Vinocyclin 50 medisun treat acne, respiratory infections (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Minocyclin

Ingredient

Composition information	Content
Minocyclin	50mg

Uses

indications

Minocyclin 50 drugs are an antibiotic, which has the same spectrum as Tetracyclin antibiotics but more powerful on Staphylococcus aureus and Nocardia spp. Minocyclin is indicated for treatment in cases such as acne, respiratory infections, gonorrhea, staphylococcal infections and preventive treatment for meningococcal infections.

Pharmacokic

ATC code: J01AA08. Semi -synthetic antibiotics tetracyclin.

Minocyclin is a broad -spectrum antibiotic, which works on many gram -negative and gram -positive bacteria, both aerobic and anaerobic, twisted bacteria and intracellular bacteria: Streptococcus pneumonia, Streptococcus pyogenes, Bacillus anthracis, Listeria monocytogenes, Bartonella Bacillell, Campylon Fetus, Francisella Tularensis, Vibrio Cholera, Yersinia Pestis, Escherichia Coli, Haemophilus Influenza .... Minocyclin is similar to other tetracyclin, but more sensitive to Staphylococcus aureus and Nocardia spp.

The mechanism of action of minocyclin has a bacterial effect due to inhibiting the synthesis of bacterial proteins by attaching to the 30S part of ribosom, which inhibits the attached aminoucyl-Arny to the reception position.

Drug resistance: The drug resistance ratio may vary in geographical and time area. Currently, some bacteria resist tetracycline antibiotics are very common, and are often cross -resistant to tetracyclin antibiotics. Minocyclin is commonly used in in -shitro to fight propionibacterium acnes - a species related to acne.

Dynamic pharmacokinetics

minocyclin well absorbed through the gastrointestinal tract, almost completely after drinking.

The absorption of minocyclin is not significantly affected by food and milk. The dose of 200 mg per day or 100 mg every 12 hours for plasma concentrations is 1 - 4 mg/ml.

The semi -exhaust time of minocyclin is 12-16 hours in patients with normal renal function, but lasts in patients with impaired renal function.

Minocyclin is widely distributed throughout the entire body and tissues. Minocyclin passes through the placenta fence and is excreted in breast milk.

Before taking Vinocyclin 50 medisun treat acne, respiratory infections (3 blisters x 10 tablets)

How to use

Vinocyclin 50 drugs are taken orally.

Dosage

adults:

Using antibiotics regularly: 100 mg/time x 2 times/day.

Acne: 50 mg/time x 2 times/day or 100 mg/time x 1 time/day.

Gonorrhea:

Adult men: 200 mg of initial dose, followed by 100 mg every 12 hours, at least 4 days, implantation of urine check for 2-3 days after stopping the drug. Maintain for 5 days, then often accompanied by a rifampicin treatment.

Children:

Vinocyclin 50 is not recommended for children under 12 years old. For children over 12 years old, the recommended dose is 50 mg every 12 hours or 100 mg/time x 1 time/day.

Old people:

Vinocyclin 50 can be used in the usual dosage for older patients but need to be cautious in patients with renal failure.

acne treatment route with minocyclin should be extended continuously for at least 6 weeks. If after 6 months of treatment, no progress should stop using the drug and consider other treatment. If using minocyclin for 6 months, patients should be monitored at least 3 months after treatment of signs and symptoms of hepatitis or erythema lupus.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: There is no specific overdose treatment. When an overdose occurs, gastrointestinal bowel is combined with symptom support.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Common, 1/100 ≤ ADR

Neurological: dizziness. These disorders can recover after stopping the drug within 3 - 48 hours and are rarely reported if used in low doses.

Rare, 1/10000 ≤ ADR

Neurology: headache, bored, intracranial hypertension, dizziness. These disorders can recover after stopping the drug within 3 - 48 hours and are rarely reported if used in low doses.

Some rare cases such as esophagitis and esophagitis have been reported in patients using capsules and tablets. Mostly due to medication before going to bed.

Blood and lymphatic system: Reducing eosinophilia, leukopenia, neutropenia, thrombocytopenia.

Nervous system: decreased sensation, paresthesia.

Skin and subcutaneous tissue: Diverse hair loss, pink rash, pink rash, tanning, sensitive to light, rash, urticaria.

Kidney: increased blood urea, acute kidney failure, interstitial nephritis.

Digestive: diarrhea, nausea, dental inflammation, color variables in adults, vomiting.

ears: poor hearing, tinnitus.

Liver: increased liver enzymes, hepatitis, autoimmune liver toxicity.

immune system: bleeding/anaphylactic reaction (shock).

Metabolism and nutrition: Anorexia.

Heart: myocarditis, pericarditis.

Respiratory: cough, shortness of breath.

musculoskeletal joints: arthritis, lupus syndrome, muscle pain.

Very rare, ADR

The immune system: Oral and genital infections, vaginitis.

blood and lymphatic system: hemolytic anemia, ischemia.

Liver: Hepatitis, liver failure, hyperlirubin blood, jaundice.

Endocrine: Abnormal thyroid function, brown -black disorders of the thyroid gland.

Gastrointestinal: indigestion, difficulty swallowing, reducing enamel, bowel inflammation, esophagitis, ulcerative ulcer, ulcers, pancreatitis, fake colitis.

Neurology: inflation.

musculoskeletal joints: arthritis, bone discoloration, manifestation of serious erythema lupus syndrome, stiffness, swelling.

Reproduction: Foreskin.

Respiratory: Bronchospasm, serious asthma, eosinophilia in the lungs.

Skin and subcutaneous tissue: edema, Stevens Johnson syndrome and peeling dermatitis, nail hyperpigmentation, poisoning epithelium necrosis (ten).

In addition, the reports on:

Blood and lymphatic system: granulocytic loss.

The immune system: sensitivity, lung infiltration, allergic bleeding.

Neurology: convulsions, sedation.

Respiratory: Inflammation.

Digestive: There are reports on changes in the oral cavity, including tongue, lips and gums.

Liver: Autoimmune hepatitis.

Notify the physician with unwanted effects when using the drug.

Unwanted treatment:

Some cases of the following symptoms have reported death or serious side effects. If you recognize any syndrome in the following syndrome, it is necessary to ask the patient to stop using the drug:

Hypersensitivity syndrome: Including skin reaction (rash or skin peeling), hyperphaules and one or more symptoms: hepatitis, pneumonia, nephritis, myocarditis, pericarditis. There may be fever and lymph nodes.

Lupus -like syndrome: Including positive for antibodies, joint pain, arthritis, joint spasms or swelling, and 1 or more symptoms: fever, muscle pain, hepatitis, rash, vasculitis.

Serum disease syndrome: Including fever, urticaria or rash, joint pain, arthritis, stiffness or swelling of joints. Can increase leukemia.

The hyperpigmentation may be in different body areas: skin, nails, teeth, oral mucosa, bones, thyroid, eyes, breast milk, sweat. Blue/black/gray or mud shift can be localized or diffused. The change in pigmentation may be lost when stopping the drug, whether it may take several months or in some cases still after stopping the use of the drug. The mud -brown skin pigments often exist, especially in the areas of the body exposed to the sun.

Consider the benefits and risks when patients have unwanted effects.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindicated minocyclin in the following cases:

hypersensitively to minocyclin, tetracyclin or any ingredients of the drug.

Be cautious when used

Vinocyclin 50 is used cautiously in patients with liver dysfunction, alcohol use or being used to poison with other liver.

Cross -resistance to tetracyclin can develop microorganisms and increase cross -sensitivity in patients. Minocyclin should be discontinued if there are signs or symptoms of excessive increase in bacterial resistance such as tongue inflammation, stomatitis, vaginitis, itching or staphitis.

Use minocyclin in patients who are taking birth control pills if diarrhea or sudden bleeding, the possibility of contraception is not effective.

Rarely have liver toxicity or acute symptoms of the system that has been reported.

If the patient has signs of systemic lupus or liver poisoning, the drug should be discontinued.

Needs on the use of minocyclin with patients with myasthenia gravis. Like tetracyclin, minocyclin can inhibit nerves.

Patients with genetic problems in galactose tolerance, malventia - galactose are not tolerant.

The effect of the drug on the ability to drive and operate machinery

Due to some side effects when using the drug can affect the ability to drive and operate machinery, thus need to be cautious when taking the drug for these objects.

Use drugs for women during pregnancy and lactation

Do not use minocyclin during pregnancy. Animal research shows that tetracyclin through the placenta and found in fetal tissue and can be toxic to the fetus associated with bone development.

Do not use minocyclin for breastfeeding women.

drug interaction

Because tetracyclin reduces the activity of prothrombin in plasma, patients are being treated with anticoagulant drugs must be reduced anticoagulant dose when used simultaneously with minocyclin.

Do not use minocyclin simultaneously with other penicillin drugs.

antacids and preparations containing aluminum, iron, calcium, magnesium, bismuth or zinc salts reduce the absorption of minocyclin, so do not use Vinocyclin 50 simultaneously with these drugs.

Unused minocyclin with oral contraceptives due to reducing the effectiveness of birth control pills.

Minocyclin used simultaneously with diuretics can increase the toxicity of the kidneys.

Storage

Store at a temperature not exceeding 30 ° C in the original packaging, avoid moisture and avoid light.

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