Vicometrim 960 Vidipha treatment and prevention of pneumonia (10 blisters x 10 tablets)

The replacement of the standard doses by short -term treatment lasts from 1-3 days for the uncomplicated urinary tract infection, which has been shown to be effective.

Elderly patients

See the "cautious use" section. Unless the dosage is applied.

Liver function impairment

There is no research data related to patient dosage liver function impairment .

Special dose recommendations: (When applying other standard doses)

The case of indicated dosage used "tablets" is a suitable tablet for adults, for example 80mg trimethoprim and 400mg sulfamethoxazol. The appropriate dose should be adjusted if used in other dosage formats.

impaired renal function in adults and children over 12 years old (no information for patients under 12 years old):

Pneumocystis Jiroveci (P.Carinii):

Preventive: Adults: Can use the following procedures:

Nocardiosis

There is no agreement on the most appropriate dosage. Adults take a dose of 6 to 8 capsules daily for 3 months.

toxoplasmosis

No consensus and the most appropriate dosage to treat or prevent this disease. The decision should be based on clinical experience. However, for preventive prophylaxis, Pneumocystis Jiroveci can be used.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

How to deal with overdose:

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Patients with severe renal impairment, can not perform repeated measurements in plasma.

Precautions when used

sulfamethoxazol and trimethoprim are combined in the formula due to the synergistic effect. However, this combination causes unwanted but serious effects such as Steven-Johnson syndrome and reduces all bloody hemoglobin, especially osteomomalia and granulocytes, especially common in the elderly.

Avoid use for people with blood disorders (except for special monitoring), check the blood formula when treated for a long time, stop using immediately if blood disorders or foreign rash occurs.

Patients are at risk of folat deficiency or hyperkalemia.

Elderly.

asthma.

People deficiency G6PD.

impaired liver function (avoid use if serious decline).

Renal function decreases (avoid use if creatinine clearance is below 15m/minute).

Monitor patients when using herbs containing excipients with castor oil can cause abdominal pain and diarrhea.

The ability to drive and operate machinery

There has been no research to survey the effect of the drug on driving or operating machinery. Moreover, it is impossible to predict adverse effects on such activities from the pharmacological properties of the drug. However, it should be noted that the clinical condition of the patient and the unwanted effects of the drug when considering the ability to operate the patient's machines.

Pregnancy

trimethoprim and sulfamethoxazol through the placenta and the safety of drugs in pregnant women have not been established. Tracking and monitoring studies have shown that there may be a link between exposure to folat and birth defects in humans.

Trimethoprim is a folat antagonist and in animal studies, both agents have been shown to cause fetal abnormalities. Do not use drugs during pregnancy, especially in the first three months, unless necessary. Consider adding folat if using Vicometrim 960 during pregnancy.

sulfamethoxazol competes with bilirubin to link with plasma albumin. Because the concentration of drugs from the mother continues to exist for a few days in newborns, there may be a risk of precipitation or exacerbating the newborn bilirubin bilirubin, with the theoretical risk of the brain skin, when Viometrim 960 is used for mothers near the time of birth. This theoretical risk is particularly related to newborn babies who are at high risk of increased blood bilirubin, such as premature babies and people with glucose-6-phosphate dehydrogenase deficiencies.

Breastfeeding period

The components of Vicometrim 960 (trimethoprim and sulfamethoxazol) are excreted in breast milk. Vicometrim 960 should be avoided at the end of pregnancy and in nursing mothers, which newborns or babies have or have the risk of developing, increasing blood bilirubin. In addition, Vermoetrim 960 should be avoided in children under 8 weeks according to the concept of newborn babies with hyperlirubin blood.

Medicinal interaction

With laboratory tests, Trimethoprim may interfere with plasma/serum creatinine when using alkaline picrat reactions. This can lead to plasma/serum creatinine evaluation. Creatinine clearance decreases: Creatinine secretion in renal tubules decreased from 23% to 9% while glomerular filtration remains unchanged.

Zidovudin: In some cases, simultaneous treatment with zidovudin may increase the risk of unwanted and hematological effects of Vicometrim 960.

cyclosporin: The impaired renal function has been observed in patients treated simultaneously with cyclosporin after kidney implant.

Rifampicin: Concomitant use with rifampicin reduces the half -life of trimethoprim plasma after about a week. This has no clinical significance. When trimethoprim is simultaneously used with drugs forming cations in the physiological pH and is also partially excreted by the excretory activity of the kidney (e.g. Procanamid, Amantadin), the competition inhibitor ability of this process can increase the concentration of plasma of one or both drugs.

Diuretics (thiazid): In elderly patients, simultaneously used with diuretics, mainly thiazid, there is a risk of thrombocytopenia with or without hemorrhage.

pyrimethamine: Very few reports that patients taking pyrimethamine are higher than 25mg per week may have huge red blood cell anemia, so they are prescribed simultaneously with this combined antibiotic.

Warfarin: The drug increases the anticoagulant activity of warfarin through the selective inhibition of stereoscopic of metabolism. Sulfamethoxazol can remove warfarin from the albumin protein bonds in vitro. Caution should be cautious about anticoagulants during treatment with Vicometrim 960.

Phenytoin: The drug extends the selling time of phenytoin and if used simultaneously can lead to an increase in excessive phenytoin effect. Need to closely monitor patient condition and serum phenytoin concentration.

Digoxin: Using trimethoprim simultaneously with digoxin has increased plasma digoxin concentrations in some elderly patients.

Methotrexate: The drug may increase the concentration of free methotrexate in plasma. If you look at Vicometrim 960 as an appropriate treatment in patients with other anti -folat drugs such as methotrexate, it is advisable to consider adding folats (see carefully when used). Trimethoprim hinder plasma methotrexate quantification when using dihydrofolate reductase from lactobacillus casei in the test. There is no obstruction if measuring methotrexate by radioactive test.

lamivudin: Use trimethoprim/sulfamethoxazol 160mg/800mg increases 40% in contact with lamivudin because of trimethoprim composition. Lamivudin does not affect the pharmacokinetics of trimethoprim or sulfamethoxazol.

Interaction with sulphonylurea hypoglycemic drugs is not common but there has been a report on increased effects.

Hemorrhage hyperpass: When taking medications for patients who are taking drugs that can cause hyperkalemia.

Repaglinid: Trimethoprim may increase the contact of repaglinid, which can lead to hypoglycemia.

Folinic Acid: Folinic acid supplements affect the antibacterial effect of trimethoprim-sulfamethoxazol. This has been observed in the prevention and treatment of pneumes caused by Pneumocystis Jiroveci.

Birth control: Oral contraceptives are inactive because antibiotics have been reported. It is unclear this effect. Women treated with antibiotics should temporarily use other preventive methods other than oral contraceptives or choose other contraceptive methods.