Vertiko 24 Cadila treat dizziness, hearing loss (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Betahistine dihydrocloride

Ingredient

Composition information	Content
Betahistine dihydrocloride	24mg

Uses

indicated

Vertiko 24mg indicated for treatment in the following cases:

Treatment of ménière syndrome has been determined by the following three basic symptoms:

Dizziness (with nausea).

Pharmacokology

Betahistin's operation mechanism is not well known. There are some hypotheses given from animal and human studies.

The effect of betahistin on the histaminergic system (organs and nerves that neurotransmit is histamine):

Betahistin acts as a part of the H1 receptor and receptor antagonist H3 in the nerve tissue and does not have a significant effect on the H2 receptor. Blood to the snail area as well as the whole brain:

Animal pharmacological trials show that improving blood circulation in the blood vessel layer of the inner ear, possibly by relaxing the capillary sphincter of the microcirculation in the inside.

Betahistin accelerates the recovery of the vestibular after cutting the nerve on one side of the animal, by promoting and facilitating the central vestibular compensation, this effect is characterized by the increased air conditioner

metabolism and release of histamine, intermediaries through HG receptor resistance. Betahistin.

Betahistin also shows that the inhibitory effect depends on the dose on the tail of the nerve neuron in the side and the middle of the vestibular. Vestibular and ménière syndrome have been proven by improving the condition and frequency of dizziness.

pharmacokinetics

absorption:

Betahistin is easily absorbed and almost completely absorbed in all parts of the digestive system. Therefore, pharmacokinetic analysis is based on quantitative 2-paa in plasma and urine. However, the total volume of betahistin is equivalent to both states, showing that food only slows down the absorption process of betahistin.

Distribution:

Betahistin ratio is linked to plasma proteins below 5%.

After absorption, betahistin is quickly transformed and almost completely into 2-paa (without pharmacological effects).

2-Paa quickly excreted through the urine. At the dose of 8 - 48 mg, about 85% of the dose detected in the urine.

The recovery speed is the constant in the dose of 8 - 48 mg shows that the pharmacokinetics of Betahistin is linear, and shows that the metabolic path is not saturated.

Before taking Vertiko 24 Cadila treat dizziness, hearing loss (10 blisters x 10 tablets)

How to use

Vertiko 24mg Tablets Tablets for oral. Should take medicine after meals.

Dosage

Adults (including the elderly):

Dosage recommended: Taking doses of 24 - 48 mg divided into several times a day (1-2 capsules 3 times/day).

The doctor will adjust the dose based on the patient's response. Symptoms will be improved after 2 weeks of taking the drug, the best results are only achieved after a few months.

Betahistin is not recommended for children under 18 years of age because there is no enough data on safety and efficiency.

What to do when overdose?

Some patients experience mild to medium symptoms such as nausea, vomiting, drowsiness and abdominal doses when taking doses to 640 mg. Support.

What to do when you forget 1 dose? However, if the time of relaxation with the next dose is too short, skip the forgotten dose.

Side Effects

The following unwanted effects are studied with the frequency specified in patients treated with betahistin in placebo clinical tests: very common (≥1/10), or encounter (≥1/100, Gastrointestinal disorders:

common: Nausea and indigestion.

Nervous system disorders:

Common: headache

Additional to the events that have been reported in clinical trials, unwanted effects after being reported voluntarily during use after circulation and in specific materials. The frequency cannot be estimated from available data and therefore classified as "unknown".

immune system disorders:

Sensitive reaction, for example, anaphylactic reaction has been reported.

Gastrointestinal disorders:

Mild stomach pain (for example, vomiting, stomach pain, bloating and flatulence).

Some sensitive reactions in the skin and subcutaneous skin have been reported, specifically nerve angiema, urticaria, rash and itching.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vertiko 24mg Contraindicated in the following cases:

Do not use drugs if allergic (hypersensitivity) with betahistin or any ingredients of the drug or if adrenal tumors.

Be cautious when using

betahistin is considered unsafe for patients with porphyrin metabolic disorders.

Be cautious in patients with stomach - duodenal ulcer or have a history of stomach - duodenal ulcer.

It has seen clinical intolerance in bronchial asthma patients. Need to closely monitor these patients during treatment.

affects the ability to drive and operate machinery

Ménière syndrome with symptoms of dizziness, tinnitus, hearing loss that affects the ability to drive and operate machinery.

Betahistin has an unwanted effect that is a headache, need to be cautious when driving and operating machinery.

Pregnant and lactating women

Pregnant women:

There is no adequate data related to the use of betahistin in pregnant women. Betahistin during pregnancy, unless the doctor is necessary.

Breastfeeding period:

It is unclear the excretion of Betahistin through breast milk. The risk of breastfeeding.

Interactive drug

There has been no interaction studies on the living body (in vivo) conducted. The data is based on the laboratory (in vitro) does not notice that there is inhibition of cytochrom P450 enzymes on the basis of living.

If the patient is taking Mono-Amine-Oxidase inhibitors (Maois, including sub-crests B (e.g. Selegiline)), the drug is used to treat depression or Parkinson, patients should notify the doctor because these drugs can increase the effect of betahistin.

Betahistin has the same structure as histamine, drug interaction between betahistin and antihistamine can affect the effectiveness of one of these drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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