Vigentin medicine 875mg/125mg Pharbaco treats infections (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

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Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

indications

Vigentin 875mg/125mg drugs are indicated in the following cases:

Treatment in a short time (less than 14 days) cases of bacterial infections caused by beta lactamase producers do not respond to the treatment of single aminopenicillin. Cattarrhalis produces beta lactamase: acute and chronic bronchitis, pneumonia - bronchial. Wounds, cellular inflammation.

Pharmacology

Amoxicillin and potassium clavulanat are a combination of bactericidal effects. This change does not change the mechanism of the effect of amoxicillin (inhibiting the synthesis of peptidoglycan bacterial cell membrane) but also has the effect of anti -bactericidal synergies, expanding the effect of Amoxicillin against many bacteria that produce beta lactamase previously resistant to Amoxicillin alone, due to clavulanic acid has high force and attached to Beta Latamase processing.

Gram -positive bacteria:

Air -demand: Streptococcus Faecalis, Streptococcus Pneumonia, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus Arithracis, Listeria Monocytogenes. Clostridium, peptococcus.

Gram -negative bacteria:

Air -demand: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, PasteRae Multocida. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking medicine.

Potassium clavulanate does not affect amoxicillin pharmacokinetics, but amoxicillin can increase the absorption through the gastrointestinal tract and excretion through the urinary tract for potassium clavulanate compared to when using poisonous potassium clavulanate. With a dose of 250 mg (or 500 mg), there will be 5 micrograms/ml (or 8 - 9 micrograms) amoxicillin and about 3 micrograms/ml of clavulanate acid in serum. After 1 hour oral 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food with a common form of preparation.

After drinking, both amoxicillin and clavulanic acid are distributed into the lungs, pleural fluid and peritoneal fluid, passing through the placenta, a small amount of small drugs found in phlegm, saliva as well as in breast milk.

Before taking Vigentin medicine 875mg/125mg Pharbaco treats infections (2 blisters x 7 tablets)

How to use

Take oral use. Can be taken with water but usually stirred in a cup with water before use.

Dosage

Dosage for adults and children over 40 kg

1 tablet 500 mg (500 mg/125 mg) 12 hours/time.

For severe infections and respiratory infections: 1 tablet 875/125 mg/time 12 hours.

Elderly

No dose adjustment.

Dose for children under 40 kg

Can't use dispersed tablets.

kidney failure

When there is a kidney damage, the dose and/or the number of drugs must be changed to respond to kidney damage.

Dosage for people with renal failure (calculated by amoxicillin content).

Creatinine clearance Dosage hour/time. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Abdominal pain, vomiting and diarrhea, some patients with rash, increased agitation or drowsiness.

Handling

Need to stop the drug immediately, treat symptoms and support when needed. If an overdose occurs early, and there is no contraindication, may cause vomiting or gastric lavage. Overdose of 250 mg/day, does not cause any special symptoms and does not need to clean the stomach. Interstitial nephritis leads to urinary retention. Crystal pisses in some cases leading to renal failure. It is necessary to provide enough water and electrolytes to the body to maintain the urology and reduce the risk of crystal pee.

Kidney damage often recovers after stopping the drug. Hypertension can occur even in people with kidney function damaged by reducing amoxicilline elimination and clavulanic acid out of circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Vigentin 875mg/125mg medicine you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, nausea, vomiting.

Skin: Outdoor, itching.

Uncommon, 1/1000

Blood: Eosin hypernagus.

Liver: jaundice of cholestasis, increased transaminase.

Other: Candida vaginitis, headache, fever, fatigue.

Rare, ADR

Systemic: Anaphylaxis reactions, edema.

Blood: A mitigation of platelets, leukopenia, hemolytic anemia.

digestive: fake colitis.

Skin: Steven - Johnson syndrome, diverse erythematosus, epidermal necrosis due to poisoning.

kidney: interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Medicine 875mg/125mg Contraindications in the following cases:

Sensitive to the Beta Lactam group (penicillin, cephalosporin).

Pay attention to the ability to cross allergies to antibiotics in the beta lactam group.

Children under 40 kg of weight.

Be cautious when using

Attention to the elderly, patients with a history of jaundice/liver dysfunction due to the use of amoxicillin and potassium clavunalat.

Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

There may be severe hypersensitivity reactions in patients with a history of allergies to penicillin or other allergens, so before therapy, it is necessary to investigate a history of allergies to penicillin, cephalosporin and other allergens.

Average or severe renal failure should pay attention to adjusting the dose.

Amoxicillin users are red with lymphadenopathy.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Must periodically check the hematology, liver function, and caution during treatment.

There should be a distinct diagnosis to detect cases of diarrhea caused by C. Difficile and fake colitis. There is a high risk of a rash in patients with monon cells.

Patients with urinary phenylketon and patients need to control phenylalanin to be cautious when taking tablets containing aspartam due to Aspartam transformed in the digestive tract into phenylalanin.

The ability to drive and operate machinery

There is no report in the reference.

Pregnancy

Experimental research of the bromousness of the mouse has proven when using oral preparations and injections are not allergic. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The period of breastfeeding

during breastfeeding may be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Interactive drug

The drug can cause prolonged bleeding time and coagulation. So be careful for patients who are being treated with anticoagulants (Warfarin).

Like antibiotics with a broad -effect spectrum that can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient.

nifedipine increases amoxicillin absorption.

Patients with hyperuricemia when using allopurinol along with amoxicillin will increase the ability of amoxicillin.

There may be antagonists between amoxicillin and other alkaline bacteria.

Amoxicillin reduces methotrexate secretion, increases toxicity on the digestive tract and hematopoietic system.

Probenecid when taken right before or taken simultaneously with amoxicillin reduces amoxicillin elimination.

Storage

In closed packaging, in a dry place, less than 30 ° C.

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