Viagra 50mg viatris medicine for erectile dysfunction (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Sildenafil

Ingredient

Composition informationContent
Sildenafil50mg

Uses

indications

viagra medicine is indicated in the following cases:

  • Treatment of erectile dysfunction, which is the inability to achieve or maintain an erection enough to satisfy sexual activity. Sex. Then NO activated the Ganylat Cyclase yeast, this enzyme increases the concentration of CGMP, thereby relaxing the blood vessel smooth muscle of the cave and allows the blood flow to flow.

    Sildenafil has no direct relaxation effect on human isolation, but it increases the effect of NO by inhibiting PDE5, this substance has the effect of decomposing CGMP in the cave.

    When stimulating sex, creating a NO release on the spot, Sildenafil's PDE5 inhibitors will increase the amount of CGMP in the cave, the result of smooth muscle relaxation and increase blood flow to the cave.

    In the recommended dose, Sildenafil only works when there is an accompanying sexual stimulation.

    Dynamic pharmacokinetics

    corresponding to the dose in the recommended dose range.

    absorption:

    Sildenafil is quickly absorbed after drinking, with bioavailability of about 41%. The maximum concentration achieved in plasma from 30-120 minutes.

    Distribution:

    Sildenafil's average drug distribution (VSS) is 105 l, which focuses on tissues. Attach up to 96% to plasma proteins.

    Metabolism:

    Sildenafil is metabolized mainly by CYP3A4 (main roads) and CYP2C9 (sub -line) in the liver.

    Era:

    Sildenafil's total clearance is 41 l/h with the last half phase time of 3-5 hours.

    After oral or intravenous use, Sildenafil is excreted mainly in the form of metabolites (about 80% of oral doses) and a small part of urine (about 13% of oral dose).

    • Before taking Viagra 50mg viatris medicine for erectile dysfunction (1 blister x 4 tablets)

    How to use

    Sildenafil tablets are used by oral, orally before having sex about 1 hour.

    Dosage

    Adults

    Most patients are recommended to take the dose of 50 mg when needed.

    Based on the tolerance and effect of the drug, the dose may increase to a maximum of 100 mg or decrease to 25 mg. The maximum recommended dose is 100 mg, the maximum number of times is 1 time per day.

    Children:

    Do not use Sildenafil for people under 18 years old.

    For the elderly

    No need to adjust the dose.

    For patients with renal failure

    Cases of mild or medium renal failure (Creatinine clearance = 30-80 ml/min), do not need to adjust the dose.

    Cases of severe renal failure (Creatinine clearance

    For patients with liver failure

    The dose to be used is 25 mg because the clearance of Sildenafil is reduced in these patients (for example, cirrhosis).

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    In case of an overdose, requires appropriate support measures. Kidney fertilizer does not increase the clearance because Sildenafil is strongly attached to plasma proteins and is not eliminated through the urine.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using viagra medicine , you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Neurological: headache, dizziness ;
  • Eyes: blurred vision, disorder, evidence of green;
  • Blood vessels: hot, flushing;
    • Respiratory: stuffy nose; digestive: nausea, indigestion.

    Uncommon, 1/1000

  • Infection: rhinitis;
    • immunity: hypersensitivity; Neurology: Sleep;
  • Eyes: eye pain, fear of light, dizziness, dysliafish, eye congestion, dazzling;
    • Heart: tachycardia, chest drumming; blood vessel: Hypotenema;
  • Respiratory: nosebleeds, sinus switches;

    • digestion: gastroesophageal reflux esophagus, vomiting, epigastric pain, dry mouth ; Other disorders: muscle pain, headache, rash, hot feeling at the genitals.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    viagra medicine contraindicated in the following cases:

  • Contraindicated use of Sildenafil for patients allergies to any ingredients of the drug.
  • Contraindicated use of Sildenafil for patients who are using nitric oxidation suppliers, organic nitrates or organic nitrides.
  • Contraindicated use of PDE5 inhibitors, including Sildenafil, with Ganylate Cyclase stimulants, such as riociguat.

    • Not used for women.

    Be cautious when using

    because there may be some cardiovascular risks related to sexual activity, so pay attention to the patient's cardiovascular condition before the treatment of erectile dysfunction.

    Do not use erectile dysfunction drugs in men are recommended not to be sexually active.

    Patients who hinder the left ventricular flow (for example, aortic stenosis, obstructive hypertrophy) or a multi -system syndrome of multiple systems atrophy are patients with hyperactive hyperplasia, those who need to be very considerate when treated.

    Be cautious when treating Sildenafil in patients with a history of cardiovascular risk factors, pigmentitis, coagulation disorders or acute digestive ulcers, penile anatomical deformation (such as angular folding penis, caves fibrosis, or Peyronie disease), penis disease (such as sickle blood cell anemia, hypercellinal disease)

    The ability to drive and operate machinery

    There is no specific research on the effects of driving and operating machinery.

    Dizziness and vision change have been reported in clinical trials with Sildenafil, so patients need to know how they react to Sildenafil before driving or operating machinery.

    Pregnancy

    Do not use Sildenafil for pregnant women.

    The period of breastfeeding

    There are no complete and appropriate studies in breastfeeding women. Do not use sildenafil for breastfeeding women.

    Interactive drug

    The effect of other drugs on Sildenafil

    All agents that inhibit the groups of cytochrom P450 (CYP) form 3a4 (main road) and 2C9 (auxiliary road) can reduce the clearance of Sildenafil and other stimulating agents that can increase Sildenafil's clearance.

    In vivo studies:

  • When using Sildenafil simultaneously with CYP3A4 inhibiting agents (such as ketoconazole , erythromycin, cimetidin) will reduce the clearance of Sildenafil. Healthy volunteers.
  • simultaneously used a single dose of 100 mg Sildenafil with the protease inhibitor of HIV saquinavir (1200 mg used 3 times/day), increasing Sildenafil's CMAX to 140% and increasing AUC to 210%. Sildenafil does not affect the pharmacokinetics of Saquinavir. Concentrated with strong CYP3A4 induction substances, like rifampin, is expected to reduce sildenafil levels in plasma.
  • CYP2C9 inhibitors (such as Tolbutamid, Warfarin ), CYP2D6 inhibitors (such as Serotonin -selective reactors, 3 -round antidepressants), Thiniazid, angiotensin (ACE) enzyme inhibitors (ACE) and calcium channel blockers do not affect the pharmacology Sildenafil.

    • Sildenafil's influence on other drugs

    In vivo studies:

  • Do not use Sildenafil along with substances for nitric oxidation, organic nitrates or organic nitrite. Sildenafil (50 mg) with Tolbutamid (250 mg) or Warfarin (40 mg). Aspirin (150 mg).
    •

    Storage

    Store at a temperature not exceeding 300C.

    Other drugs

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