Vicetin 10mg Sopharma drugs treat vascular disorders, blood circulation disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Vinpocetine

Ingredient

Composition information	Content
Vinpocetine	100mg

Uses

indicated

Treatment of various forms of brain blood circulation disorders: post -mutated condition, dementia with a cause of vasoconstriction, atherosclerosis, post -traumatic brain disease and hypertension, degeneration of the background system. The drug reduces mental symptoms due to cerebral circulatory disorders. N06BX18
Vinpocetin is a substance with a complex impact mechanism. The drug has a favorable effect on the metabolism in the brain and blood flow, as well as the characteristics of blood flow. Na+ and Ca2+ inhibitors depend on voltage as well as NMDA and AMPA receptors. The drug enhances the nerve protection effect of adenosine. increase tolerance with oxygen deficiency of brain cells; Increase glucose transport - the only source of energy of the brain - through the brain barrier; direct the transformation of glucose to the aerobic cycle more favorable in terms of energy; Selective inhibition of CGMP-GHOSPHODIesterase (PDE) depends on Caalmodulin; Increase the Camp and CGMP levels in the brain. The drug increases ATP concentration and ATP/AMP ratio; increased the flow of norepinephrin and serotonin of the brain; stimulating the noradrenegic system upwards; The drug has an antioxidant effect. The results of all of the above effects help Vinpocetin have the effect of protecting the brain. reduce the increase in pathological blood viscosity; increase the deformation of red blood cells and inhibit the acquisition of adenosin of red blood cells; Increasing oxygen transport into brain tissue by reducing oxygen affinity with red blood cells. Reducing brain -resistant resistance without affecting the parameters of the whole body (blood pressure, cardiac supply, heart rate, total peripheral resistance); Does not cause blood appropriation. In addition, during the treatment period, it also increases blood supply for the brain area (but not necrotic) is low (inversely acting with blood appropriation).

pharmacokinetics

absorption:

Vinpocetin is quickly absorbed, the peak concentration in plasma reaches 1 hour after drinking. The absorption position is the upper part of the gastrointestinal tract. The drug is not metabolized when passing through the intestinal wall.

Distribution:

In humans, Vinpocetin binds to plasma proteins of 66%. Vinpocetin's absolute oral bioavailability is 7%. The distribution volume is 246.7 ± 88.51. Vinpocetin clearance value (66.7 l/hour) exceeds the liver's plasma value (50 l/hour), indicating the metabolism of the liver.

Metabolism:

The main metabolites of Vinpocetin are Apovincamin acid (AVA) accounting for about 25-30% when used for humans. After drinking, the area under the curve of AVA is twice as large as the intravenous injection indicates the AVA production in the first transformation phase. The further metabolites are identified as hydroxyvinpocetin, hydroxyl-ava, dihydroxy-ava glycinat and their complexes glucuronid and/or sulphate. Among the research species, the amount of Vinpocetin is excreted into the urine in the form of unchanged limbs and the percentage of the dose.

Elimination:

While the dose is repeated with 5 mg and 10 mg dose, Vinpocetin shows blood dynamics: Stable plasma concentration is 1.2 ± 0.27 ng/ml and 2.1 ± 0.33 ng/ml, according to the corresponding appropriate. The sale time is 4.83 ± 1.29 hours. In studies conducted with radioactive active ingredients, the main excretion path is through urine and fertilizer at 60-40%.

An important and preeminent feature of Vinpocetin is that there is no need to adjust the dose when used for liver or kidney disease because the drug does not accumulate.

Studies show that Vinpocetin pharmacokinetics in the elderly are not big compared to young people, without increasing accumulation.

Before taking Vicetin 10mg Sopharma drugs treat vascular disorders, blood circulation disorders (3 blisters x 10 tablets)

How to use

take medicine after meals.

Dosage

Take 1 capsule/time x 3 times/day. Maximum dose of 3 capsules /day.

For patients with renal failure, liver failure: no dose adjustment.

What to do when overdose?

Overdose: There is no report on overdose of Vinpocetin.What do you do when you forget a dose? However, if you are close to the next dose time, you should skip the forgotten dose and continue to use according to the normal course.

Side Effects

Vinpocetin can cause the following unwanted effects:

Sometimes occurs: nausea, dry mouth, abdominal instability, hot feeling, hypotension, headache, dizziness, dizziness, drowsiness, excitement. Enlightenment, increase mental activities, sleep disorders, insomnia, agitation, restlessness, itching, increased sweating, urticaria,
rash, hypertension, redness.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Patients with hypersensitivity to any component of the drug.

Pregnant and lactating women, children.

Caution when using

should be cautious when used in patients with blood pressure loss drugs, as well as patients with low blood pressure or posture hypotension and liver damage patients.
Products containing lactose, should not be used for people with Galact

The effect of the drug on the ability to drive and operate machinery

vinpocetin can cause headaches, dizziness, drowsiness so be careful for operators, train drivers, higher people working and other cases.

Using drugs for women during pregnancy and lactation

Pregnancy:

Do not use this drug during pregnancy.

Breastfeeding period:

Do not use this medication during breastfeeding.

Drug interaction

When taking Vinpocetin with beta blockers such as chloranolol and pinkolol, with Clopamid, Glibenclamid, Digoxin, Acenocoumarol or Hydrochlorothiazid, no drug interactions. Alphamethyl-Dopa, so it is necessary to check blood pressure regularly when used in combination with this drug. Although clinical data does not show interactions, it is also necessary to be cautious when using a combination of Vinpocetin with medications on central nervous system, anticoagulant drugs, arrhythmia.

Storage

In a dry place, temperatures below 30 ° C.

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