Vitamin B1 100mg/ml Vinphaco solution treat vitamin B1 deficiency (100 tubes x 1ml)

Dosage form 100 tube box
Specifications Thiamin hydrochlorid

Ingredient

Thành phần cho 1 ống

Composition information	Content
Thiamin hydrochlorid	100mg

Uses

indicated

Vitamin B1 100mg/ml injection solution indicated for treatment of diseases due to vitamin B1 deficiency when can not be used orally.

Pharmacology

MX ATC: A11D A01

Thiamin combined with adenosin triphosphate (ATP) in the liver, kidneys and leukocytes forms thiamin diphosphate (thiamin pyrophosphate) with physiological activity,.

Thiamin pyrophosphate is the carbohydrate metabolic carbohydrate that reduces the carboxyl of alpha - cetoncids such as pyruvate and alpha - cetoglutarat and in using pentose in the hexose monophat cycle.

The daily amount of thiamin takes 0.9 to 1.5 mg for men and 0.8 to 1.1 mg for healthy women.

Thiamin needs are directly related to carbohydrate and metabolic speed. This has practical significance in nourishing patients with intravenous and intravenous sugars in patients with calorie energy taken mainly from Dexrose (Glucose).

During the shortage of Thiamin, the oxidation of the affected alpha -cetoacids, because Pyruvic acid cannot be transformed into Acetyl CoA to continue the oxidation pathway when normal (Kreb cycle), causing pyruvic acid levels in the blood and continue to convert into lactic acid.

In addition, due to the reduction in the formation of NADH during the Kreb cycle stimulates anaerobic glucose resolution and produces more lactic acid. Therefore, lactic acid poisoning can occur without Thiamin.

The deficiency of Thiamin will cause Beriberi (numbness). Mild deficiency manifests on the nervous system (dry Beriberi) such as peripheral neuritis, sensory disorders, may increase or lose sensation. The muscle tone gradually decreases and can cause a limb or paralysis.

Severe deficit causes personality, depression, lack of innovation and poor memory like in Wernicke and if the late treatment causes mental rebellion Korsakoff.

Cardiovascular symptoms due to thiamin deficiency include exertion, chest drumming, tachycardia and other disorders on the heart are manifested by electrocardiogram changes (mainly low R waves, reverse t waves and extension of segment 2 - T) and with high heart failure.

Such heart failure is called "wet beriberi"; The strong edema is as a result of a decrease in blood protein if not enough protein, or of liver disease in combination with ventricular failure.

pharmacokinetics

Thiamin absorption in daily eating through the gastrointestinal tract is due to the positive transportation of Na+.

When the thiamin concentration in the digestive tract is also important. However, high -dose absorption is limited.

After intramuscular injection, Thiamin is also quickly absorbed, allocated into most tissues and milk.

In adults, Thiamin stores are estimated at 30 mg and about 1 mg of Thiamin is completely struck every day in tissues, and this is the minimum amount of daily need.

When absorbed at this low level, there are very little or no thiamin excreted through the urine.

When absorbing exceeds the minimum demand, Thiamin warehouses in saturated tissues. The excess amount will then be eliminated through the urine in the form of intact thiamin molecules.

When the thiamin absorption increases further, excretion in the form of unprocessed thiamin will increase.

Before taking Vitamin B1 100mg/ml Vinphaco solution treat vitamin B1 deficiency (100 tubes x 1ml)

How to use

Vitamin B1 injection solution 100mg/ml for intramuscularly.

Dosage

Dosage recommended: Adults, 1 - 2 tubes 100 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects (ADR) when using Vitamin B1 100mg/ml injection solution that you may encounter.

The harmful reactions of Thiamin are very rare and often allergic. Hypersensitivity reactions occur mainly when injecting.

Hypersensitivity shock only occurs when injecting, and only thiamin injections; If used in combination with other B vitamins, the reaction does not occur. Normally, because Thiamin enhances the effects of acetylcholin, some skin reactions can be considered as an allergic reaction.

Rare ADR

Systemic body: Sweating, hypersensitivity Most for timely management.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vitamin B1 injection solution 100mg/ml contraindicated in the following cases:

Hypersensitivity to Thiamin or any ingredients of the preparation.

Be cautious when using

Hypersensitivity reactions can occur when the intramuscular injection repeats many times.

Women during pregnancy and lactation

Pregnant women:

No teratical studies in animals.

Clinically, so far has no teratogenic effect when used at a dose of 100 mg.

However, clinical studies are not complete. Therefore, as a preventive measure, it is better not to use this drug during pregnancy.

breastfeeding women:

Diets needed for pregnant women are 1.5 mg of thiamin. Thiamin is actively transported to the fetus. Like other B vitamins, Thiamin concentration in fetus and babies is higher than the mother.

There is no complete research on the use of high doses of Thiamin when breastfeeding. Therefore, do not breastfeed when taking this medication.

The ability to drive and operate machinery

The drug does not affect the operator, is driving the train, the person working on high and other cases.

Interactive drug

Thiamin can increase the effect of neurotransmitter.

Medication interactions can affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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