Vinphason 100mg injection Vinphaco treatment of lupus erythematosus system, severe diverse roses (1 bottle + 1 tube)

Dosage form Box
Specifications Hydrocortison Sodium Succinat

Ingredient

Composition information	Content
Hydrocortison Sodium Succinat	100mg

Uses

indications

Vinphason freezer powder is an anti -inflammatory drug that is indicated for any condition that requires fast and strong corticosteroid effects such as:

Collagen diseases: Systemic lupus. Thick.

Hydrocortison is a corticoid secreted from the adrenal gland, belonging to the glucocorticoid group that has anti -inflammatory, allergic, anti -itching and immunosuppressive effects.

Hydrocortison Succinat soluble in water, quickly hydrolyzed into activated hydrocortison thanks to the blood ester.

Dynamic pharmacokinetics

absorbing: When using intravenous ester -soluble intravenously, the drug quickly reaches high concentrations in body fluids.

Distribution: After absorption, about 90% of the drug is attached to plasma proteins, mainly with corticosteroids - binding globulin (CBG, a type of α2 - globulin synthesized in the liver) and albumin. Only the drug in the form of free to penetrate the target cell and cause pharmacological effects.

Metabolism and excretion: Hydrocortison's waste time is about 100 minutes.

Hydrocortison is metabolized in the liver and most of the tissues in the body into hydrogenation and tetrahydrocortison and tetrahydrocortisol. These substances are excreted in the urine, mainly in the form of glucuronid and small amounts in the form of unchanged. Hydrocortison also passes the placenta.

Before taking Vinphason 100mg injection Vinphaco treatment of lupus erythematosus system, severe diverse roses (1 bottle + 1 tube)

How to use

Vinphason freezy powder injected with intramuscular, intravenous injection, intravenous injection.

The priority of the first priority is used as intravenous injection. After the initial emergency phase, it is advisable to consider using injections longer or oral medications.

Prepare the injection solution: Use a sterile syringe to absorb the amount of solvent in the tube into the vial of Vinphason freezers, shake well to completely dissolve the drug.

For intravenous transmission, dilute the solution after solvent dissolved into 100 - 1000ml of 5% Dextrose solution or 0.9% sodium chloride or 5% dextrose solution in isothermic in case the patient is not limited to sodium.

There is no special requirement on drug treatment after use.

Dosage

Dosage recommended from 100mg - 500mg depends on the severity of the emergency condition, intravenous injection between 1 to 10 minutes. The dose can be repeated for about 2 hours, 4 hours or 6 hours depending on the response of the patient and the clinical condition.

High doses of corticosteroid therapy should only be used until the patient's condition is stable, usually not more than 48 to 72 hours. If you continue treating with hydrocortison after 48 to 72 hours, sodium hypertonic. Therefore, methylprednisolon can be used to replace hydrocortison if not occurs or have little sodium holding. Although the effects do not want to be related to the use of short -term corticosteroids, high doses are not common, it is still possible to occur peptic ulcer. Hence can be provided with antacids.

Patients with serious stress after treatment with corticosteroids should be closely monitored with signs and symptoms of adrenal insufficiency.

Corticosteroid therapy is a supportive method, not replacing for conventional therapy.

Patients with liver failure: The effect of the drug may increase, so it is necessary to consider reducing the dose.

Elderly patients:

Hydrocortison is mainly used in acute conditions in a short time.

There is no information that changes the dose in elderly patients. However, the treatment plan for elderly patients, paying attention to more serious consequences of unwanted effects of corticosteroids in old age and need to have close clinical monitoring.

Pediatric:

may reduce the dose for babies and young children. However, the dosage is considered to adjust depending on the severity of the condition and the patient's reaction than the age or body weight. The dose is not less than 25mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

In cases of expressions without typical antagonistic drugs, only supportive treatment and symptomatic treatment. Actively monitor for timely measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

related to hydrocortisone:

In long -term glucocorticoid treatment, the most common ADR is the state of fake Cushing and osteoporosis at different degrees of severity. In contrast, ADR is very rare with short -doses of high doses.

Common, ADR> 1/100

Cardiovascular: edema, hypertension secondary response to the adrenal and pituitary shell, especially during stress, such as when injury, surgery or disease, weight gain.

Gastrointestinal disorders: peptic ulcer, bleeding sores, small intestine ulcer.

Skin reactions: contact dermatitis, skin atrophy, scar healing.

Neurological: headache, dizziness, depression.

can minimize fake cushing syndrome and osteoporosis by carefully selecting steroid drugs, the program uses drugs a day or interrupted; Auxiliary therapy can be effective in the treatment of osteoporosis caused by steroids (calcium, vitamin D ...).

Must be often concerned about bacterial infections caused by "opportunistic" bacteria. If necessary, antibiotics must be used.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vinphason dried freeze -drying powder in contraindications in the following cases:

Hypersensitivity to any component of the drug.

Caution when using drugs

Use cautious for people with gastrointestinal ulcer, new intestinal connection, hypertension, heart failure, myocardial infarction, people with thyroid disease, liver failure, kidney failure, diabetes, tuberculosis, catastrophic, muscle weakness, people at risk of osteoporosis, epilepsy.

When using high doses, prolonged or used for young children, they must pay attention to the risk of inhibition of hypothalamus - pituitary - adrenal glands.

Never use glucocorticoids in the progressive infection, unless previously used anti -bacterial drugs. However, there is still a risk of increasing infections due to immunosuppressive when using glucocorticoids.

Used in the elderly: Unwanted effects of the whole body corticosteroids may be more serious on this object, especially osteoporosis, hypertension, hypokalemia, diabetes, sensitive to infections. Clinical monitoring is necessary to avoid life -threatening reactions. Systemic corticosteroids should not be used in cases of traumatic brain or stroke.

Use drugs for women during pregnancy and lactation

hydrocortison through the placenta. Test on animals, glucocorticoids have harmful effects on the fetus. However, these results do not correspond to humans. However, taking prolonged, high doses will cause the risk of adrenal inhibition of the fetus. Used before labor, glucocorticoids have a protective effect against respiratory failure syndrome is very dangerous for premature babies. Asthma treatment for pregnant women should combine glucocorticoids, because asthma itself is a big risk to the fetus.

The effect of the drug on the ability to drive, operate machinery

The drug can cause unwanted effects such as headache, dizziness, depression (unwanted effects related to Benzylic alcohol components) or excessive excitement, confusion, depression when stopping the drug (related to hydrocortison). Therefore, do not drive or operate machinery when encountered unwanted effects of the drug.

Drug interaction

There has been a seizure report that occurs when used simultaneously corticosteroids with cclosporin. The simultaneous use of these drugs leads to the inhibition of metabolic processes, and the seizures may occur and other side effects related to each individual drug.

Liver enzyme induction drugs such as Rifampicin, Rifabutin, Carbamazepin, Phenobarbiton, Phenytoin, Primidon and Aminoglutethimid increases the metabolism of corticosteroids and can reduce the treatment effects of the drug.

CYP3A4 enzyme inhibitors such as ametidin, erythromycin, ketoconazole, otraconazole, diltiazem and mibefradil can reduce the metabolism rate of corticosteroids and thus increase serum drug levels.

Steroids may reduce the effects of cholinesterase anti -cholininthases in myasthenia gravis. Steroids may increase the desired effect of diabetes treatment (including insulin), anti -hypertension and diuretics against corticosteroids, and hypotension effects of acetazolamid, diuretic, thiazid diuretics and carbenoxolon when used simultaneously.

corticosteroids may increase the effectiveness of anticoagulant drugs at the same time, so it is necessary to closely monitor the INR or prothrombin time to avoid spontaneous bleeding.

When using simultaneously corticosteroids with salisylate may increase the salicylate clearance in the kidney, and when stopping using steroids can lead to Salicylate poisoning. Salicylat and NSAIDs should be used cautiously when combined with corticosteroids in reduced blood prothrombin.

Steroid has been reported as interacting with neurotransmitters such as pancuronium that reverses a part of the neuropathy.

Cavalry: Do not mix the drug with other drugs, except for diluted solutions.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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