Vinphaco vitamin B12 injections treat malignant anemia (100 tubes x 1ml)

Dosage form Cyanocobalamin
Specifications Vinh Phuc DP Joint Stock Company

Ingredient

Composition information	Content
Cyanocobalamin	1000

Uses

indications

Vitamin B12 drugs are indicated in the following cases:

Treatment of malignant anemia and other large red blood cells.

Pharmacology

Vitamin B12 is the common name for a group of compounds containing cobalt (cobalamin), in which cyanocobalamin and hydroxocobalamin are two main drugs used in clinical.

In the human body, Cyanocobalamin forms coenzyme active as methylcobalamin (Mecobalamin) and 5 - Deoxyadenosylcobalamin (COBAMAMID) is essential for copying and growth cells, hematopoietic, synthesizing nucleoprotein and myelin. Methylcobalamin is needed to create methionine and conduct as s-adenosylmethionin from homocystein.

methylcobalamin is also closely related to folic acid in some important metabolic paths. When vitamin B12 concentrations are not sufficient, it will cause a decline in the function of some other types of folic acid in the cell. Hematology abnormalities in people with vitamin B12 deficiency are due to this process.

5 - Deoxyadenosylcobalamin is essential for isomer, L - methylmalonyl coa into success. Vitamin B12 is essential for all tissues with strong cell growth such as hematoma, small intestine, and uterus. Vitamin B12 deficiency can cause non -recovery damage in the nervous system, myelin is destroyed, has seen nerve cells in the spine and cerebral cortex die, causing a number of neurological symptoms such as abnormalities in the hands, feet, loss of tendon reflexes, confusion, memory loss, hallucinations, mental disorders.

These nerve damage can occur without changes in hematopoietic systems. Therefore, Vitamin B12 deficiency also needs to be set for the elderly to dit intellectually or have mental signs even without anemia. The mechanism that causes nerve damage due to the lack of B12 is not well known, maybe due to the deficiency of the synthetase methionine and due to methionine, it does not switch to S - adenosylmethionin.

Dynamic pharmacokinetics

After intramuscular injection, the peak concentration in plasma is achieved after 1 hour. After entering the blood, Cyanocobalamin attaches to Transcobalamin II is a plasma globin to be transported to the tissues. The liver is home to 90% of cyanocobalamin reserve, some kidney reserves. Cyanocobalamin is metabolized in the liver. Selling time is about 6 days. Cyanocobalamin is eliminated through bile and has a liver - intestinal cycle. Cyanocobalamin exceeds the daily demand that is excreted in urine mostly in the form of non -metabolic.

Before taking Vinphaco vitamin B12 injections treat malignant anemia (100 tubes x 1ml)

How to use

Used by intramuscularly.

Before using, you need to shake the tube evenly, then break the tube, can lined with a cloth.

Only use the drug if it is transparent and colorless.

Dosage

vitamin B12 (cyanocobalamin) is usually supplemented for people deficit in the form of oral, but in some cases, patients cannot be used to use the injection.

Dosage is prescribed in cases of malignant anemia and other large red blood cells as follows:

Start: Intramuscularly 250 - 1000 mcg/time, 1 time a day for 1-2 weeks, then 250 mcg each week until the number of blood cells return to normal.

Maintenance dose: 1000 mcg intramuscularly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? Do not increase the dose when forgetting to use the drug.

Side Effects

When using vitamin B12, you may experience unwanted effects (ADR).

Immune allergic reactions are rare, but sometimes very heavy can be deadly after injecting COBALAMIN.

Rare, ADR

Body: Anaphylaxis reaction, fever, headache, dizziness, bronchospasm, mouth angio - servant.

Dermatology: Reaction of acne, urticaria, itching, red rash.

Pain, sclerosis at the injection site, hematoma in the limb after injection.

digestive: nausea.

Secondary arrhythmia due to hypokalemia at the beginning of treatment.

Instructions on how to handle ADR

Unwanted effects are often light, except for anaphylactic reaction. Emergency treatment must be treated with anaphylactic reaction with adrenalin injection, artificial respiration, oxygen breathing.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vitamin B12 is contraindicated in the following cases:

People who are sensitive to any component of the product.

People with a history of allergies to cobalamin and related substances.

malignant tumor (the risk of causing tumors developed by vitamin B12 increases high growth tissue).

Treatment of Leber’s or vision impairment due to smoking.

Precautions when using

there is no indicator without a definite diagnosis. Regularly monitor the patient's blood.

Most huge red blood cell anemia is due to vitamin B12 deficiency or folic acid. It is necessary to identify the cause before treatment, not to use folic acid to treat huge red blood cell anemia has not determined the cause, unless combined with vitamin B12, otherwise it will promote neurological damage due to vitamin B12 deficiency.

The ability to drive and operate machinery

The drug can cause headaches, dizziness. Do not drive, operate machinery or work on high when encountered unwanted effects of the drug.

Pregnancy

There is no full research on humans. No problem occurs when using vitamin B12 with daily recommended dose. When used with treatment dose, it is necessary to consider the benefits of the mother and the potential danger to the fetus.

Breastfeeding period

Vitamin B12 is distributed into breast milk. No problem occurs when using vitamin B12 with daily recommended dose. When you have to use vitamin B12 for mothers in the case of pathology, lactation is not a contraindication.

Medicinal interaction

Serum concentration may be reduced when used simultaneously with oral contraceptives. Chloramphenicol used on the gastrointestinal tract may reduce the effect of vitamin B12 in anemia.

Cavalry

can mix vitamin B12 in a solution with vitamin B1, vitamin B6 or with iron fumarate, ascorbic acid, folic acid, copper sulfate, or with iron fructose and folic acid in some types of injection.

Cyanocobalamin is similar to the sodium warfarin solution.

Storage

Store in a dry place, temperature below 30 ° C, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.