Vincomid injection 10mg/2ml Vinphaco prevent vomiting and postoperative nausea, radiation therapy (2 blisters x 5 tubes x 2ml)

Dosage form Box of 2 blisters x 5 tubes x 2ml
Specifications Metoclopramid hydrochloride

Ingredient

Thành phần cho 2ml

Composition information	Content
Metoclopramid hydrochloride	10mg

Uses

Indications

Vincomid Vinphaco 2 blisters x 5 tubes x 2 ml are indicated in the following cases:

Adults:

Preventive prophylaxis and postoperative nausea.

is a second-line choice (Second-line) to prevent vomiting and nausea that appear late due to chemotherapy. Dopamine, making receptors in the digestive tract sensitive to acetylcholin.

The anti-vomiting properties of Metoclopramid are due to direct dopamine resistance to receptor and vomiting centers and the antagonistic effect on the serotonin-5HT3 receptor.

Dynamic pharmacokinetics

After intramuscular injection, the drug starts to work after 10 to 15 minutes, when intravenously after 1-3 minutes. Metabolic through the liver for the first time reduces the bioavailability of the drug to about 75%.

Easy drugs through blood barriers - brain and placenta.

up to 30% of excreted drugs in the form of non -metabolized urine, the rest are excreted through urine and bile in the form of sulfate or glucuronic acid.

The half -life of the drug is about 4-6 hours, but it can also be up to 24 hours in patients with impaired kidney or cirrhosis.

Before taking Vincomid injection 10mg/2ml Vinphaco prevent vomiting and postoperative nausea, radiation therapy (2 blisters x 5 tubes x 2ml)

How to use

Usern's intramuscular or intravenous drug for at least 3 minutes.

Dosage

Adults

Preventive vomiting and postoperative nausea: recommendations of 10 mg.

Preventive vomiting and nausea due to radiation therapy: Recommendations of 10 mg x up to 3 times/day.

Treatment of symptoms of vomiting and nausea, including vomiting and nausea due to acute migraine: Recommended the dose of 10 mg x up to 3 times/day.

Maximum doses recommend: 30 mg/day or 0.5 mg/kg/day.

Treatment time: Take the drug in the shortest time, then can switch to oral medication or rectal lines.

Children from 1 - 18 years old

With all the indications: recommend the dose of 0.1-0.15 mg/kg x up to 3 times/day, intravenously.

Maximum dose: 0.5 mg/kg/day.

Treatment time:

Preventive vomiting and nausea appear late due to chemotherapy: Maximum within 5 days.

Treatment of vomiting and postoperative nausea: maximum within 48 hours.

Elderly

Should consider reducing the one -time dose to take the drug based on the liver and physical function.

Patients with renal failure

end -stage renal failure (Creatinine clearance

Severe or medium renal failure (Creatinine clearance 15-60 ml/min): The dose should be reduced to 50%.

Patients with liver failure

Severe liver failure: The dose should be reduced to 50%.

Children under 1 year of age

Contraindicated Metoclopramid for children under 1 year of age.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Periodic disorders, drowsiness, reduced cognitive ability, confusion, hallucinations, cardiac arrest, apnea.

Processing:

In the event of a pupils disorders, maybe due to an overdose or not, Metoclopramide should be stopped and used for symptomatic medications including benzodiazepine in young children and/or cholinergic drugs for Parkinson's treatment in adults. It is necessary to treat symptoms and continuously the cardiovascular and respiratory functions depending on the patient's clinical condition.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Vincomid Vinphaco 2 blisters x 5 tubes x 2 ml, you may experience unwanted effects (ADR).

Very common, common ADR> 1/100

Digestive: diarrhea.

Neurological - Mental: Drowsy, Drinking, Parkinson's Park Disorders, Parkinson's Syndrome and Sitting restless, depressed.

cardiovascular: hypotension, especially when using intravenous sugar.

Uncommon, rare, ADR

Cardiovascular: shock, fainting after injection, acute hypertension in patients with adrenal marrow tumors, slow heart rate, especially with intravenous products.

Hormonal: loss of menstruation, increased blood prolactin, lots of milk.

immunity: Hypersensitivity.

Neurological - Mental: Muscle disorders, movement disorders, reduced cognitive ability, convulsions, especially in epilepsy patients, hallucinations, confusion.

Unknown frequency, ADR

Hematology: Methemoglobin blood, sulfhemoglobin.

Cardiovascular: cardiac arrest, atrial block, sinus stops, extending the QT distance on the center of the center, the top torsion.

Endocrine: Big breasts in men.

immune: Anaphylactic reaction (including anaphylaxis).

Neurological: Late movement disorders may not recover, during or after prolonged treatment, especially in elderly patients, malignant neuron syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Vincomid Vinphaco 2 blisters x 5 tubes x 2 ml contraindicated in the following cases:

Hypersensitivity to metoclopramid or any ingredients of the drug.

Gastrointestinal bleeding, mechanical obstruction or gastric perforation due to drugs that increase bowel movement and can make the patient's condition worse.

adrenal oral medulla or adrenal marrow suspects due to the risk of dramatic hypertension.

There is a history of movement disorders caused by metoclopramid or sedative dysfunction.

Epilepsy (with increasing density and intensity of seizures).

Parkinson.

Used in combination with levodopa or dopamine owners.

There is a history of hematoma methemoglobin due to metoclopramid or NADH cytochrome B5 Reductase.

Children under 1 year of age, due to the increased risk of foreign towering disorders on this object.

Be cautious when using

may occur symptoms of pupils disorders, common in children and young people and/or when using high doses. These reactions usually occur in the first phase of the drug, some cases occur after a single dose. Should stop the drug as soon as there is a manifestation of the pagoda.

In most cases, these symptoms are completely lost after stopping the drug. However, some cases need to use symptomatic medication (benzodiazepin in children and/or anti -antacids of Parkinson's treatment on adults).

The distance of the dose is at least 6 hours, including vomiting or do not use one dose of the drug to avoid the risk of overdose.

Prolonged treatment with metoclopramid can cause late movement disorders, many cases of non -recovery, especially in the elderly. Therefore, do not extend the treatment time for more than 3 months. It is necessary to stop taking the drug as soon as there are manifestations of late -clinical movement disorders.

Malignant neuroleptic syndrome has been reported to Metoclopramid for use as well as in collaboration with other sedatives. Patients need to stop the drug and take appropriate treatments as soon as the manifestations of malignant neurolithic syndrome occur.

Be careful to monitor patients with neuropathy and patients being treated with medications with central effects. Metoclopramid may worsen Parkinson's symptoms.

Some cases of blood methemoglobin may be related to NADH Cytochrome B5 Reductase deficiency. When the patient shows methemoglobin blood, it is necessary to stop the drug immediately and have appropriate treatments such as methylene green. In these cases, never reusing Metoclopramid for patients.

Be careful to monitor patients using Metoclopramid, especially in the case of intravenous medication for the elderly, patients with heart disease disorders (including extension of QT), patients with electrolyte disorders, bradycardia, and patients with other drugs that are at risk of extending QT.

In case of intravenous medication: slow intravenous injection for at least 3 minutes to reduce the risk of adverse reactions such as hypotension and restless sitting.

The ability to drive and operate machinery

The drug can cause drowsiness, dizziness, movement disorders, muscular disorders and can affect the vision and ability to drive as well as operate the drug user of the drug user.

Pregnancy

Due to the pharmacological characteristics of Metoclopramid similar to other sedatives, taking the drug at the end of pregnancy may cause a risk of extracurricular syndrome on children. Therefore, avoid using metoclopramid at the end of pregnancy; In case of drug use, closely monitor the above manifestations.

The period of breastfeeding

metoclopramid is excreted in small amounts of breast milk, so breastfed babies are at risk of adverse drug reactions. Therefore, it is not recommended to use metoclopramid during breastfeeding. On breastfeeding women use metoclopramid, it is necessary to consider stopping the drug.

Drug interaction

Contraindications to coordinate Metoclopramid with levodopa or dopamine owners due to mutual antagonism.

Alcohol can increase the central neurological inhibition effect of Metoclopramid.

Because metoclopramid increases the peristalsis of the gastrointestinal tract, it can change the absorption of some drugs such as anti -cholinergic drugs, central painkillers (Morphin derivatives, anti -anxiety drugs, sedative drugs, H1 anti -antidepressants, Barbiturat, Clonidine and related drugs), Serotonergic, Digoxin, cyclospor, cyclosin Mivacurium and Suxamethonium.

Strong CYP2D6 inhibitors: such as fluoxetin and paroxetin, increasing the level of exposure to Metoclopramid in patients.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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