Vinsalamin 500 vinphaco treatments for bleeding ulcerative ulcer, Crohn's disease (3 blisters x 10 tablets)

Unlike salicylate, mesalazin is not converted into salicylic acid for pharmacological effects. Mesalazin inhibits cyclooxygenase, reducing the formation of prostaglandin in the colon. As a result, the drug has the effect of inhibiting local inhibitors against the production of metabolites of arachidonic acid, which increases in people with chronic bowelitis. Mesalazin preparations may have a good effect on people who are sensitive to sulfasalazin.

pharmacokinetics

about 25 ± 10% mesalazin released absorbed when oral. The distribution of drugs in tissues and fluid fluid has not been fully described. Mesalazin's plasma sale time is about 40 minutes and 40-50% linked to plasma proteins.

The distribution volume is about 18 liters.

Mesalazin's metabolism has not been clearly proven. The absorption is almost completely acetylation in the intestinal wall and liver into N-acetyl-5-aminosalicylic acid; Mesalazin and N-acetyl-5-aminosalicylic acid can also be combined with glucoronic acid. Time to reach the peak concentration in plasma from 4 - 12 hours. Acetylation metabolites have half -life in plasma for about 70 minutes and about 80% linked to plasma proteins. After drinking, Mesalazin passed the placenta fence but only in an insignificant amount; The amount of drugs distributed to milk is also very small.

For the use of the drug by rectal, it is still unknown whether mesalazin will pass through the placenta and mesalazin as well as its metabolites are distributed into milk. After taking Mesalazin in healthy adults, about 20% of oral doses are eliminated in the kidneys, mainly in the form of N-acetyl-5-aminosalicylic acid and a small amount of stool.

What to do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Be cautious when using

There was a report on serious hematopathy when using Mesalazin but very rare. Need to monitor hematology, if the patient has unexplained bleeding, there are bruises, hemorrhage, anemia, fever or sore throat. Should stop the drug if there are signs of increased sensitivity or if diarrhea.

Caution with the elderly, people with liver failure, mild to moderate kidney failure, gastrointestinal ulcer. Need to monitor kidney function before and during treatment with mesalazin.

In the formula of lactose containing lactose, caution with patients with Galactose intolerance due to genetics, poor absorption of Glucose - Galactose or Lapp Lactase deficiency.

Using drugs for women during pregnancy and lactation

Pregnancy

Be cautious when used for pregnant women and only use when benefits are more than possible. There is no document about the teratogenicity of the drug, but there is a very low amount of mesalazin through the placenta.

Breastfeeding period

Be cautious during breastfeeding and use only when benefits are more than possible. There have been reports that cause diarrhea in children but only a negligible amount of drugs entered the milk. Need to monitor diarrhea in children.

The effect of the drug on the ability to drive and operate machinery

The drug can cause unwanted effects such as headache, fatigue, dizziness. Do not drive, operate machinery or work on high when encountered unwanted effects of the drug.

Medicinal interaction

Simultaneously used with oral sulfasalazin can increase the risk of toxicity to the kidneys.

There has been a notice of increasing prothrombin time in patients who are using warfarin.

Using Mesalazin in patients who use poison with the kidneys (NSAID) may increase the risk of toxicity to the kidneys.

Avoid simultaneously with medications that reduce the concentration of gastric acid, H2 antagonist, proton pump inhibitors because the effects of mesalazin may be reduced.

mesalazin increases the effects and increases the toxicity of anti -cancer substances thiopurin due to metabolic inhibition.

Mesalazin may increase the effects of chickenpox vaccine.

mesalazin can reduce the effect of cardiac glycosides.