Victoria 1.5mg Babiophar medicine is used for emergency contraception, used within 72 hours after intercourse (1 tablet)

With the recommended regimen, it is thought that Levonorgestrel mainly works by preventing ovulation and fertilization if the intercourse occurs in the phase of ovulation, which is the time when the highest possibility of conception. The drug can also cause endometriosis changes, hindering the nest of zygote. The drug does not work once the nest has begun.

Effective: Estimated, levonorgestrel prevents 84% ​​of expected pregnancy cases. According to the recommended regimen, levonorgestrel does not cause a significant addition of blood clots, lipid metabolism and carbohydrate.

Dynamic pharmacokinetics

Used by oral, levonorgestrel is absorbed quickly and almost completely.

Results of pharmacokinetics studies conducted on 16 healthy women show that, after taking a dose of 1 levonorgestrel tablet, the maximum concentration in the serum is reached at 18.5 ng/mL after 2 hours. The average value of the area under the concentration - time curve (0 -vo) is calculated about 310182.56 PG.H/ml. After reaching the maximum of the serum, the concentration of levonorgestrel decreases with an average selling time of about 26 hours.

levonorgestrel is not excreted in the form of unchanged but in the form of metabolites. The metabolites of levonorgestrel are excreted in feces and urine with the same ratio. The biological transformation takes place in the known way for the metabolism of steroids: levonorgestrel is hydroxy in the liver and metabolites excreted in the form of glucuronid.

No metabolites are found to be biological activity.

levonorgestrel is connected to serum albumin and globulin complex bonding sex hormones (SHBG). Only about 1.5% of the total serum concentration is present in the form of free steroids, while 65% specialized in SHBG.

After taking a levonorgestrel, the average value of SHBG is about 40 nmol/l. SHBG's serum concentration tends to hold this level (or slightly increased) for 24 hours, and then decreases to about 30 nmol/l after 192 hours.The absolute bioavailability of Levonorgestrel is identified as nearly 100% of the dose.

About 0.1 % dose for mothers can get milk to breastfeed.

Clinical properties: There is no research document.

Notify the physician with unwanted effects when using the drug.

Be cautious when using

Please see more information about the drug in the instruction sheet of the use of the drug attached.

Spreading and cautious scene when using the drug:

Emergency contraception is a passive contraception, only for "emergency conditions". Do not use this method instead of other conventional contraceptives.

Emergency contraception does not prevent pregnancy in any situation. If there is no certainty of the time of intercourse without contraception, or if a woman had sex without using a previous contraception for more than 72 hours but in the same period, she could still get pregnant. Therefore, using levonorgestrel after the second intercourse may not be effective. If menstruation more than 5 days, abnormal hemorrhage during menstruation or suspicion of pregnancy or any other doubt, it is necessary to visit to eliminate the possibility of pregnancy.

If pregnant occurs after using levonorgestrel, it is necessary to consider the possibility of ectopic pregnancy, especially for those who have abdominal pain in the pelvis or collapse, people with a history of ectopic pregnancy, fallopian tube surgery, pelvic disease.

In people with severe absorption syndrome like in Crohn's disease, the effect of levonorgestrel may decrease.

After using levonorgestrel, most menstrual cases are still normal and right. Some cases have menstruation earlier or a few days later. Doctors should advise those who have used levonorgestrel on the application of an appropriate method of contraception. If you have taken emergency contraception while taking other regular contraceptives that contain hormones, without menstruating at the time of taking a pills, it is necessary to visit to eliminate the possibility of pregnancy.

Do not use levonorgestrel with a repeated dose in the same menstrual cycle, as it can cause menstrual disorders.

The effect of levonorgestrel is not as high as other regular contraception, and is only suitable for emergency contraception purposes. For women who tend to re -use emergency contraception, it is necessary to recommend long -term contraceptive measures.

Using emergency contraception does not replace other cautious measures to prevent sexually transmitted diseases.

Precautions: levonorgestrel must be used carefully for epilepsy, valve disease, cerebral circulatory disease, and for people with an increase in the risk of ectopic pregnancy and diabetes. Levonorgestrel can cause fluid stasis, so when prescribing levonorgestrel must be carefully monitored in asthma, edema.

The effect of drugs on driving and operating machinery

There is no research on the effect of the drug on the ability to drive and operate the machine.

Use drugs for women during pregnancy and lactation

Follow the prescription from the doctor. The drug should only be used when the benefits are out of risks.

Drug interactions

Metabolism of levonorgestrel increases when using simultaneously levonorgestrel with liver enzyme induction drugs, mostly enzyme induction drugs CYP3A4. At the same time, using Efavirenz with levonorgestrel reduces the level of levonorgestrel in plasma by about 50%.

Other drugs suspected to reduce the same level of Levonorgestrel in plasma including barbiturat derivatives (including primidon), phenytoin, carbamazepin, drugs of medicinal origin with hypericum Perforatum (St. John's Wort), Rifampicin, Ritonavir, Rifabutin and Griseofulin. Women who have used enzyme induction drugs for 4 weeks earlier, use emergency contraception is a method of contraception without hormones (for example, placing an IUD in the uterus). For women who cannot or are not ready to place an IUD in the uterus, can take double the dose of levonorgestrei (ie 3000 micrograms within 72 hours after unsafe intercourse). However, the coordination of double -dose levonorgestrel and enzyme induction has not been fully studied.

Concentrated use of antibiotics can reduce the effects of the drug, due to intervention in the intestinal bacteria.