Vitamin B1 100mg F.

Dosage form Box of 10 blisters x 10 tubes x 2ml
Specifications Thiamine, vitamin B1

Ingredient

Composition informationContent
Thiamine100mg/ml
Vitamin B1

Uses

indications

Vitamin B1 is indicated in the following cases:

  • Metabolic disorders due to genetic enzyme deficiency respond to thiamin . Pyrophosphate) has a physiological activity. Thiamin diphosphate is a carbohydrate metabolic coenzyme that reduces carboxyl of alpha - cetoacids such as pyruvat and alpha - cetoglutarat and in the use of pentose in the Hexose Monophosphate cycle.

    When Thiamin is deficient as well as Thiamin Diphosphate, the oxidation of Alpha - Cetoacids is affected, because Pyruvic acid cannot be transformed into Acetyl - CoA to continue the normal aerobic oxidation path (Kreb cycle), causing the concentration of pyruvic acid in the blood to increase and continue to convert into lactic acid. In addition, due to reduced NADH formation in the Kreb cycle stimulates anaerobic glucose resolution and produces more lactic acid. So lactic acid poisoning can occur without Thiamin.

    The deficiency of Thiamin will cause Beriberi (numbness). Mild deficiency manifests on the nervous system (dry Beriberi) such as peripheral neuritis, sensory disorders, may increase or lose sensation. The muscle tone gradually decreases and may cause a limb or paralysis. Severe deficit causes personality, depression, lack of initiative and poor memory like in Wernicke and if the late treatment causes mental rebellion Korsakoff.

    Cardiovascular symptoms due to thiamin deficiency include exertion, chest drum, tachycardia and other heart disorders. Such heart failure is called "wet beriberi"; The strong edema is as a result of a decrease in blood protein if not enough protein, or of liver disease in combination with ventricular failure.

    Dynamic pharmacokinetics

    Thiamin absorption in daily eating through the gastrointestinal tract is due to the positive transportation of Na+. However, when Thiamin concentration in the gastrointestinal tract, passive diffusion is also important, and the total amount of drug absorption when taken high doses is limited to 4 - 8 mg. Absorbing through the gastrointestinal tract decreases when patients with chronic liver disease, reducing absorption. The speed of absorption through the gastrointestinal tract will decrease when taking the medication during meals.

    Distribution into most tissues and milk. In adults, Thiamin storage is estimated at 30 mg and about 1 mg of Thiamin is completely struck every day in tissues, this is the minimum amount of daily needed. When absorbed at low levels, there are very little or no thiamin excreted through urine.

    When absorbed beyond the minimum demand, Thiamin warehouses in the saturated tissues, the amount of excretion through urine in the form of intact thiamin molecules and transformed form. When Thiamin's absorption increases further, excretion in the form of untreated thiamin will increase.

    • Before taking Vitamin B1 100mg F.

    How to use

    vitamin B1 250 mg oral.

    Dosage

    can be used up to 4 g/day, divided into several times to drink.

    Follow the instructions of the physician.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    Actively monitor for timely treatment.

    What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    When using vitamin B1 , you may experience unwanted effects (ADR).

    The harmful reactions of Thiamin are very rare and often in the style of allergies such as: sweating, shock, hypersensitivity, hypertension acute, skin rash, itching, urticaria , shortness of breath.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Vitamin B1 drug contraindicated in the following cases:

  • Sensitive to the ingredients of the drug.

    • Be cautious when using

    daily thiamin is greatly added by eating.

    When used orally, Thiamin has no remarkable caution.

    The ability to drive and operate machinery

    The drug can be used when driving operating machinery.

    Pregnancy

    can be used with low -level preparations. Do not use high doses 250 mg.

    The period of breastfeeding

    can be used with low -level preparations. Do not use high doses 250 mg.

    Interactive drug

    Vitamin B1 can increase the effects of neurotransmitter.

    Storage

    In a cool, dry place, avoid light, the temperature does not exceed 30 ° C.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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