Visartis 40 BRV treats idiopathic hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Telmisartan

Ingredient

Composition information	Content
Telmisartan	40mg

Uses

indications

Visartis 40 drugs are indicated in the following cases:

Treatment of idiopathic hypertension, can be used alone or in combination with other hypertension drugs. Angiotensin II (AT1 type) in the smooth and adrenal muscles. In the Renin-Anotensin system, Angiotensin II is made up of angiotensin I thanks to the catalyst of Angiotensin (ACE). Angiotensin II is a vascular contraction agent, stimulating synthetic adrenal skin and releasing aldosteron, stimulating the heart. Aldosteron reduces sodium excretion and increases potassium excretion in the kidneys.

Telmisartan prevents the mainly of Angiotensin II into the AT1 receptor in the blood vessel and adrenal glands, causing vessel stretching and reducing the effects of Aldosteron. The AT2 receptor is also found in many tissues, but it is unclear whether this receptor is related to the cardiovascular stability. Telmisartan has a strong affinity with AT1 receptor 3,000 times higher than the AT2 receptor. The drug does not inhibit the breaking of Bradykinin, so it does not cause persistent dry cough side effects, which can be used instead of cases where the ACE inhibitors must be stopped for them.

On the human body, the dose of 80 mg inhibits almost completely hypertension due to angiotensin II. This inhibitory effect is maintained for 24 hours and still works up to 48 hours after drinking. After taking the first dose, the hypotension effect is slowly manifested within 3 hours. Typically, the maximum reduced blood pressure is achieved after 4-8 weeks of treatment and is maintained during long -term treatment. In hypertension people, Telmisartan works to reduce both systolic and diastolic blood pressure without affecting the heart rate. The lowering effect of Telmisartan is equivalent to other anti -hypertension drugs. When stopping treatment with Telmisartan suddenly, the blood pressure will return gradually for a few days as before treatment without a sharp increase.

pharmacokinetics

Telmisartan is quickly absorbed through the digestive tract. The absolute oral bioavailability depends on the dose depends on 42% and 58% after taking the dose of 40 mg or 160 mg respectively. The peak concentration in plasma is achieved after 30 minutes to 1 hour. More than 99% of plasma proteins are mainly on albumin and al-acid glycoprotein. This cohesion does not change by the dose. Elimination of most (97%) in the form of constant biliary tract into the feces, only about 1% excreted through the urine. The sale time is about 24 hours. The drug is converted into an unnecessary acylgluconid. The drug does not cause significant accumulation when used according to the recommended dose. Plasma concentration in women is usually 2-3 times higher than men but does not see increased significance about response to blood pressure or hypotension standing in women, so there is no need to adjust the dose. There is no dynamic difference in people over 65 years old, no dose reduction for mild and medium renal failure. The fertilizer does not exclude the drug due to high protein cohesion. In people with liver failure, the blood poisoning in the blood increases and has absolute bioavailability to nearly 100%. Pharmacokinetics for children under 18 years of age have not been studied.

Before taking Visartis 40 BRV treats idiopathic hypertension (3 blisters x 10 tablets)

How to use

oral tablets, can be taken or not with food. Take the tablet with a glass of water.

Dosage

Definitely hypertension:

The normal starting dose is 40 mg, 1 time daily. Can be combined with thiazid diuretics. Date.

Reduce the risk of cardiovascular complications:

The recommended dose is 80 mg, 1 time a day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Extremely manifestations of the overdose are hypotension, slow heart rate (due to sympathetic stimulation), tachycardia; Dizziness, dizziness.

Management: Symptomatic treatment and support. In case of suspicion of intentional overdose should be transferred to psychiatric examination.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Visartis 40 you can experience unwanted effects (ADR) such as:

The drug is well tolerated, most of the unwanted effects are light and transient. Common side effects include:

Body: fatigue, headache, dizziness, limb edema, sweating. Urinary trend. Hyperbysical hyperpass. Reces of urticaria.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Visartis 40 contraindications in the following cases:

Hypersensitivity to Telmisartan or any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Need to monitor blood potassium concentration, especially in the elderly and kidney failure. Reduce the starting dose in these patients. Dehydration (decreased volume and sodium hemorrhage due to vomiting, diarrhea, prolonged diuretics, separation, salt restriction diet) because it may increase the risk of symptoms. This disorder must be adjusted before taking the drug or reducing the dose and closely monitoring at the beginning of treatment. Lap.

The effect of the drug on the ability to drive and operate machinery

Use the drug cautious for drivers or operating machinery.

Use drugs for women during pregnancy and lactation

Do not use drugs for women who are 3 months and last 3 months pregnant.

Due to the potential for harmful babies who are breastfeeding, they must decide to stop breastfeeding or stop the drug, taking into account the importance of the drug for the mother.

Drug interaction

Not enough data to evaluate safety and effectiveness when taking the drug at the same time with ACE inhibitors or beta-adrenergic inhibitors. Telmisartan can increase the effect of lowering blood pressure of these drugs.

Using at the same time with digoxin can increase the concentration of Digoxin in serum, so it is necessary to monitor the concentration of digoxin in the beginning when starting treatment, adjusting and stopping telmisartan to avoid the possibility of digoxin overdose.

Diuretics increase the hypotension effect of Telmisartan.

When used with diuretics to keep potassium as well as other drugs that cause hyperkalemia may increase the effect of hyperboly of Telmisartan.

When used at the same time as Warfarin for 10 days reduces the concentration of warfarin in the blood but does not change the INR.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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