Vidaloxin phase powder 250mg Vidipha treats upper respiratory tract bacteria (20 packs)

Dosage form Box of 20 packs
Specifications Amoxicillin

Ingredient

Composition information	Content
Amoxicillin	250mg

Uses

indicated

upper respiratory infections.

Lower respiratory infections due to streptococcal, pneumococcal, non -secretic staphylococcus aureus and H. Influenzae.

Inhabited urinary tract infections.

Gonorrhea.

Bile infection.

Skin infections, muscles due to streptococcus, staphylococcus aureus, E. coli sensitive to amoxicillin.

Pharmacokology

amoxicillin is aminopenicilin, durable in acidic environment, has a wider spectrum than benzylpenicilin, especially anti -bacteria. Similar to other penicillins, amoxicillin has a bactericidal effect, due to inhibition of mucopeptide biosynthesis of bacterial cell walls. In vitro, amoxicillin is active with the majority of Gram -negative and Gram -positive bacteria such as: streptococcal, staphylococcus aureus without penicillinase, H. Influenzae, diplococcus pneumoniae, N. Gonorrheae, E. Coliva Proteus Mirabilis. Like ampicilin, amoxicillin is not active with penicillinase secretion, especially staphylococcus aureus, all Pseudomonas strains and most of the Klebsiella and Enorobacter strains.

Amoxicillin has a stronger printing effect than ampicilin for Enterococcus Faecalis and Salmonella spp., but less effective for Shigella spp. The spectrum of amoxicillin may be wider when used simultaneously with sulbactam and clavulanic acid, a beta - lactamase inhibitor. There has been a notice of E. coli resistant to amoxicillin in combination with clavulanic acid (16.8%).

According to the announcement No. 2 and No. 3 of the National Monitoring Program on the drug resistance situation of common pathogenic bacteria (ASTS), the level of ampicillin resistance of E. Coli is 66.7%, Salmonella Typhi is 50%, Shigella is 57.7%, acinetobacter spp. As 70.7%, other intestinal bacteria (Citrobacter, Entobacter, Klebsiella, Morganella, Proteus, Serratia, ..) are 84.1%, Streptococcus spp. is 15.4%, of the Enterococcus spp strains. is 13.1% and other Gram -negative bacilli strains (Achromobacter, Charymonas, Flavobacterium, Pasteurella, ...) are 66.7%.

Pharmacokinetics

absorption

Amoxicillin is sustainable in gastric acid environment. Absorption is not affected by food, faster and more completely through the digestive tract than ampicilin. When taken at the same dose like ampicillin, the concentration of amoxicillin peak in plasma is at least 2 times higher.

Distribution

Amoxicillin is quickly distributed into most tissues and fluids in the body, except for brain tissue and cerebrospinal fluid, but when the meninges are inflamed, amoxicillin is easily diffused. After taking the dose of 250mg amoxicillin 1 - 2 hours, the concentration of amoxicillin in the blood reaches about 4-5 micrograms/ml. Double tents can doubling blood concentrations in the blood. Amoxicillin's half -life is about 61.3 minutes, longer in infants and the elderly. In people with kidney failure, the half -life of the drug is about 7-20 hours long.

Elimination

About 60% of the amoxicillin dosage is excreted in the urine for 6-8 hours. Probenecid extends the waste time of amoxicillin through the kidney. Amoxicillin has high concentrations in bile fluid and a part of feces.

Before taking Vidaloxin phase powder 250mg Vidipha treats upper respiratory tract bacteria (20 packs)

How to use

oral medication.

Dosage

Adults:

Usually use 250mg - 500mg, 3 times/day.

Children under 10 years old:

125 - 250mg, 3 times/day.

Children under 20 kg:

20 - 40 mg/kg/day.

Children 3 - 10 years old otitis media:

If necessary, the dose of 750 mg/time can be used, 2 times daily, for 2 days.

For people with renal failure:

Must reduce the dose according to creatinine clearance coefficient:

CLCR

CICR> 10 ml/minute: 500 mg/12 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Management: Control of electrolyte balance in case of symptoms of stomach -intestinal disorders.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Skin and soft tissue: BOB (3 - 10%), usually appear slowly, after 7 days of treatment.

Uncommon, 1/1000

Digestive: Nausea, vomiting, diarrhea.

Hypersensitivity reactions: Red rash, rash and urticaria, especially Stevens - Johnson syndrome.

Rare, ADR

Liver: slight increase SGOT.

Central nerve: agitation, struggle, anxiety, insomnia, confusion, behavior change and/or dizziness.

blood and lymphatic system: Anemia, thrombocytopenia, thrombocytopenia, leukemia, eosin, leukopenia, granulocytosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Patients with allergies to B-lactam antibiotics.

Be cautious when using

periodically check the liver and kidney function during long -term treatment.

Severe hypersensitivity reactions in patients with allergies with penicillin or other allergens.

Allergic reactions such as erythema, edema, anaphylaxis, Stevens - Johnson syndrome.

The ability to drive and operate machinery

No report.

pregnancy

Amoxicillin safely used during pregnancy has not been clearly defined. Therefore, only this drug is needed during pregnancy. However, there is no evidence of harmful effects for the fetus when using amoxicillin for pregnant women.

Lactation period

Because amoxicillin is excreted in breast milk, it is necessary to be cautious when taking the drug during breastfeeding.

Medicinal interaction

Absorbing amoxicillin is not affected by food in the stomach, so it can be taken before or after meals.

nifedipine increases amoxicillin absorption.

When taken with alopurinol, increases amoxicillin's ability.

There may be antagonists between amoxicillin and bactericidal substances such as chloramphenicol, tetracyclin.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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