Verospiron 50mg Gedeon medicine for hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Spironolactone

Ingredient

Composition information	Content
Spironolactone	50mg

Uses

indications

Verospiron 50 mg is indicated in the following cases:

Treatment Hypertension . inappropriate.

Spironolacton is an antagonist competition with aldosteron. The drug acts on the renal tubules far away, inhibits the impact of water retention and na+, the exhaust effect of aldosteron. It not only increases the excretion of Na+, Cl-, reduces the excretion of K+ but also inhibits H+ excretion into the urine. The results of diuretic effects lead to hypotension.

pharmacokinetics

The absorption of spironolacton from the gastrointestinal tract is fast and strong. The drug is strongly connected to plasma proteins (about 90%).

Spironolacton is rapidly metabolized. The active metabolites with pharmacological effects are 7α-thiomethylspironolacton and canrenon. Despite the short selling time of Spironolacton (1.3 hours), the sale time of its active metabolites is longer (varies from 2.8 - 11.2 hours).

These metabolites are mainly excreted into the urine, a small amount into the feces. Spironolacton and metabolites through the placenta fence, and also in breast milk.

After using 100 mg of spironolacton daily for 15 days for volunteers in a constant state, the time of reaching the peak concentration in plasma (TMAX), the peak concentration of plasma (CMAX) and the waste sale time (T1/2) with Spironolacton is 2.6 hours, 80 ng/mL and approximately 1.4 hours. With metabolic 7α-Taomethylspironolacton and Canrenon Tmax are 3.2 hours and 4.3 hours; CMAX is 391 ng/ml and 181 ng/ml, and t 1/2 is 13.8 hours and 16.5 hours. The impact on the body of a single -dose of Spironolacton reaches the peak after 7 hours and its activity lasts for at least 24 hours.

Before taking Verospiron 50mg Gedeon medicine for hypertension (3 blisters x 10 tablets)

How to use

In general, the daily dose of Verospiron 50mg is used once a day or divided into 2 times, taking the drug after meals. Recommendations for daily dose or first dose of the day in the morning.

Dosage

primary Aldosteron has been diagnosed with

Take the oral dose of 100 - 400 mg daily to prepare for surgery. Patients who are not suitable for surgery, can be treated with long -term with Spironolacton at minimal doses that are effectively determined for each patient. In this case, the starting dose may be reduced every 14 days until the minimum dose is effective. During long -term treatment, it is recommended to use a combination of verospiron with other diuretics to minimize unwanted effects.

edema (congestive heart failure, kidney syndrome)

Adults: The normal starting dose is 100 mg (25 - 200 mg), used once or divided into 2 times.

When needed more efficient, can be combined with another diuretic that has an impact on the nearby tube. In this case should change the dose of verospiron.

cirrhosis is accompanied by ascites or edema

If the Na+/K+ urinary ratio is over 1.0: daily daily beam and daily dose is 100 mg.

If this ratio is less than 1.0: daily daily starting dose is 200 mg, the maximum dose is 400 mg/day. Determine the maintenance dose for each specific case.

Definitely hypertension

The starting dose is 50 - 100 mg/day, once used or divided into two times, used in combination with other anti -hypertension drugs. Treatment of Verospiron continuously for at least 2 weeks, because the maximum anti -hypertension effect can only be achieved after 2 weeks of treatment. Then, adjust the dose depending on the response of each patient.

Hemoto hypoassiasis

Normal daily dose is from 25 - 100 mg if it is impossible to provide K+ by oral or can not use other potassium keeping methods.

Children

Daily daily daily -dose is 1.0 - 3.0 mg/kg body weight or 2 times. The dose should be reduced from 1 - 2 mg/kg body weight in case of maintenance or in combination with other diuretics.

Elderly

Recommendations should start treatment with the lowest dose and increased dosage until the maximum efficiency is achieved. Caution should be careful with patients with liver failure or kidney failure because this condition can change the metabolism and excretion of the drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Sleep, mental disorders and change in test results.

If you overdose due to intentional or confusing, notify the doctor immediately or go to the emergency room of a nearest hospital for treatment.

Treatment:

Treatment of symptoms, no detoxifying antidote. Need to maintain water - electrolyte balance, acid -base balance, use diuretics loss potassium, glucose + intravenous insulin, in severe cases may have to cause blood decomposition.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Verospiron 50mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Metabolism: hyperkalemia (in patients with renal failure, people with diabetes and the elderly).

Endocrine: Big breasts in men, breast tightness and big breasts (in women), menstrual disorders, reduced fertility.

Cardiovascular: arrhythmia.

Neurological: Reduce sexual desire, Sexual disorders .

Digestive: Nausea, vomiting.

Uncommon, 1/1000

Neurology: Confusion, Sleeping, headache , weakness, fatigue.

Rare, 1/10,000

Gastrointestinal: gastritis, ulcers, stomach bleeding, abdominal pain, diarrhea.

Systemic: allergies (hypersensitivity), red skin, rash.

Metabolism: Reduce blood sodium, dehydration.

Hematology: Hemorrhagic disorders (haemoglobin disorders).

Very rare, ADR

Hematology: Disorders of hematopoietic disorders (increase or decrease some blood cell components).

Endocrinology: Collarism in women.

musculoskeletal muscles: muscle paralysis, abnormal in bone formation.

Skin and subcutaneous tissue: Eczema , heavy skin reaction.

Kidney - urinary: renal failure, changing test results (reducing blood urea).

Hepatitis: Hepatitis.

Other: Vascular inflammation, voice change, hair loss.

Unknown frequency

Metabolism: Acid-base imbalance.

Cardiovascular: Unwanted hypotension.

Instructions on how to handle ADR

Unwanted effects occur when using a Verospile capsule is usually mild and out after the drug stops.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Verospiron 50 mg contraindicated in the following cases:

Hypersensitivity (allergies) with Spironolacton or any ingredients of the drug. low).

Be cautious when using

patients must be examined and considered carefully before using Verospiron capsules in the following cases:

Liver disease.

Kidney disease.

Treatment with verospiron may affect serum concentration, cortisol and plasma epinephrin concentrations.

When using a Verospile capsule with foods and beverages: do not drink alcoholic beverages while using Verospiron, or during the time the drug is still effective.

Other important information about the composition of the Verospile capsule: Each capsule contains 127.5 mg of lactose monohydrate, which must be noted in case the patient is not tolerant to lactose.

The ability to drive and operate machinery

During the first time taking the drug, the patient was not allowed to drive, and avoiding dangerous jobs. After that, the doctor will determine the level of activity limit for each patient.

Pregnancy

contraindicated verospiron for pregnant women.

Breastfeeding period

Contraindications. If it is necessary to use Verospiron 50mg, stop breastfeeding and replace it with other foods.

Medicinal interaction

Precautions when used simultaneously with the drugs:

Salicylate (reducing diuretics). norepinephrin (Verospiron reduces the effect of this group). ) lithium). Hey).

Change test results:

Spironolacton can affect Digoxin radioactive quantification.

Storage

Store in a dry place, temperature below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.