemic heart disease, arrhythmia or severe heart failure) using salbutamol should be warned of medical examination if they have chest pain or other symptoms of heart disease progresses. Be careful when assessing symptoms such as shortness of breath or chest pain because those symptoms may have respiratory or cardiovascular origin.

There has been a report on acute angle glaucoma in a small number of patients using a combination of gas ventolin with ipratropium bromid. Therefore, be careful when using a combination of gas ventolin with other anti -cholinergic drugs. Should give adequate instructions on how to use properly and warn the patient must not leave the solution or dew in the eye.

The risk of severe hypokalemia may be the result of the treatment of beta2 agonized substance mainly by injection and aerosol. It is necessary to be careful especially for acute severe asthma because this side effect can increase when treated in combination with Xanthin, Steroid, Diuretics and Diver Diuretics and when lack of oxygen. Should monitor blood potassium in these cases.

As well as other inhaled treatments, paradoxical bronchospasm can appear, immediately increase the symptoms of wheezing after taking the drug. Should be treated immediately by other form of preparation or by a quick -inhaled bronchodilator if available. Should stop using Ventolin Nebules 2.5mg Nebules immediately and replace it with another quick -acting bronchodilator to use if needed.

Like other Beta adrenergic receptors, ventolin can cause changes in metabolic recovery, such as increased blood sugar levels.

Patients with diabetes may not compensate for these changes in metabolism and have reported on acidosis. This effect may increase when used with corticosteroids.

There has been a report of lactic acidosis but very rare, when using high doses of beta -shaped substances that shorter the aerosol and intravenous use, mainly in patients who are being treated for acute asthma plays (see unwanted effects). Increased lactate concentration can lead to shortness of breath and increased ventilation, which may be misunderstood as a sign of failure treatment and lead to an increase in the treatment of the Beta owner inappropriate effect. Therefore, patients should be monitored on increased serum lactate concentration and consequences of metabolic acidosis in this case.

The ability to drive and operate machinery

salbutamol has unwanted effects including: Run, headache and tachycardia. In addition, there may be undesirable effects such as cramps, brushing chest drums, increased activity, atrial fibrillation, ventricular tachycardia and collection. If the drug affects the ability to drive and operate machinery, then should not take the drug.

Pregnancy

should only consider using drugs during pregnancy when the benefits of treatment for the mother outperform the risk may be on the embryo.

During the world -world circulation, rarely reports on various congenital abnormalities, including spears and spas in the children of patients treated with salbutamol. Some of these mothers have used many different drugs during pregnancy.

Do not distinguish the consistent form of defects and the common rate of congenital abnormalities is 2 to 3%, so the relationship between salbutamol and deformities has not been determined

Breastfeeding period

Salbutamol can be excreted in breast milk, the use of drugs in nursing mothers is not recommended unless the expected treatment benefits for mothers surpasses any potential risk. It is unknown whether salbutamol in breast milk will cause adverse effects for babies.

Medicinal interaction

often should not prescribe ventolin for patients simultaneously with unsatisfactory beta blockers, like propranolol.

Non -contraindications for using ventolin for patients who are being treated with Monoamine inhibitors Oxidase (Maois).

Storage

Store no more than 30 oC. Nebules must be preserved to avoid light (by leaving the nebules in the aluminum tray stored in the box). Nebules tubes are not used after 3 months from opening aluminum blisters to be removed.

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