Vigisup Korea Prime vaginal placement treats vaginal and cervical infections (2 blisters x 6 tablets)

Dosage form Box of 2 blisters x 6 tablets
Specifications Neomycin, nystatin, polymyxin b

Ingredient

Composition information	Content
Neomycin	50.2mg
Nystatin	100000iu
Polymyxin b	35000iu

Uses

indications

Vigisup sup Soft Capsule is indicated in the following cases:

Local treatment for vaginal and cervical infections due to candidiasis, vaginal infections due to non -special bacterial strains, vulva inflammation, supportive treatment in vaginal discharge.

Pharmacokinus

Neomycin is an aminoglycoside antibiotic that has the same mechanisms and spectrums similar to the Gentamicin Sulfate. Neomycin sensitive bacteria such as: Staphylococcus aureus, Escherichia Coli, Heamophilus Influenzae, Klebsiella, Enerobacter and Neisseria spp. Neomycin does not work with Pseudomonas Aeruginosa, Serratia Marcescens, Streptococci including Streptococcus Pneumoniae or Streptococcus.

Nystatin has the effect of restraining or killing fungi depending on the concentration and sensitivity of the fungus, not affecting the bacteria that are normal on the body. The most sensitive is the yeast and has a very good effect on Candida Albicans.

Polymyxin B has a bactericidal effect. The antibacterial activity of polymyxin B restricted on Gram -negative bacteria, including Enterobacter, E.coli, Klebsiella, Salmonella, Pasteurella, Borderella, Shigella and Pseudomonas Aeruginosa.

The combination of three effects in which the main antibacterial spectrum of neomycin and polymyxin B, which are antibiotics that have the same impact on most gram -positive and gram -negative bacteria. Streptococci and anaerobic taste resistance to both antibiotics. Nystatin is an annual anti -drug that has a very effective impact on Candida and has an impact of covering and protecting the vaginal mucosa and helps the drug to be well tolerated on the spot.

Dynamic pharmacokinetics

Neomycin is poorly absorbed through the gastrointestinal tract. The absorption of the drug may increase when the mucosa is inflamed or damaged. When absorbed, the drug will quickly eliminate through the kidneys in the form of activity. Half life of the drug is about 2-3 hours.

Nystatin is poorly absorbed through the gastrointestinal tract, not absorbed through the skin or mucosa when used on the spot, excreted mainly through the form of unprover.

Polymyxin B Sulfate is well absorbed through the peritoneal; Do not absorb through the gastrointestinal tract, except in young children can absorb up to 10% of doses; Not significantly absorbed through the mucosa and skin intact or peeling the outer coating as in the case of severe burns.

polymyxin is widely distributed in body tissues, not seen in cerebrospinal fluid (even when the meninges are inflamed) and does not pass the placenta, the polymyxin B Sulfate is not much attached to plasma proteins. Half lifetime of serum on adults with normal kidney function is 4.3 - 6 hours.

About 60% of the absorption drug is eliminated in the form of unchanged urine through glomerular filtration. In adults, during the period between 12 - 24 hours after the initial dose, very few polymyxin B found in the urine, may be due to the drug associated with the phospholipid of the kidney cell membrane. The drug continues to excrete in 24 - 72 hours after the last dose. Young children excreting polymyxin faster than adults; 40 - 60% of the absorption drug is excreted within 8 hours in the urine. Dialysis or peritoneal filtration does not exclude polymyxin b.

Vigisup Soft Soft Capsule vagina is a combination of 3 active ingredients: Neomycin Sulfat, Nystatin and Polymyxin B Sulfate. After placing it into the vagina, the Vigisup Soft Soft Capsule soft capsule will disintegrate and release the active ingredient. The active ingredients in this drug are very poorly absorbed through the mucosa. Therefore, the absorption of the drug, after the vagina, the circulatory system is very limited. The drug is mainly distributed in the vagina and has a local effect.

Before taking Vigisup Korea Prime vaginal placement treats vaginal and cervical infections (2 blisters x 6 tablets)

How to use

vaginal drugs.

Dosage

Dosage for adults: Put 1 tablet in the vagina every day, in the evening at bedtime, continuously for 6 days.

In case of severe or chronic infections: Put 1 capsule in the evening at bedtime continuously for 12 days or 2 capsules a day, use in the morning and evening continuously for 6 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Soft Capsule. In case the patient is overdose and seeing abnormal manifestations should take the patient to the nearest medical facility for timely treatment. Actively monitor for timely measures.

What to do when forgetting a dose? Note: Do not use double the dose to compensate for the forgotten dose.

Side Effects

When using Vigisup Soft Soft Capsule, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Mucus irritation.

Rare, ADR

Rarely allergies. In this case, stop using the drug.

ADR is unknown frequency

may have an allergic eczema due to contact, mostly in case of medication for a long time.

For Neomycin can cause cross -allergies to aminosid antibiotics.

can cause toxicity on the kidneys, ears, short -term treatment will limit this danger.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vigisup sup Soft Capsule is contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Using a condom or a vaginal diaphragm.

Be cautious when using

vaginal drugs, not to be taken. Do not stop using drugs during menstruation (continue to use the drug if menstruation during treatment).

Hypersensitivity to an antibiotic when used on the spot can adversely affect the use of antibiotics or an antibiotic similar to the future.

The drug can cause toxicity across the body (on the kidneys, on hearing, ...), so taking the drug in a short time will reduce these risks.

Although the body has not been recorded at present, the body's adverse effects when taking the medication, it is better to pay attention to this especially for patients with renal failure. The drug contains parabens, which can cause allergies (the reaction may occur slowly).

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

clinically, there is no report on side effects and toxicity. However, like other drugs, this drug should only be used when necessary and the monitoring of a doctor.

The period of breastfeeding

The safety of the drug when used during breastfeeding has not been set up, should only be used in the case of really necessary.

Interactive drug

The drug is ineffective when using condoms or products made from plastic, latex.

Storage

Storage in closed packaging, cool dry places, avoid light, temperatures below 30 ° C.

Other drugs

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