Vidipha calcium chloride injection solution treats convulsions, laryngeal spasms caused by lowering blood calcium (100 tubes x 5ml)

Dosage form Box of 100 tubes x 5ml
Specifications Calcium chloride dihydrate
Ingredient Hypergenia, hypocalcemia, hyperkalemia

Ingredient

Thành phần cho 5ml

Composition information	Content
Calcium chloride dihydrate	0.5g

Uses

Indications

Calcicloride 5 ml is indicated in the following cases:

Treatment of cases of rapid increase in blood calcium ionic concentration such as: convulsions due to lowering blood calcium in newborn babies, laryngeal spasms due to hypocalcemia, thyroid underpepant with tetani, hypaceau blood calcium due to re -mineralization; after hyperthyroidism surgery; Lowering blood calcium due to vitamin D deficiency, alkaline infection. After a large amount of blood transfusion contains calcium citrate causing blood calcium loss.

In case of hyperkalemia, to reduce the effect of inhibiting the heart, manifesting on the electrocardiogram.

In case of increased blood magnesium, calcium chloride is also used for the purpose of treating the effects of inhibiting the central nervous system when using the overdose of Magnesi Sulfate.

Overdose due to calcium blockers, poisoning due to ethylen glycol. Again in extracellular fluid, and a very small number in the cell.

In human plasma, calcium concentration is about 8.5 mg to 10.4 mg/decilite (2.1 - 2.6 mmol) of which about 45% are attached to plasma proteins, mainly albumin and about 10% complex with anionic buffer (such as citrate and phosphate). The rest is calcium ionization (Ca ++).

Ca ++ is essential for many biological processes: neuron stimulation, release of neurotransmitters, muscle contraction, preservation of membranes and coagulation. Ca ++ also helps the secondary communication function for the activity of many hormones.

On the cardiovascular system: Calcium ion is essential for stimulating and contracting myocardial muscle as well as for electrical impulse transmission on some areas of the heart muscle, especially through the atrial node. The reduction of myocardial fibers opens calcium channels to adjust the voltage and causes a slow Ca ++ current to enter, during the effect of the plateau voltage. This Ca ++ line allows absorbing a sufficient amount of calcium ions to stimulate the release of calcium ions from the mesh, thus causing muscle contraction.

On the muscular nervous system: Calcium ions play an important role in stimulating and contraction. The stimulation of muscle contraction of calcium ions when released from the mathematical net. Calcium cans release muscle stimulation by calcium ions attached to troponin, losing troponin inhibition on Actin - Myosin interaction. Muscle dilatation occurs when calcium ions are brought back to the mental mental, restoring the inhibition of troponin.

Calcium chloride irritates the gastrointestinal tract and causes tissue necrosis, so it is never injected into tissues or muscles.

calcium chloride is used by intravenously at a concentration of 100 mg/ml. Should be injected slowly (no more than 1 ml/minute) to prevent increasing Ca ++ concentration in the blood that affect the heart and cause fainting. Hypertension usually occurs after injection due to vasodilation. Calcium chloride is an acid salt so it is not used when treating blood calcium caused by kidney failure.

pharmacokinetics

After use, calcium ions eliminate urine and filtered in the glomerular and have a certain amount of reabsorption. The reabsorption in the renal tubules is huge because 98% of calcium ions are absorbed again - circulating. This reabsorption is adjusted by parathyroid hormones (PTH) and is also affected by the filtering Na+, the presence of non -reabsorbing anion, ureter benefits. The diuretic benefits are active on the upward branch of the Henle straps, increasing calciumuria. On the contrary, only the diuretics are not the cohesion between excretion of Na and Ca ++ so it reduces calcium urine.

Armor hormone regularly regulates blood calcium levels by acting on the renal tubules, calcium urine is only very small by a low calcium diet in normal people.

calcium excreted quite a lot of milk during breastfeeding; There is a calcium excreted through sweat and also excreted through feces.

Before taking Vidipha calcium chloride injection solution treats convulsions, laryngeal spasms caused by lowering blood calcium (100 tubes x 5ml)

How to use

intravenously.

Dosage

anti -calcium blood calcium or supplement electrolytes

Children:

25 mg/kg body weight, slow injection.

Adults:

500 mg - 1 g (1 - 2 tubes). Slow intravenous injection at a speed must not exceed 0.5 - 1 ml for 1 minute, this dose can be used to repeat the distance of 1-3 days depending on the response of the patient and the calcium concentration in the serum.

anti -potassium hyperka

Must adjust the dose through regular monitoring with electrocardiograms.

anti -tank Magnesi blood

intravenous injection, starting 500 mg (1 tube) repeat if the clinical condition is necessary.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Expression:

When the calcium concentration in serum exceeds 2.6 mmol/liter (10.5 mg/100 ml) is considered as a hypercalcemia. Not only an additional calcium or any drug that causes hypercalcemia to solve mild hypercalcemia in patients with no symptoms and normal kidney function.

Management:

When the calcium concentration in serum exceeds 2.9 mmol/liter (12 mg/100 ml), it must immediately use the following measures:

Water compensation by intravenous solution of 0.9%sodium chloride solution. Adrenocorticoid during treatment.

What to do when forgetting a dose?

Side Effects

When using 5 ml calciclorid, you may experience unwanted effects (ADR).

Common

: ADR> 1/100

Circulation: Hypotension (dizziness), peripheral vessels.

digestive: constipation, flatulence, nausea, vomiting.

Skin: Red skin, extravagant, pain or burning in the injection place, nerve pain. Hot and hot.

Uncommon: 1/1000

Neurological: sweating.

circulating: arrhythmia, acute heart dysfunction.

Rare: ADR

Blood: thrombosis.

Note: Notify the doctor the unwanted effects encountered when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Calcicloride 5 ml contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Unsonienced with ceftriaxon in young children because of the risk of precipitation.

Dear heart treatment or electromechanical separation.

ventricular vibration in cardiac resuscitation.

Hypercalcemia, as in people with hyperpigmentation, overdose due to vitamin D.

Kidney stones and severe renal failure.

is using digitalis or epinephrin.

Bone malignant.

Heavy calcium urinary increase.

Established osteoporosis.

Precautions when used

Avoid intravenous injection too fast (less than 1 ml/minute) and avoid exit.

For respiratory failure or acidosis, hypercalcemia may occur when reducing kidney function, regular checking blood calcium.

Avoid metabolic acidosis (only 2-3 days of calcium chloride use, then switch to other calcium salts). 10% calcium chloride injection is only for injection in the heart or slow intravenous injection. Be careful not to penetrate the tissues around the circuit because it can cause necrosis. The solution should be warmed to body temperature. The injection should be done slowly through a small needle into a large vein to minimize venous irritation and avoid unwanted reactions. It is especially important to prevent heart from a high calcium concentration because of the risk of heart fainting. In cardioma care, it is necessary to be injected into ventricular cavity to avoid injecting of myocardial tissue.

Do not give children a calcium chloride injection because they can irritate the gastrointestinal tract. Injections for babies should not cross the scalp.

Do not use calcium chloride for patients with respiratory acidosis or respiratory failure due to acidification of salt.

Cases of deadly reactions to the precipitate of calcium ceftriaxon in the lungs and kidneys in newborn babies lack less than 1 month and full monthly age has been described. At least one of them received Ceftriaxon and calcium at different times and via different veins. In data science available, there is no report confirming the precipitation in the circuit in patients, both newborns, treatment with solutions containing ceftriaxon and calcium and solutions containing calcium or any other calcium -containing products.

Injecting calcium chloride causes intravenous irritation and is not injected into tissue, because it may occur severe necrosis and peeling. Special care should be performed to avoid escape or accidentally injected into the tissues around the circuit. If the circuit is absorbed, IV injection at that position should be stopped for a while. In -spot invasion of affected areas with 1%hydrochloride process, can add hyaluronidase, will often reduce venous spasm and dilute calcium in the tissues at the injection site. Applying heat at the injection site can also be helpful.

The ability to drive and operate machinery

There is no document.

Pregnancy

Inadequate information about using intravenous calcium on pregnant women, calcium can pass through the placenta, consider risk benefits.

Breastfeeding period

Calcium goes through milk, cautious when used for breastfeeding women.

Medicinal interaction

Thiazids, Clopamid, Ciprofloxacin, Chlorthalidon, anti -convulsed drugs inhibit calcium excretion through the kidneys.

calcium increases the toxicity of digoxin for the heart.

Increased blood calcium concentration increases the effect of inhibiting the enzyme Na+- K+- Atpase of the heart glycoside.

Storage

Leave a dry place, the temperature does not exceed 30 ° C, avoiding light.

Expiry date: 60 months from the date of production.

Do not use overdue drugs indicated on the packaging.

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