Vinaflam 500 antibiotics for medium respiratory infections (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Cefuroxime

Ingredient

Composition information	Content
Cefuroxime	500mg

Uses

indications

Vinaflam 500 drug is indicated in the following cases:

Mild mild infections to fit the lower respiratory tract, otitis media and recurrent sinusitis, tonsillitis and recurrent sore throat caused by sensitive bacteria.

Inhabited urinary tract infections, skin and soft tissue infections caused by sensitive bacteria.

Treatment of Lyme Diseases in the first period manifested by the erythema symptoms caused by Borrelia Burgdorferi.

Pharmacology

cefuroxim is a semi -broad spectrum antibiotic in the 2nd generation cephalosporin group, antibacterial activity due to synthetic inhibition of bacterial cell walls by attaching essential proteins.

Cefuroxim has antibacterial activity against many common pathogens, including beta -lactamase/cephalosporinase strains of both gram -positive and gram -negative bacteria. Cefuroxim is active in gram (-) bacteria larger than generation cephalosporin but narrower than generation cephalosporins. Cefuroxim is active on Gram (-) bacteria such as E.coli, Enerobacter, Klebsiella, Neisseria.

Pharmacokinetics

absorption

After drinking, Cefuroxim acetyl is absorbed through the gastrointestinal tract and is quickly hydrolyzed in the intestinal and blood mucosa to release Cefuroxim into the circulatory system. Birth in adults is 37% (used when hungry), 52% (when there is food). The peak concentration depends on the dose of 250 - 500mg respectively 4.1 and 7 mcg/ml after 2 - 3 hours, AUC 27.4 mcg - H/ml.

Distribution

The distribution volume is 9.3 - 15.81/1.75m2, connected 33 - 50% to plasma protein. Cefuroxim is widely distributed throughout the body, including pleural fluid, sputum, bone, fluid and aquatic fluid. Cefuroxim passes through the bloody barrier when the meninges are inflamed. Medicine through placenta and excretion through breast milk.

Metabolism and elimination

Cefuroxim is not metabolized and eliminated in the form of unchanged, about 50% through glomerular filtration and about 50% through excretion in the renal tubules.

Before taking Vinaflam 500 antibiotics for medium respiratory infections (2 blisters x 5 tablets)

How to use

Vinaflam 500 is an oral medication.

Dosage

Adults and children aged 13 and older

Adults: Take 2 capsules/time, 2 times a day, can be up to 2 capsules/day.

The only dose of 2 tablets in cervical gonorrhea or uncomplicated urethra, or uncomplicated rectal gonorrhea in women.

Take 1 capsule/time, 2 times a day, for 20 days in the new lymphoma.

For patients with renal impairment or a kidney or elderly patient when drinking without an overdose of regularly 1 g/day.

Treatment time in regular infections is 7-10 days.

Cefuroxim acetyl -containing tablets are not allowed to be crushed so it is not recommended to use the tablet form for children. For the dose of 250 mg/time: 01 tablet should be used, it is not advisable to use 2 tablets of 500 mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

Causes nausea, vomiting and diarrhea. In people with kidney failure can cause seizures.

Handling

It is necessary to pay attention to the overdose of many drugs, abnormal drug interaction and pharmacokinetics in patients. Protect the respiratory tract of the patient, support ventilation and infusion. If developing convulsions, stop using the drug immediately; Anti -seizures may be used if clinically indicated. Hemorrhage can be from blood from blood, but most of the treatment is supporting and resolving symptoms.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Vinaflam 500 medicine, you may experience unwanted effects (ADR).

Common

diarrhea, lumpy skin.

Less

Anaphylaxis reactions, candidiasis infections, Eosin hyperpses, leukopenia, neutropenia, positive Coombs test, nausea, vomiting, urticaria, itching, creatinine in serum.

Rare

Fever, hemolytic anemia, fake colitis, polymorphic erythema, Stevens - Johnson syndrome, poisoned epidermal necrosis, cholest jaundice, AST, alt, renal poisoning with temporary hypertonic hypertension, blood creatinine, interstitial nephritis, convulsions, headaches, agitation, joint pain.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vinaflam 500 medicine is contraindicated in the following case:

Patients with a history of allergies to cephalosporin antibiotics.

Be cautious when using

Caution for patients with a history of allergies to cephalosporin, penicillin or other drugs.

People with gastrointestinal diseases.

In serious ill people who are taking the maximum dose, kidney test when treated with cefuroxim.

Should be cautious when giving patients simultaneously with strong diuretics, because it can be adverse effects on kidney function.

The ability to drive and operate machinery

does not affect.

Pregnancy

cephalosporin is often considered safe to use during pregnancy. However, this medication should only be used on pregnant people if needed.

Breastfeeding period

cefuroxim excreted in breast milk at low concentrations. It seems that this concentration does not have an impact on breastfed babies, but should be concerned when children see diarrhea, wasting and rash.

Drug interaction

ranitidin with sodium bicarbonate reduces the bioavailability of cefuroxim acetyl.

Should take the drug at least 2 hours after antacids, antihistamine H2 because these drugs can increase the gastric pH.

Probenecid increases the effects of cefuroxim.

aminoglycosides increase the toxicity of the kidneys.

Storage

Leave a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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