Vitamin B1 250mg Domesco treatment is treated by vitamin B1 deficiency (20 blisters x 10 tablets)

Dosage form Hard capsules (brown-xanh)
Specifications Box of 20 blisters x 10 tablets
Ingredient Thiamin mononitrate
Indication Beriberi's disease, fatigue, neuritis, neurasthenia, migraine, rheumatism

Ingredient

Composition information	Content
Thiamin mononitrate	250mg

Uses

Indication

Vitamin B1 250mg is indicated in the following cases:

Treatment of diseases due to vitamin B1 deficiency.

Pharmacokic

Thiamin is a water -soluble vitamin, belonging to group b.

Thiamin combined with Adenosin Triphosphate (ATP) in the liver, kidneys and leukocytes to form Thiamin Diphosphate (Thiamin Pyrophosphate) has a physiological activity. Thiamin diphosphate is a carbohydrate metabolic coenzyme that is responsible for reducing the carboxyl of alpha-cetoacids such as pyruvat and alpha-cetoglutarat and in the use of pentose in the Hexose Monophosphate cycle.

Thiamin is often used in the form of hydrochloride or nitrate salt, in addition to using decamsylate, disult, monophosphate or pyrophosphate (cocarboxylase). Other types of combinations considered as vitamin B1 can also be used instead of Thiamin such as Benfotiamin, Cycotiamin, Octotiamin ...

The daily amount of thiamin takes 0.9 - 1.5 mg for men and 0.6 - 1.1 mg for healthy women. Thiamin demand is directly related to carbohydrate and metabolic speed. This has practical significance in nourishing patients with intravenous tract and in patients with calorie energy taken mainly from Dexrose (Glucose).

During Thiamin deficiency as well as Thiamin Diphosphate, the oxidation of Alpha-Cetoacids is affected, because Pyruvic acid cannot be transformed into acetyl-coa to continue on the regular aerobic oxidation path (KREB cycle), causing pyruvic acid levels in the blood to increase and continue to change into lactic acid. In addition, due to reduced NADH formation in the Kreb cycle stimulates anaerobic glucose resolution and produces more lactic acid. So lactic acid poisoning can occur without Thiamin.

The deficiency of Thiamin will cause Beriberi (numbness). Mild deficiency manifests on the nervous system (dry Beriberi) such as peripheral neuritis, sensory disorders, may increase or lose sensation. The muscle tone gradually decreases and may cause a limb or paralysis. Severe deficit causes personality, depression, lack of initiative and poor memory like in Wernicke and if the late treatment causes mental rebellion Korsakoff.

Cardiovascular symptoms due to thiamin deficiency include exertion, chest drumming, tachycardia and other disorders on the heart are manifested by electrocardiogram changes (mainly low R waves, reverse T waves and stretching q - t) and heart failure with high cardiac weight. Such heart failure is called "wet beriberi"; The strong edema is as a result of a decrease in blood protein if not enough protein, or of liver disease in combination with ventricular failure.

Thiamin shortage can occur due to many reasons as follows:

Although available in food, due to the less durable with temperature and light, the improper storage and processing process will quickly reduce this vitamin content.

Due to the increasing demand, but not enough: puberty, pregnancy, lactation, serious illness, alcoholism, nurturing venous sugar.

Due to reduced absorption: prolonged diarrhea, elderly.

Due to the loss of this vitamin when the peritoneal, hemolysis.

Dynamic pharmacokinetics

Thiamin absorption in daily eating through the gastrointestinal tract is due to the positive transportation of Na. However, when Thiamin concentration in the gastrointestinal tract, passive diffusion is also important and the total amount of drug absorption when taken high doses is limited to 4 - 8 mg. Absorbing through the gastrointestinal tract decreases when patients with chronic liver disease, reducing absorption. The speed of absorption through the gastrointestinal tract will decrease when taking the medication during meals.

Distribution into most tissues and milk.

In adults, Thiamin storage is estimated at 30 mg and about 1 mg of Thiamin is completely struck every day in tissues, this is the minimum amount of daily needed. When absorbed at this low level, there are very little or no thiamin excreted through the urine.

When absorbed beyond the minimum demand, Thiamin warehouses in the saturated tissues, the amount of excretion through urine in the form of intact thiamin molecules and transformed form. When Thiamin's absorption increases further, excretion in the form of untreated thiamin will increase.

Before taking Vitamin B1 250mg Domesco treatment is treated by vitamin B1 deficiency (20 blisters x 10 tablets)

How to use

Take orally, use food to increase absorption.

Dosage

Vitamin B1 250 mg is a form of drug that is not allowed to divide the dose smaller than the unit of 250 mg. Therefore, in the case of patients using other doses at a dose of 250 mg, a doctor or pharmacist should be consulted for appropriate instructions.

In the case of serious lack of Thiamin:

Take 1 capsule/time/day.

Metabolic disorders due to genetic enzyme deficiency respond to thiamin:

Maximum dose of 4 g/day, divided into several times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose.

Side Effects

When using vitamin B1 250mg, you may experience unwanted effects (ADR).

Rare:

Systemic: Sweating, hypersensitivity.

circulating: acute hypertension. skin: skin, itching, urticaria.

Respiratory: Difficulty breathing.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Vitamin B1 250mg is contraindicated in cases of hypersensitivity to thiamin and other ingredients of the drug.

Be cautious when using

There is no careful reporting data of the drug.

The ability to drive and operate machinery

There has been no report on the effects of drugs when used in subjects that need alertness and high concentration such as driving, operating machinery.

Pregnancy

There is no risk known. The diet needed for pregnant women is 1.5 mg thiamin. Thiamin is actively transported to the fetus. Like other B vitamins, Thiamin concentration in fetuses and babies is higher in the mother. One study found that fetuses with alcoholic syndrome (due to alcoholic mother) developed very slowly in the uterus was due to lack of alcohol.

The period of breastfeeding

Mother uses Thiamin to continue breastfeeding. Thiamin daily diet during breastfeeding is 1.6 mg. If the diet of nursing mothers is fully provided, there is no need to add thiamin. Just supplement Thiamin if the daily diet is not enough.

Interactive drug

Thiamin can increase the effect of neurotransmitter.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.